초록

Abstract ▼

ㅇ 연구개요
In this study, we developed dual targeted nanoparticle as an anticancer drug
carrier. We attached folate ligand to the nanoparticle to enhance tumor cell
targeting ability of the nanoparticles and mitochondria targeting agent was
attached to anticancer drug (Docetaxel) that is kno

ㅇ 연구개요
In this study, we developed dual targeted nanoparticle as an anticancer drug
carrier. We attached folate ligand to the nanoparticle to enhance tumor cell
targeting ability of the nanoparticles and mitochondria targeting agent was
attached to anticancer drug (Docetaxel) that is know to initiate apoptotic cell
death by localizing in mitochondria.
Also, we developed active targeted gold nanoparticle as anticancer drug carrier
system. Here, we used hyaluronic acid as coating material and targeting ligand
due to its biocompatibility and selectivity to CD44 receptor-overexpressing on
cancer cells.

ㅇ 연구 목표대비 연구결과
The purpose of this study was to develop advanced therapeutic agent for
cancer treatment using active targeted nanoparticles. First, we synthesized
mitochondria-targeting drug (TPP-DTX) and then loaded to the folate-targeted
albumin nanoparticles. The hydrodynamic size of the conjugate-loaded NPs was
around 130 nm and the NPs were applied for cell and animal studies. The
results revealed that the TPP-DTX-loaded albumin nanoparticles have ability to
induce apoptotic cell death and strongly suppress the tumor growth in
tumor-bearing mice. Further, we purposed to develop active-targeted gold
nanoparticles as anticancer drugs (DTX and cisplatin) carries. We attached
hyaluronic acid to the surface of gold nanoparticle using cleavable linkage and
PEG. Then, anticancer drug DTX and cisplatin was loaded to the nanoparticle.
The hydrodynamic diameter and zeta potential of the nanoparticles were
75-140 nm and negative, respectively. The cell and animal study results
conformed that the nanoparticle have the ability to treat the cancer cells and
control the tumor growth in the presence of laser irradiation.

ㅇ 연구개발결과의 중요성
Through doing this research, we found that use of dual targeted therapeutic
agent can reduce the dosage of anticancer agent and could be more potent
against drug-resistant tumor.
Gold nanoparticles have been known to be a promising agent for drug delivery
and diagnosis. Through this study, we tried to demonstrate that enhancement of
biocompatibility and targeting ability of gold nanoaprticle can help to be more
potent carrier system. Additionally, use of laser with drug-loaded gold
nanoparticle enables to get synergistic antitumor effect owing to hyperthermia
effect of gold nanoparticles.


(source: SUMMARY 2p)

목차 Contents

• COVER ... 1
• 연구결과 요약문 ... 2
• 1. 연구개발과제의 개요 ... 3
• 2. 연구수행내용 및 연구결과 ... 4
• 2.1. Results ... 4
• 2.2. Results ... 9
• 3. 연구개발결과의 중요성 ... 13
• 4. 참고문헌 ... 16
• 5. 연구성과 ... 17
• End of Page ... 18