Abstract ▼ AI-Helper

The first report of MRSA with reduced susceptibitlity to vancomycin from Japan in 1997 had raised the threat of incurable staphylococcal infections and caused the urgence of developing new antibiotics coping these bacteria. Many herbs have historically been used to treat those infections caused bact...

The first report of MRSA with reduced susceptibitlity to vancomycin from Japan in 1997 had raised the threat of incurable staphylococcal infections and caused the urgence of developing new antibiotics coping these bacteria. Many herbs have historically been used to treat those infections caused bacteria that are now antibiotic resistant. In this study, extracts from roots of Paeonia japonica MIYABE et TAKEDA were examined for antimicrobial activity against MRSA, Candida albicans, gram positive and negative bacteria. Dichloromethane extract which had showed highest antimicrobial activity was fractionated and one of the three fraction collected through silica gel column chromatography was re-fractionated. A fraction in crystall was requested for mass spectrometry and results revealed that there were six materials : propanal(2.9%), cytidine(13.1%), hexadecanoic acid(3.8%), chelst-5-en-3-ol(67.3%), octadecanoic acis(10.3%) and a material unidentified(2.7%). Results showed that dichloromethane extract which had broad antimicrobial spectrum against MRSA, Candida albicans and other gram positve and negative bacteria could a candidate for new antimicrobial agent.

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