Abstract ▼ AI-Helper

Purpose : The purpose of this study was to evaluate the types of lymphadenitis after BCG vaccination and the effect of local rifampicin instillation to suppurative BCG lymphadenitis.
Methods : A total of thirty two otherwise healthy infants with suppurative BCG lymphadenitis were enrolled in thi...

Purpose : The purpose of this study was to evaluate the types of lymphadenitis after BCG vaccination and the effect of local rifampicin instillation to suppurative BCG lymphadenitis.
Methods : A total of thirty two otherwise healthy infants with suppurative BCG lymphadenitis were enrolled in this study, who visited the Department of Pediatrics of Chonbuk National University Hospital, from March 2002 through June 2004. They were treated with needle aspiration and local rifampicin instillation. From our data, we investigated when the lymphadenitis became suppurative, accompanying clinical manifestations and the treatment effects.
Results : Of the 32 infants, 19 were male and 13 were female. They were born full term babies except one with gestational age of 30 weeks. They received intradermal administration, mostly on left deltoid area(96.9%), with BCG vaccine of Pasteure strain. Regional lymphadenitis occurred between 1 month and 10 months 2 weeks after vaccination, and most commonly 3 months after vaccination (28.1%). Among the infants, 87.5% had unilocular lesion but 12.5% had more than one enlarged lymph node. Lymphadenitis presented in left axillary area(75%), left supuraclaviclular area, and left scapular area ; there was one case of the right inguinal lymph node involvement who had been vaccinated on right buttock. The numbers of rifampicin instillation were one time in 17 cases(53.1%), 2 times in 13 cases(40.6%), and 3 times in 2 cases(6.3%). All infants enrolled in this study recovered completely without complication.
Conclusion : The regional lymphadenitis is the most common complication in infants who receive intradermal BCG vaccination. This study supports that in suppurative BCG lymphadenitis the needle aspiration and local rifampicin instillation is very effective and it can be a more economical treatment modality.

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