초록 ▼

□ 연구개발 목표 및 내용
○ 최종 목표
스트레스 관련질환에 한의치료의 장-뇌축 기전규명을 위한 국제공동연구기획

○ 전체 내용
스트레스 관련질환에 대한 한의치료의 장-뇌축 기전규명을 위한 국제공동연구 기획 및 임상/비임상연구 수행

○ 1단계
□ 목표
국제공동연구 최종 기획안 도출 및 스트레스 관련질환의 임상/비임상연구 수행

□ 내용
국제공동연구기획 및 한의치료를 위한 변증연구/동물모델 기전연구 수행

□ 연구개발성과
• MGH와 공동연구를 통한 장

□ 연구개발 목표 및 내용
○ 최종 목표
스트레스 관련질환에 한의치료의 장-뇌축 기전규명을 위한 국제공동연구기획

○ 전체 내용
스트레스 관련질환에 대한 한의치료의 장-뇌축 기전규명을 위한 국제공동연구 기획 및 임상/비임상연구 수행

○ 1단계
□ 목표
국제공동연구 최종 기획안 도출 및 스트레스 관련질환의 임상/비임상연구 수행

□ 내용
국제공동연구기획 및 한의치료를 위한 변증연구/동물모델 기전연구 수행

□ 연구개발성과
• MGH와 공동연구를 통한 장-뇌축 조절기전 규명 연구 진행
• NIH와의 공동연구툴 통한 우울증 동물 모델에서의 한약제제의 치료효능율 규명하는 논문 1편 및 특허출원
• 국제공동연구 기획을 위한 장-뇌축 스트레스 관련 질환의 임상/비임상 연구 수행

□ 연구개발성과 활용계획 및 기대 효과
MGH, NIH와의 공동연구 결과와 연구원에서 수행한 장-뇌축 스트레스 관련 질환 임상/비임상 연구 결과 향후 국제공동연구 및 장-뇌축 스트레스 관련 질환 한의치료 연구에 이용

(출처 : 요약문 5p)

Abstract ▼

□ International joint research planning and implementation to identify the mechanism of intestinal-brain axis regulation of oriental medicine treatment
○ Through joint research with Professor Braden Kuo of the Center for Neurological Diseases at Harvard Medical School and Massachusetts General Ho

□ International joint research planning and implementation to identify the mechanism of intestinal-brain axis regulation of oriental medicine treatment
○ Through joint research with Professor Braden Kuo of the Center for Neurological Diseases at Harvard Medical School and Massachusetts General Hospital, we analyzed gut microbiome data from the registry of digestive diseases caused by stress.
○ Prof. Braden Kuo and Professor Satish Rao of Augusta University are planning a new joint study to apply the ‘gut-brain axis’ neuromodulation therapy to fecal incontinence patients.
○ The discussion for the international joint research plan using complementary and alternative medicine to expand the treatment protocol for neurodigestive diseases at the Neuromedical Disease Center in MGH is ongoing.
○ Discussion to plan a new joint research project on intestinal-brain axis disease or vagus nerve stimulation using ear needles through videoconference with MGH Vitaly Napadow.

□ Through joint research with National Institutes of Healthy (NIH), Identified the therapeutic efficacy of herbal medicines in an animal model of depression.
○ Through technical exchanges and joint research with the NIH research team, an animal model of inflammatory depression is implemented, and among the candidates for herbal medicines effective for the improvement of inflammatory depression, MCA, an effective substance of broiler chicken (CV), will be utilized as a new antidepressant to control inflammatory depression. A paper suggesting that it can be published in an SCI-level journal.
○ Based on the results of joint research with the NIH research team, we applied for a patent for a composition development technology for improving fatigue of broiler extract.

□ Discussion on international joint research planning using fusion therapy of median nerve stimulation and brain stimulation with Professor Stephen's team at the University of Nottingham.
○ Discussion on the possibility of joint research through technical exchange with Professor Stephen Jackson's team at the University of Nottingham on the treatment efficacy of patients with movement disorders using non-invasive brain stimulation technology using TMS and median nerve stimulation technology.

□ Conducting clinical research on human subjects to evaluate the efficacy of oriental medicine treatment for stress-related diseases for international joint research planning and to secure new herbal medicine resources
○ Identification of brain scientific treatment mechanism for diagnosis and fusion treatment of Korean medicine for post-traumatic stress disorder disease.
○ Identification of the brain scientific treatment mechanism of herbal medicines for irritable bowel disease.

□ Mechanism study of stress-related diseases through animal model construction
○ Post-traumatic stress disorder (PTSD) animal model establishment and improvement of fear removal of acupoint stimulation
○ Tissue analysis and mechanism identification of irritable bowel disease animal model

□ Derivation of cell-customized herbal medicine candidates for the treatment of stress-related diseases
○ Derivation of candidate substances for cell-specific inflammatory response oriental medicine.

(source : Summary 6p)