$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study 원문보기

Genomics & informatics, v.9 no.2, 2011년, pp.59 - 63  

Lee, Hae-In (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ,  Kim, Jae-Jung (Asan Institute for Life Sciences, University of Ulsan College of Medicine) ,  Park, Tae-Sung (Department of Statistics, College of Natural Science, Seoul National University) ,  Kim, Kyung-A (Department of Statistics, Sookmyung Women's University) ,  Lee, Jong-Eun (DNA Link) ,  Cho, Yoon-Shin (Center for Genome Science, National Institute of Health) ,  Lee, Jong-Young (Center for Genome Science, National Institute of Health) ,  Han, Bok-Ghee (Center for Genome Science, National Institute of Health) ,  Lee, Jong-Keuk (Asan Institute for Life Sciences, University of Ulsan College of Medicine)

Abstract AI-Helper 아이콘AI-Helper

Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (...

주제어

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

문제 정의

  • In summary, we sought to identify additional genetic variants influencing BMI by analyzing specific subsets of previously reported GWAS data and replication study. In this study, we confirmed the association of MC4R with BMI. However, we failed to identify new genetic variants associated with BMI in Koreans.
본문요약 정보가 도움이 되었나요?

참고문헌 (17)

  1. Atwood, L.D., Heard-Costa, N.L., Cupples, L.A., Jaquish, C.E., Wilson, P.W., and D'Agostino, R.B. (2002). Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am. J. Hum. Genet. 71, 1044-1050. 

  2. Bogardus, C. (2009). Missing heritability and GWAS utility. Obesity 17, 209-210. 

  3. Cho, Y.S., Go, M.J., Kim, Y.J., Heo, J.Y., Oh, J.H., Ban, H.J., Yoon, D., Lee, M.H., Kim, D.J., Park, M., Cha, S.H., Kim, J.W., Han, B.G., Min, H., Ahn, Y., Park, M.S., Han, H.R., Jang, H.Y., Cho, E.Y., Lee, J.E., Cho, N.H., Shin, C., Park, T., Park, J.W., Lee, J.K., Cardon, L., Clarke, G., McCarthy, M.I., Lee, J.Y., Lee, J.K., Oh, B., and Kim, H.L. (2009). A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41, 527-534. 

  4. Haslam, D.W., and James, W.P. (2005). Obesity. Lancet 366, 1197-1209. 

  5. Hinney, A., Bettecken, T., Tarnow, P., Brumm, H., Reichwald, K., Lichtner, P., Scherag, A., Nguyen, T.T., Schlumberger, P., Rief, W., Vollmert, C., Illig, T., Wichmann, H.E., Schafer, H., Platzer, M., Biebermann, H., Meitinger, T., and Hebebrand, J. (2006). Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J. Clin. Endocrinol. Metab. 91, 1761-1769. 

  6. Hofker, M., and Wijmenga, C. (2009). A supersized list of obesity genes. Nat. Genet. 41, 139-140. 

  7. Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P., and Lee, F. (1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141. 

  8. Janssen, I., and Mark, A.E. (2007). Elevated body mass index and mortality risk in the elderly. Obes. Rev. 8, 41-59. 

  9. Kublaoui, B.M., and Zinn, A.R. (2006). MC4R Mutationsweight before screening!. J. Clin. Endocrinol. Metab. 91, 1671-1672. 

  10. Maes, H.H., Neale, M.C., and Eaves, L.J. (1997). Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 27, 325-351. 

  11. Manolio, T.A., Collins, F.S., Cox, N.J., Goldstein, D.B., Hindorff, L.A., Hunter, D.J. McCarthy, M.I., Ramos, E.M., Cardon, L.R., Chakravarti, A., Cho, J.H., Guttmacher, A.E., Kong, A., Kruglyak, L., Mardis, E., Rotimi, C.N., Slatkin, M., Valle, D., Whittemore, A.S., Boehnke, M., Clark, A.G., Eichler, E.E., Gibson, G., Haines, J.L., Mackay, T.F., McCarroll, S.A., and Visscher, P.M. (2009). Finding the missing heritability of complex diseases. Nature 461, 747-753. 

  12. Marti, A., Corbalan, M.S., Forga, L., Martinez, J.A., Hinney, A., and Hebebrand, J. (2003). A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population. Int. J. Obes. Relat. Metab. Disord. 27, 385-388. 

  13. Meyre, D., Delplanque, J., Chevre, J.C., Lecoeur, C., Lobbens, S., Gallina, S. Durand, E., Vatin, V., Degraeve, F., Proenca, C., Gaget, S., Korner, A., Kovacs, P., Kiess, W., Tichet, J., Marre, M., Hartikainen, A.L., Horber, F., Potoczna, N., Hercberg, S., Levy-Marchal, C., Pattou, F., Heude, B., Tauber, M., McCarthy, M.I., Blakemore, A.I., Montpetit, A., Polychronakos, C., Weill, J., Coin, L.J., Asher, J., Elliott, P., Jarvelin, M.R., Visvikis-Siest, S., Balkau, B., Sladek, R., Balding, D., Walley, A., Dina, C., and Froguel, P. (2009). Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157-159. 

  14. Romero-Corral, A., Somers, V.K., Sierra-Johnson, J., Thomas, R.J., Collazo-Clavell, M.L., Korinek, J., Allison, T.G., Batsis, J.A., Sert-Kuniyoshi, F.H., and Lopez-Jimenez, F. (2008). Accuracy of body mass index in diagnosing obesity in the adult general population. Int. J. Obes (Lond). 32, 959-966. 

  15. Thorleifsson, G., Walters, G.B., Gudbjartsson, D.F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., Jonsdottir, T., Olafsdottir, E.J., Olafsdottir, G.H., Jonsson, T., Jonsson, F., Borch-Johnsen, K., Hansen, T., Andersen, G., Jorgensen, T., Lauritzen, T., Aben, K.K., Verbeek, A.L., Roeleveld, N., Kampman, E., Yanek, L.R., Becker, L.C., Tryggvadottir, L., Rafnar, T., Becker, D.M., Gulcher, J., Kiemeney, L.A., Pedersen, O., Kong, A., Thorsteinsdottir, U., and Stefansson, K. (2009). Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18-24. 

  16. WHO Expert Consultation. (2004). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363, 157-163. 

  17. Willer, C.J., Speliotes, E.K., Loos, R.J., Li, S., Lindgren, C.M., Heid, I.M., Berndt, S.I., Elliott, A.L., Jackson, A.U., Lamina, C., Lettre, G., Lim, N., Lyon, H.N., McCarroll, S.A., Papadakis, K., Qi, L., Randall, J.C., Roccasecca, R.M., Sanna, S., Scheet, P., Weedon, M.N., Wheeler, E., Zhao, J.H., Jacobs, L.C., Prokopenko, I., Soranzo, N., Tanaka, T., Timpson, N.J., Almgren, P., Bennett, A., Bergman, R.N., Bingham, S.A., Bonnycastle, L.L., Brown, M., Burtt, N.P., Chines, P., Coin, L., Collins, F.S., Connell, J.M., Cooper, C., Smith, G.D., Dennison, E.M., Deodhar, P., Elliott, P., Erdos, M.R., Estrada, K., Evans, D.M., Gianniny, L., Gieger, C., Gillson, C.J., Guiducci, C., Hackett, R., Hadley, D., Hall, A.S., Havulinna, A.S., Hebebrand, J., Hofman, A., Isomaa, B., Jacobs, K.B., Johnson, T., Jousilahti, P., Jovanovic, Z., Khaw, K.T., Kraft, P., Kuokkanen, M., Kuusisto, J., Laitinen, J., Lakatta, E.G., Luan, J., Luben, R.N., Mangino, M., McArdle, W.L., Meitinger, T., Mulas, A., Munroe, P.B., Narisu, N., Ness, A.R., Northstone, K., O'Rahilly, S., Purmann, C., Rees, M.G., Ridderstrale, M., Ring, S.M., Rivadeneira, F., Ruokonen, A., Sandhu, M.S., Saramies, J., Scott, L.J., Scuteri, A., Silander, K., Sims, M.A., Song, K., Stephens, J., Stevens, S., Stringham, H.M., Tung, Y.C., Valle, T.T., Van Duijn, C.M., Vimaleswaran, K.S., Vollenweider, P., Waeber, G., Wallace, C., Watanabe, R.M., Waterworth, D.M., Watkins, N.; Wellcome Trust Case Control Consortium, Witteman, J.C., Zeggini, E., Zhai, G., Zillikens, M.C., Altshuler, D., Caulfield, M.J., Chanock, S.J., Farooqi, I.S., Ferrucci, L., Guralnik, J.M., Hattersley, A.T., Hu, F.B., Jarvelin, M.R., Laakso, M., Mooser, V., Ong, K.K., Ouwehand, W.H., Salomaa, V., Samani, N.J., Spector, T.D., Tuomi, T., Tuomilehto, J., Uda, M., Uitterlinden, A.G., Wareham, N.J., Deloukas, P., Frayling, T.M., Groop, L.C., Hayes, R.B., Hunter, D.J., Mohlke, K.L., Peltonen, L., Schlessinger, D., Strachan, D.P., Wichmann, H.E., McCarthy, M.I., Boehnke, M., Barroso, I., Abecasis, G.R., and Hirschhorn, J.N.; Genetic Investigation of ANthropometric Traits Consortium. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34. 

저자의 다른 논문 :

LOADING...

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로