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Fisetin에 의한 비만세포 Th2 사이토카인 발현 하향 조절
Down-regulation of T Helper 2-Associated Cytokine Expression by Fisetin 원문보기

약학회지 = Yakhak hoeji, v.56 no.5, 2012년, pp.326 - 332  

윤수정 (숙명여자대학교 약학대학) ,  표명윤 (숙명여자대학교 약학대학)

Abstract AI-Helper 아이콘AI-Helper

Mast cells play pivotal pathologic roles in allergic disease involving T helper 2 (Th2) cytokine such as interleukin (IL)-4 and IL-13. Fisetin has been known as an anti-allergic agent having inhibitory effects on the IL-4 and IL-13 gene expressions in inflammatory immune cells. However, its molecula...

주제어

참고문헌 (27)

  1. Grimbaldeston, M. A., Metz, M., Yu, M., Tsai, M. and Galli, S. J. : Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses. Curr. Opin. Immunol. 18, 751 (2006). 

  2. Galli, S. J. : Mast cells and basophils. Curr. Opin. Hematol. 7, 32 (2000). 

  3. Metz, M. and Maurer, M. : Mast cells--key effector cells in immune responses. Trends Immunol. 28, 234 (2007). 

  4. Galli, S. J., Nakae, S. and Tsai, M. : Mast cells in the development of adaptive immune responses. Nat. Immunol. 6, 135 (2005). 

  5. Venkayya, R., Lam, M., Willkom, M., Grunig, G., Corry, D. B. and Erle, D. J. : The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am. J. Respir. Cell. Mol. Biol. 26, 202 (2002). 

  6. Brightling, C. E., Symon, F. A., Holgate, S. T., Wardlaw, A. J., Pavord, I. D. and Bradding, P. : Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin. Exp. Allergy 33, 1711 (2003). 

  7. Wills-Karp, M. and Chiaramonte, M. : Interleukin-13 in asthma. Curr. Opin. Pulm. Med. 9, 21 (2003). 

  8. Walter, D. M., McIntire, J. J., Berry, G., McKenzie, A. N., Donaldson, D. D., DeKruyff, R. H. and Umetsu, D. T. : Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167, 4668 (2001). 

  9. Klein, M., Klein-Hessling, S., Palmetshofer, A., Serfling, E., Tertilt, C., Bopp, T., Heib, V., Becker, M., Taube, C., Schild, H., Schmitt, E. and Stassen, M. : Specific and redundant roles for NFAT transcription factors in the expression of mast cellderived cytokines. J. Immunol. 177, 6667 (2006). 

  10. Weiss, D. L., Hural, J., Tara, D., Timmerman, L. A., Henkel, G. and Brown, M. A. : Nuclear factor of activated T cells is associated with a mast cell interleukin 4 transcription complex. Mol. Cell. Biol. 16, 228 (1996). 

  11. Lorentz, A., Klopp, I., Gebhardt, T., Manns, M. P. and Bischoff, S. C. : Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells. J. Allergy Clin. Immunol. 111, 1062 (2003). 

  12. Yamashita, K., Gon, Y., Shimokawa, T., Nunomura, S., Endo, D., Miyata, N., Hashimoto, S., Van Lint, J. and Ra, C. : High affinity receptor for IgE stimulation activates protein kinase D augmenting activator protein-1 activity for cytokine producing in mast cells. Int. Immunopharmacol. 10, 277 (2010). 

  13. Kwan, M., Powell, D. R., Nachman, T. Y. and Brown, M. A. : An intron GATA-binding site regulates chromatin accessibility and is essential for IL-4 gene expression in mast cells. Eur. J. Immunol. 35, 1267 (2005). 

  14. Masuda, A., Yoshikai, Y., Kume, H. and Matsuguchi, T. : The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells. J. Immunol. 173, 5564 (2004). 

  15. Suh, Y., Afaq, F., Johnson, J. J. and Mukhtar, H. : A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. Carcinogenesis 30, 300 (2009). 

  16. Arai, Y., Watanabe, S., Kimira, M., Shimoi, K., Mochizuki, R. and Kinae, N. : Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J. Nutr. 130, 2243 (2000). 

  17. Nagai, K., Takahashi, Y., Mikami, I., Fukusima, T., Oike, H. and Kobori, M. : The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes. Br. J. Pharmacol. 158, 907 (2009). 

  18. Higa, S., Hirano, T., Kotani, M., Matsumoto, M., Fujita, A., Suemura, M., Kawase, I. and Tanaka, T. : Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J. Allergy Clin. Immunol. 111, 1299 (2003). 

  19. Jin, M., Park, S. and Pyo, M. Y. : Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. Biol. Pharm. Bull. 32, 1875 (2009). 

  20. Wu, X., McKenna, M. A., Feng, X., Nagy, T. R. and McDonald, J. M. : Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology 144, 5545 (2003). 

  21. Choi, J. J., Park, B. K., Song, G. Y., Kim, J. S., Kim, J. H., Kim, D. H. and Jin, M. : Establishment of an in vitro test system to evaluate the down-regulatory activities of natural products on IL-4. Arch. Pharm. Res. 30, 1102 (2007). 

  22. Garcia, V., Arts, I. C., Sterne, J. A., Thompson, R. L. and Shaheen, S. O. : Dietary intake of flavonoids and asthma in adults. Eur. Respir. J. 26, 449 (2005). 

  23. Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H., Heliovaara, M., Reunanen, A., Hakulinen, T. and Aromaa, A. : Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76, 560 (2002). 

  24. Kotani, M., Matsumoto, M., Fujita, A., Higa, S., Wang, W., Suemura, M., Kishimoto, T. and Tanaka, T. : Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. Allergy Clin. Immunol. 106, 159 (2000). 

  25. Park, H. H., Lee, S., Oh, J. M., Lee, M. S., Yoon, K. H., Park, B. H., Kim, J. W., Song, H. and Kim, S. H. : Anti-inflammatory activity of fisetin in human mast cells (HMC-1). Pharmacol. Res. 55, 31 (2007). 

  26. Masuda, A., Hashimoto, K., Yokoi, T., Doi, T., Kodama, T., Kume, H., Ohno, K. and Matsuguchi, T. : Essential role of GATA transcriptional factors in the activation of mast cells. J. Immunol. 178, 360 (2007). 

  27. Monticelli, S., Solymar, D. C. and Rao, A. : Role of NFAT proteins in IL13 gene transcription in mast cells. J. Biol. Chem. 279, 36210 (2004). 

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