초록

Ⅳ. 연구개발결과
- 천식모델에서 eosinophil에 PPARγ 결핍 시 Th1과 ILC2와 같은 염증성 세포의 증가로 인한 증상의 심화와 미토콘드리아의 감소를 확인.
- 천식을 유도한 폐 eosinophil에서 추출한 분해된 RNA로부터 cDNA library를 합성하는 방법을 확립.

(출처 : 요약문 4p)

Abstract ▼

In asthma model, PPARγ deficiency in eosinophils resulted in increase of inflammatory Th1 and ILC2 aggravating symptoms of asthma. In addition, the mitochondrial biogenesis was impaired in PPARγ-deficient eosinophils. It shows that PPARγ is one of the regulator of anti-inflammatory functions of eosi

In asthma model, PPARγ deficiency in eosinophils resulted in increase of inflammatory Th1 and ILC2 aggravating symptoms of asthma. In addition, the mitochondrial biogenesis was impaired in PPARγ-deficient eosinophils. It shows that PPARγ is one of the regulator of anti-inflammatory functions of eosinophils. Also, the technique for cDNA library synthesis from highly degraded eosinophil RNA is established to compare the eosinophil transcriptome in various conditions.

(source : Summary 5p)