초록 ▼

Ⅳ. 연구개발결과 – Results
pBNST TRH-MPA projection activation drives same-sex mounting in males and decreases aggression.
This same-sex mounting behaviour cannot be triggered by odour alone, persists in the presence of a distractor female, lacks valence and does not induce USVs.
pBNST TRH-MPA pr

Ⅳ. 연구개발결과 – Results
pBNST TRH-MPA projection activation drives same-sex mounting in males and decreases aggression.
This same-sex mounting behaviour cannot be triggered by odour alone, persists in the presence of a distractor female, lacks valence and does not induce USVs.
pBNST TRH-MPA projection inhibition may be capable of inducing aggression in male mice.

(출처 : 요약문 4p)

Abstract ▼

Pheromones are a type of hormone signal that can be used to coordinate behaviour between animals. We identfiied pBNST TRH neural connections to the MPA as being capable of driving same-sex mounting in male mice without altering mounting towards females. Using optogenetics, FISH, and electrophysiolog

Pheromones are a type of hormone signal that can be used to coordinate behaviour between animals. We identfiied pBNST TRH neural connections to the MPA as being capable of driving same-sex mounting in male mice without altering mounting towards females. Using optogenetics, FISH, and electrophysiology, we show that this same-sex behaviour is not the result of mice mistakenly identifying conspecifics as female mice. Instead, this behaviour appears to be either independent of odour signaliling, or requires odour signalling coupled with other sensory cues to trigger same-sex mounting. Consistent with this, we failed to see any increases in fos expression in pBNST TRH neurons after exposure to male or female urine. Finally we show that inhibition of pBNST TRH terminals in the MPA can increase aggression towards males, in male mice. These results taken together suggest that pheromone signalling alone is not sufficient to drive-sex dependent behaviour and most likely must be integrated with other types of sensory infromation to drive appropriate behavioural output.

(source : Summary 6p)

목차 Contents

• COVER ... 1
• 제 출 문 ... 2
• 보고서 초록 ... 3
• 요 약 문 ... 4
• SUMMARY ... 6
• CONTENTS ... 7
• 목차 ... 8
• 제 1 장 연구개발과제의 개요 ... 9
• 제 2 장 국내외 기술개발 현황 ... 10
• 제 3 장 연구개발수행 내용 및 결과 ... 13
• Figure 1) Light driven excitation of pBNST TRH neurons ... 15
• Figure 2) Photostimulation of pBNST TRH neurons in vivo ... 16
• Figure 3) CRACM from pBNST TRH neurons to MPA neurons ... 18
• Figure 4) In situ hybridisation of pBNST TRH neurons after exposure to male and female urine ... 19
• Figure 5) Light driven inhibition of pBNST TRH neurons ... 21
• Figure 6) Photoinhibition of pBNST TRH neurons in vivo ... 22
• 제 4 장 목표달성도 및 관련분야에의 기여도 ... 23
• 제 5 장 연구개발결과의 활용계획 ... 24
• 제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 25
• 제 7 장 참고문헌 ... 26
• End of Page ... 28