본 연구에서는 혈중 cholesterol을 저하시키는데 있어서 좋은 효과를 보이는 물질인 β-sitosterol과 succinic anhydride를 이용하여 β-sitosterol-3-hemisuccinate ester를 합성하고, thionyl chloride를 사용하여 activation 시킨 뒤 최근에 많은 관심과 연구가 진행 중인 flavonoid계 화합물인 ...
본 연구에서는 혈중 cholesterol을 저하시키는데 있어서 좋은 효과를 보이는 물질인 β-sitosterol과 succinic anhydride를 이용하여 β-sitosterol-3-hemisuccinate ester를 합성하고, thionyl chloride를 사용하여 activation 시킨 뒤 최근에 많은 관심과 연구가 진행 중인 flavonoid계 화합물인 hesperetin, naringenin, quercetin등과 결합시켜, 새로운 형태의 cholesterol 저하제의 후보물질로서 BIO-FM41～47 등을 선택적이고 효율적인 방법으로 합성하였다.
본 연구에서는 혈중 cholesterol을 저하시키는데 있어서 좋은 효과를 보이는 물질인 β-sitosterol과 succinic anhydride를 이용하여 β-sitosterol-3-hemisuccinate ester를 합성하고, thionyl chloride를 사용하여 activation 시킨 뒤 최근에 많은 관심과 연구가 진행 중인 flavonoid계 화합물인 hesperetin, naringenin, quercetin등과 결합시켜, 새로운 형태의 cholesterol 저하제의 후보물질로서 BIO-FM41～47 등을 선택적이고 효율적인 방법으로 합성하였다.
Cholesterol is an important part of a healthy body because it is used to form cell membranes, some hormones and is needed for other functions. But hypercholesterolemia, a high level of cholesterol in the blood, is a major risk factor for coronary heart disease(CHD), which leads to heart attack. It w...
Cholesterol is an important part of a healthy body because it is used to form cell membranes, some hormones and is needed for other functions. But hypercholesterolemia, a high level of cholesterol in the blood, is a major risk factor for coronary heart disease(CHD), which leads to heart attack. It was known that β-sitosterol inhibits the absorption of dietary and endogenously produced cholesterol from the small intestine, reducing blood cholesterol concentrations both in animal models and in humans. Flavonoids are most commonly known for their antioxidant activity. They also have been recognized for antibacterial, anti-inflammatory, antiallergic, antimutagenic, antiviral, antineoplastic, anti-thrombotic, and vasodilatory activity. In this study, new phytosterol derivatives having flavonoid were synthesized as new cholesterol lowering candidates. The β-sitosterol-3-hemisuccinate ester was prepared by the reaction of β-sitosterol and succinic anhydride in toluene with a catalytic amount of DMAP. The β-sitosterol-3-hemisuccinate ester was activated by chlorination with SOCl2 and then finally the reaction of activated β-sitosterol-3-hemisuccinate ester with flavonoids in THF in the presence of prydine gave the new phytosterol-flavonoid conjugates in good yields.
Cholesterol is an important part of a healthy body because it is used to form cell membranes, some hormones and is needed for other functions. But hypercholesterolemia, a high level of cholesterol in the blood, is a major risk factor for coronary heart disease(CHD), which leads to heart attack. It was known that β-sitosterol inhibits the absorption of dietary and endogenously produced cholesterol from the small intestine, reducing blood cholesterol concentrations both in animal models and in humans. Flavonoids are most commonly known for their antioxidant activity. They also have been recognized for antibacterial, anti-inflammatory, antiallergic, antimutagenic, antiviral, antineoplastic, anti-thrombotic, and vasodilatory activity. In this study, new phytosterol derivatives having flavonoid were synthesized as new cholesterol lowering candidates. The β-sitosterol-3-hemisuccinate ester was prepared by the reaction of β-sitosterol and succinic anhydride in toluene with a catalytic amount of DMAP. The β-sitosterol-3-hemisuccinate ester was activated by chlorination with SOCl2 and then finally the reaction of activated β-sitosterol-3-hemisuccinate ester with flavonoids in THF in the presence of prydine gave the new phytosterol-flavonoid conjugates in good yields.
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