Background: C-reactive protein (CRP), an acute phase serum globulin, is produced by hepatocytes in response to various nonspecific stimuli such as microbial infection, tissue necrosis, or neoplasm. The aim of this study is to clarify to what extent pyogenic meningitis could be distinguished from ase...
Background: C-reactive protein (CRP), an acute phase serum globulin, is produced by hepatocytes in response to various nonspecific stimuli such as microbial infection, tissue necrosis, or neoplasm. The aim of this study is to clarify to what extent pyogenic meningitis could be distinguished from aseptic or tuberculous meningitis through CRP levels in adults. Methods: From January 1999 to March 2009, a total of 113 adult cases (aged 15-98 years), including patients with pyogenic meningitis (n = 14), aseptic meningitis (n = 84), and tuberculous (Tb) meningitis (n = 15), were retrospectively analyzed based on data from the initial examination. We examined common clinical CSF parameters, including total white cell count, protein level, and glucose concentration. Serum analyses included white blood cell (WBC) count, glucose level, and serum CRP in peripheral blood obtained at the same time as the first lumbar puncture. Results: 9 of 14 patients with pyogenic meningitis showed blood CRP levels ≥10 mg/dl, whereas CRP levels <10 mg/dl were observed in all patients with aseptic or Tb meningitis. Using a serum CRP level of ≥10 mg/dl as a positive discriminatory factor for pyogenic meningitis resulted in sensitivity and specificity values of 0.71 and 1.0, respectively. To better discriminate pyogenic from nonpyogenic meningitis, we analyzed changes in serum CRP and cerebrospimenifluid (CSF) protein level, glucose concentration, white blood cell(WBC) count using one-way analysis of variance (ANOVA) and concluded that blood CRP effectively differentiates pyogenic meningitis from virenimeningitis or tuberculous meningitis at admission. Conclusion: This study suggests that serum CRP analysis, which is both simple and inexpensive, is helpful to differentiate pyogenic meningitis from other aseptic or tuberculous meningitis.
Background: C-reactive protein (CRP), an acute phase serum globulin, is produced by hepatocytes in response to various nonspecific stimuli such as microbial infection, tissue necrosis, or neoplasm. The aim of this study is to clarify to what extent pyogenic meningitis could be distinguished from aseptic or tuberculous meningitis through CRP levels in adults. Methods: From January 1999 to March 2009, a total of 113 adult cases (aged 15-98 years), including patients with pyogenic meningitis (n = 14), aseptic meningitis (n = 84), and tuberculous (Tb) meningitis (n = 15), were retrospectively analyzed based on data from the initial examination. We examined common clinical CSF parameters, including total white cell count, protein level, and glucose concentration. Serum analyses included white blood cell (WBC) count, glucose level, and serum CRP in peripheral blood obtained at the same time as the first lumbar puncture. Results: 9 of 14 patients with pyogenic meningitis showed blood CRP levels ≥10 mg/dl, whereas CRP levels <10 mg/dl were observed in all patients with aseptic or Tb meningitis. Using a serum CRP level of ≥10 mg/dl as a positive discriminatory factor for pyogenic meningitis resulted in sensitivity and specificity values of 0.71 and 1.0, respectively. To better discriminate pyogenic from nonpyogenic meningitis, we analyzed changes in serum CRP and cerebrospimenifluid (CSF) protein level, glucose concentration, white blood cell(WBC) count using one-way analysis of variance (ANOVA) and concluded that blood CRP effectively differentiates pyogenic meningitis from virenimeningitis or tuberculous meningitis at admission. Conclusion: This study suggests that serum CRP analysis, which is both simple and inexpensive, is helpful to differentiate pyogenic meningitis from other aseptic or tuberculous meningitis.
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