초록 ▼

Ⅳ. 연구개발결과
- 섬유아세포 (NIH3T3 fibroblast)와 각질세포 (keratinocyte)을 이용한 공배양을 통해 인공피부조직 제작하고 이를 조직학적 분석을 통해 다층구조가 형성되었음을 확인함.
- 제작된 인공피부조직을 활용하여 해당 과제를 통해 개발하고 있는 공조시스템의 핵심 부품인 플라즈마 모듈과 촉매 모듈을 통해 배출된 공기가 인체에 미치는 영향을 확인함.
- 소재 별로 원 내에서 구현 가능한 독성평가 방법을 선정하고 이 결과를 공인된 시험평가 기관 결과와 비교해 그 신뢰성을 검증하였음.
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Ⅳ. 연구개발결과
- 섬유아세포 (NIH3T3 fibroblast)와 각질세포 (keratinocyte)을 이용한 공배양을 통해 인공피부조직 제작하고 이를 조직학적 분석을 통해 다층구조가 형성되었음을 확인함.
- 제작된 인공피부조직을 활용하여 해당 과제를 통해 개발하고 있는 공조시스템의 핵심 부품인 플라즈마 모듈과 촉매 모듈을 통해 배출된 공기가 인체에 미치는 영향을 확인함.
- 소재 별로 원 내에서 구현 가능한 독성평가 방법을 선정하고 이 결과를 공인된 시험평가 기관 결과와 비교해 그 신뢰성을 검증하였음.

(출처 : 요약문 4p)

Abstract ▼

For the safety of chemical substances or the development of new drugs, preclinical studies before clinical trials are essential. However, preclinical trials are a significant obstacle to new drug development because they require a lot of time and money. Also, the results of preclinical trials and cl

For the safety of chemical substances or the development of new drugs, preclinical studies before clinical trials are essential. However, preclinical trials are a significant obstacle to new drug development because they require a lot of time and money. Also, the results of preclinical trials and clinical trials are not always consistent. And the movement to ban animal testing is spreading around the world. Therefore, a means to replace preclinical test evaluation using animals is necessary. In this research project, we tried to develop artificial skin tissue that can be used as a substitute for preclinical test evaluation. Artificial skin could mimic actual human skin tissue by using human skin cells. Cell culture conditions for producing it were established, and through this, artificial skin tissue was made through co-culture of epidermal cells and keratinocytes. And, through this, the effect of ozone generated from the plasma generator and the degree of damage to the artificial skin tissue exposed to the air in which ozone is removed from the catalytic material was confirmed. Therefore, it is expected to be able to directly evaluate the effects of actual chemicals and environments on human skin. Additionally, a biocompatibility evaluation method for biomaterials being developed within the research institute was established. When developing a new biomaterial, it must go through biocompatibility evaluation, but receiving the result through an external institution requires a lot of time and money. Therefore, to solve this problem, the same protocol was introduced within the research institute and an infrastructure capable of performing biocompatibility evaluation was established. Through this, it is expected that the research institute will be able to develop biomaterials more effectively.

(source : Summary 5p)