The Forsythiae fructus is described to be used as an antiinflammatory agent, diuretics, antidotes, antibacterials and so on in oriental literatures. In order to investigate the efficacy of Forsythiae viridissima (Oleaceae), the methanol extract and its fractions have been evaluated for the acute tox...
The Forsythiae fructus is described to be used as an antiinflammatory agent, diuretics, antidotes, antibacterials and so on in oriental literatures. In order to investigate the efficacy of Forsythiae viridissima (Oleaceae), the methanol extract and its fractions have been evaluated for the acute toxicity, antiinflammatory, analgesic and spasmolytic activity in animals. Furthermore, its fractions were evaluated for antiinflammatory and spasmolytic activity. The results obtained were as followings ; 1. The acute toxicity of the methanol extract was very weak: The MLD was more than 4,000mg/kg, p. o. and 3,000mg/kg, i. p. in mice. 2. The methanol extract showed significant antiinflammatory action in the carrageen in induced pedal edema in rats at a dose of 1,120mg/kg, The chloroform and butanol fractions of methanol extract showed significant antiinflammatory activity at the doses of 1,720 and 530mg/kg, respectively. 3. The methanol extract significantly inhibited the leucocyte emigration into the CMC-pouch at the doses of 20 and 60mg/rat, s. c. 4. The methanol extract did not show a notable analgesic effect at the doses of 300 and 900mg/kg, p. o., respectively, in mice. 5. The methanol extract at a concentration of 1×10^(-3)g/ml inhibited completely the contraction produced by serotonin (1×10^(-6)g/ml) and by acetylcholine (1×10^(-8)g/ml) in isolated rat fundus. Through fractionation of the methanol extract, it was observed that the spasmolytic action was most potent in the chloroform fraction. 6. The methanol extract at the concentration of 3×10^(-4)g/ml inhibited the spontaneous movement and the contraction produced by oxytocin (1×10^(-5) I.U./ml) in estrogenized rat uterus. These results might be concluded that the methanol extract of Forsythiae fructus showed significant antiinflammatory activity in the acute and subacute antiinflammatory model in rats. Furthermore, through fractionation procedure, it was found that the active components were easily soluble in chloroform and butanol. It is also noted that the extracts had spasmolytic activities in the rat fundus and uterus.
The Forsythiae fructus is described to be used as an antiinflammatory agent, diuretics, antidotes, antibacterials and so on in oriental literatures. In order to investigate the efficacy of Forsythiae viridissima (Oleaceae), the methanol extract and its fractions have been evaluated for the acute toxicity, antiinflammatory, analgesic and spasmolytic activity in animals. Furthermore, its fractions were evaluated for antiinflammatory and spasmolytic activity. The results obtained were as followings ; 1. The acute toxicity of the methanol extract was very weak: The MLD was more than 4,000mg/kg, p. o. and 3,000mg/kg, i. p. in mice. 2. The methanol extract showed significant antiinflammatory action in the carrageen in induced pedal edema in rats at a dose of 1,120mg/kg, The chloroform and butanol fractions of methanol extract showed significant antiinflammatory activity at the doses of 1,720 and 530mg/kg, respectively. 3. The methanol extract significantly inhibited the leucocyte emigration into the CMC-pouch at the doses of 20 and 60mg/rat, s. c. 4. The methanol extract did not show a notable analgesic effect at the doses of 300 and 900mg/kg, p. o., respectively, in mice. 5. The methanol extract at a concentration of 1×10^(-3)g/ml inhibited completely the contraction produced by serotonin (1×10^(-6)g/ml) and by acetylcholine (1×10^(-8)g/ml) in isolated rat fundus. Through fractionation of the methanol extract, it was observed that the spasmolytic action was most potent in the chloroform fraction. 6. The methanol extract at the concentration of 3×10^(-4)g/ml inhibited the spontaneous movement and the contraction produced by oxytocin (1×10^(-5) I.U./ml) in estrogenized rat uterus. These results might be concluded that the methanol extract of Forsythiae fructus showed significant antiinflammatory activity in the acute and subacute antiinflammatory model in rats. Furthermore, through fractionation procedure, it was found that the active components were easily soluble in chloroform and butanol. It is also noted that the extracts had spasmolytic activities in the rat fundus and uterus.
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