LPS로 활성화된 복강 대식세포에서 麻黃이 配伍된 10種 처방의 NO 억제 효과 Inhibitory Effect of Ten Kinds of Herbal Medicine Including Ephedrae Herba on Nitric Oxide in LPS-induced Murine Peritoneal Macrophage원문보기
Background and Objective :
Herba Ephedrae(麻黃, Mahwang) triggers the effects as dispelling superficial pathogens and removing cold syndrome, ventilaing the lung and relieving asthma, inducing diuresis and reducing edema or swelling so that it could treat headache, nasal obstruction, restless pain of ...
Background and Objective :
Herba Ephedrae(麻黃, Mahwang) triggers the effects as dispelling superficial pathogens and removing cold syndrome, ventilaing the lung and relieving asthma, inducing diuresis and reducing edema or swelling so that it could treat headache, nasal obstruction, restless pain of joints, cough and shortness of breath, edema caused by wind pathogen, difficulty in urination and numbness in skin and itching syndrome and so on.
So, we tested the inhibitory effects of Nitric Oxide(NO) with Herba Ephedrae and ten kinds of Herbal medicine combined with Herba Ephedrae(Worlbikachul-Tang,越婢加朮湯; Mahaengkamsuk-Tang,麻杏甘石湯; Shinbi-Tang,神秘湯; Mahwangbujaseshin-Tang,麻黃附子細辛湯;
Euiin-Tang,薏苡仁湯; Galgeun-Tang,葛根湯; Mahaengeuigam-Tang,麻杏薏甘湯; Mahwang-Tang,麻黃湯; Socheongryong-Tang,小靑龍湯; Gaemagakban-Tang,桂麻各半湯) to find out whether Herba Ephedrae, solely used, and Herbal medicine in which this was included, have anti-inflammatory effects on RAW264.7 cells.
Results and Conclusion :
1. We carried out MTT assay on Herba Ephedrae and those decoctions including this in order to determine whether they accommodate cotytoxicity. The results were that Worlbikachul-Tang, Mahaengkamsuk- Tang, Mahwangbujaseshin-Tang, Mahaengeuigam-Tang, Mahwang-Tang, Socheongryong-Tang and Gaemagakban-Tang showed no cytotoxicity on RAW264.7 with 0.1mg/ml and 0.5mg/ml dosages of decoctions but displayed cytotoxicity on the cell with 1mg/ml. Solely used Herba Ephedrae, Shinbi-Tang, Euiin-Tang and Galgeun-Tang exhibited cytotoxicity beyond the concentration of 0.5mg/ml.
2. Worlbikachul-Tang, Mahaengkamsuk-Tang, Shinbi-Tang, Mahwangbujaseshin- Tang, Euiin-Tang, Galgeun-Tang, Mahaengeuigam-Tang, Mahwang-Tang and Socheongryong-Tang showed inhibition of NO production but solely used Herba Ephedrae and Gaemagakban-Tang did not exhibit such reaction.
Background and Objective :
Herba Ephedrae(麻黃, Mahwang) triggers the effects as dispelling superficial pathogens and removing cold syndrome, ventilaing the lung and relieving asthma, inducing diuresis and reducing edema or swelling so that it could treat headache, nasal obstruction, restless pain of joints, cough and shortness of breath, edema caused by wind pathogen, difficulty in urination and numbness in skin and itching syndrome and so on.
So, we tested the inhibitory effects of Nitric Oxide(NO) with Herba Ephedrae and ten kinds of Herbal medicine combined with Herba Ephedrae(Worlbikachul-Tang,越婢加朮湯; Mahaengkamsuk-Tang,麻杏甘石湯; Shinbi-Tang,神秘湯; Mahwangbujaseshin-Tang,麻黃附子細辛湯;
Euiin-Tang,薏苡仁湯; Galgeun-Tang,葛根湯; Mahaengeuigam-Tang,麻杏薏甘湯; Mahwang-Tang,麻黃湯; Socheongryong-Tang,小靑龍湯; Gaemagakban-Tang,桂麻各半湯) to find out whether Herba Ephedrae, solely used, and Herbal medicine in which this was included, have anti-inflammatory effects on RAW264.7 cells.
Results and Conclusion :
1. We carried out MTT assay on Herba Ephedrae and those decoctions including this in order to determine whether they accommodate cotytoxicity. The results were that Worlbikachul-Tang, Mahaengkamsuk- Tang, Mahwangbujaseshin-Tang, Mahaengeuigam-Tang, Mahwang-Tang, Socheongryong-Tang and Gaemagakban-Tang showed no cytotoxicity on RAW264.7 with 0.1mg/ml and 0.5mg/ml dosages of decoctions but displayed cytotoxicity on the cell with 1mg/ml. Solely used Herba Ephedrae, Shinbi-Tang, Euiin-Tang and Galgeun-Tang exhibited cytotoxicity beyond the concentration of 0.5mg/ml.
2. Worlbikachul-Tang, Mahaengkamsuk-Tang, Shinbi-Tang, Mahwangbujaseshin- Tang, Euiin-Tang, Galgeun-Tang, Mahaengeuigam-Tang, Mahwang-Tang and Socheongryong-Tang showed inhibition of NO production but solely used Herba Ephedrae and Gaemagakban-Tang did not exhibit such reaction.
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