Caragana sinica (Buchoz) Rehd. (Fabaceae), a deciduous shrub, is widely distributed in Korea, China and Japan. Its dried roots have been used as a folk medicine for the treatment of asthenia syndrome, hypertension, leukorrhagia, bruises and contused wounds. It has been reported that the genus of Car...
Caragana sinica (Buchoz) Rehd. (Fabaceae), a deciduous shrub, is widely distributed in Korea, China and Japan. Its dried roots have been used as a folk medicine for the treatment of asthenia syndrome, hypertension, leukorrhagia, bruises and contused wounds. It has been reported that the genus of Caragana is a rich source of oligostilbenes. In the course of search for bioactive compounds from plants, a MeOH extract of the dried roots of Caragana sinica was partitioned by successive extraction with CH2Cl2, EtOAc, and H2O. The EtOAc-soluble fraction was subjected to sequential column chromatography on silica gel, RP-18, and preparative HPLC to yield two new oligostilbenes, and eight known compounds such as kobophenol A (1), (+)-a-viniferin (2), (+)-ampelopsin F (3), (-)-pallidol (4), viniferether C (5), (+)-isoampelopsin F (6), miyabenol C (7), carapheol B (8), carasinaurone (9), and viniferether C (10). The structures of these compounds were determined on the basis of chemical evidence and extensive spectroscopic analysis including 1D-NMR, 2D-NMR and ESI-MS (HRESI-MS). These compounds were evaluated for their antioxidant activities in DPPH system. The results demonstrated that two new oligostilbenes (5 and 10) and carasinaurone (9) showed weak antioxidant activity.
Caragana sinica (Buchoz) Rehd. (Fabaceae), a deciduous shrub, is widely distributed in Korea, China and Japan. Its dried roots have been used as a folk medicine for the treatment of asthenia syndrome, hypertension, leukorrhagia, bruises and contused wounds. It has been reported that the genus of Caragana is a rich source of oligostilbenes. In the course of search for bioactive compounds from plants, a MeOH extract of the dried roots of Caragana sinica was partitioned by successive extraction with CH2Cl2, EtOAc, and H2O. The EtOAc-soluble fraction was subjected to sequential column chromatography on silica gel, RP-18, and preparative HPLC to yield two new oligostilbenes, and eight known compounds such as kobophenol A (1), (+)-a-viniferin (2), (+)-ampelopsin F (3), (-)-pallidol (4), viniferether C (5), (+)-isoampelopsin F (6), miyabenol C (7), carapheol B (8), carasinaurone (9), and viniferether C (10). The structures of these compounds were determined on the basis of chemical evidence and extensive spectroscopic analysis including 1D-NMR, 2D-NMR and ESI-MS (HRESI-MS). These compounds were evaluated for their antioxidant activities in DPPH system. The results demonstrated that two new oligostilbenes (5 and 10) and carasinaurone (9) showed weak antioxidant activity.
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