초록 ▼

○ 피부질환 개선 기능성 소재 탐색·선발 및 선발 소재의 사료화를 위한 영양성분 및 유효성분 함량 특성 평가
○ 선발된 기능성 소재(보라지유, 발효귀리, 동애등에)의 반려견 건강증진 효과 구명
○ 알레르겐 선정: 흡입성/접촉성 알레르겐 5종, 음식물 알레르겐 5종 선정
○ 신속진단키트 제조기법 확립: 피부질환 신속진단 키트제조조건 확립
○ 반려견 피부질환 원인 신속진단 키트 시제품 제작 및 특허출원
○ 집먼지 진드기 알러젠 적용 아토피 마우스 모델에 Syn-bio제제의 효능을 평가하여 실질적으로 반려동물

○ 피부질환 개선 기능성 소재 탐색·선발 및 선발 소재의 사료화를 위한 영양성분 및 유효성분 함량 특성 평가
○ 선발된 기능성 소재(보라지유, 발효귀리, 동애등에)의 반려견 건강증진 효과 구명
○ 알레르겐 선정: 흡입성/접촉성 알레르겐 5종, 음식물 알레르겐 5종 선정
○ 신속진단키트 제조기법 확립: 피부질환 신속진단 키트제조조건 확립
○ 반려견 피부질환 원인 신속진단 키트 시제품 제작 및 특허출원
○ 집먼지 진드기 알러젠 적용 아토피 마우스 모델에 Syn-bio제제의 효능을 평가하여 실질적으로 반려동물 임상에 적용 가능성 확인
○ Syn-bio제제를 이용하여 실질적으로 시판할 수 있는 아토피 개선 기능성 스프레이 제제 개발 후 동물병원 내원 환자를 대상 개선 양상 확인

(출처 : 요약서 3p)

Abstract ▼

□ Purpose&Contents
○ Development of functional feed prototype for skin disease prevention of companion animals
- Investigation of nutritional characteristics of functional ingredients that improve the skin disease
- Development of functional feed manufacturing technology and simple manufact

□ Purpose&Contents
○ Development of functional feed prototype for skin disease prevention of companion animals
- Investigation of nutritional characteristics of functional ingredients that improve the skin disease
- Development of functional feed manufacturing technology and simple manufacturing method for skin disease prevention
- Develop functional feed prototypes and provide a cooperative team to verify its efficacy
○ Development of a point-of-care test for companion animals' allergy specialized in the domestic environment
- Investigation and selection of allergen candidates for the manufacture of a point-of-care test for companion animals' allergy
- Established the optimal combination of allergens for the manufacture of a point-of-care test for companion animals' allergy
- Optimization of manufacturing conditions for a point-of-care test for companion animals' allergy
- Prototype production of a point-of-care test for companion animals' allergy
○ The purpose of this study is to confirm and develop skin supplies for prevention/ treatment of atopic dermatitis.
- The efficacy of Synbio component was confirmed on atopic dermatitis mouse model and the dogs, which were presented to animal hospitals with atopic dermatitis.

□ Results
○ Screening and selection of functional materials to improve skin diseases and evaluation of nutrient- and active ingredientcontent in selected materials
○ Study on the effect of functional feed using selected materials to improve health of companion dogs
- Verification of the effect of borage oil to improve skin damage in dogs
- Verification of reduction effect of black solider fly larva on serum cholesterol in dogs
- Verification of effect of fermented oats and black solider fly larva on immunity improvement in dogs
○ Allergen selection: 5 inhalant/contact allergens, 5 food allergens selected
-Allergen partial purification and standardization
○ Establishment of a point-of-care test kit manufacturing method: Establishment of manufacturing conditions forpoint-of-care test kits
- Kit structure and device configuration,
- Establishment of coating technology, conjugate pad, and sample pad manufacturing conditions,
- Establishing the optimal combination of allergens
- Establishment of allergen and device QC test methods
○ Prototype production of a point-of-care test kit and securing intellectual property rights: Prototype production and patent application of a point-of-care test kit for the cause of skin disease in dogs
○ The efficacy of Syn-bio component was confirmed with atopic dermatitis mouse model using house dust mite allergen.
○ The functional spray with Syn-bio component were tested to the dogs, which were presented to animal hospitals with atopic dermatitis, and we confirmed the improvement of atopic dermatitis in the dogs.

□ Expected Contribution
○ Use as basic academic data by presenting the effects of natural materials for preventing and therapy skin diseases
○ Secure various patent through discovery and development of new functional natural materials
○ Reduction of the pain caused by skin diseases of the companion animal and the burden of medical expenses for pet owners
○ Contributing to the development of localization technology for high quality functional feed for companion animal
○ Promote commercialization of the point-of-care test for dog allergens developed in this project through clinical trials and quarantine approval procedures.
○ The expectation of import substitution effect of dog allergen diagnostic reagents, which are currently mainly made by imported products.
○ Contributing to the development of point-of-care test technology for companion animal diseases
○ Contributing to the improvement of companion animal welfare by helping to treat companion animal diseases
○ Industrial property right will transfer to the committed research institution ‘Boran animal health’ and the products will be commercialized.

(출처 : SUMMARY 6p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국 문 요 약 문 ... 5
• Summary ... 6
• 목차 ... 9
• 제 1 장 연구 개발 과제의 개요 ... 10
• 제1절 연구 개발 목적 ... 10
• 제2절 연구 개발의 필요성 ... 10
• 제3절 연구 개발 범위 ... 11
• 제 2 장 연구 수행 내용 및 결과 ... 12
• 제 3 장 목표달성도 및 관련분야 기여도 ... 78
• 제1절 목표대비 달성도 ... 78
• 제2절 정량적 성과(논문게재, 특허출원, 기타)를 기술 ... 80
• 제 4 장 연구 결과의 활용 계획 ... 81
• 제 5 장 연구 개발 결과의 보안 등급 ... 82
• 제 6 장 연구시설·장비종합정보시스템에 등록한 연구시설·장비 현황 ... 82
• 제 7 장 연구개발과제의 대표적 연구실적 ... 82
• 제 8 장 기타사항 ... 83
• 제 9 장 참고문헌 ... 84
• 끝페이지 ... 87