Background: Hypertension should be treated and controlled well because of its complications related to cardiovascular diseases. Though, it is difficult for patients to maintain normal blood pressure evenly due to various responses to antihypertensive drugs. In Korea, sasang constitution medicine (SC...
Background: Hypertension should be treated and controlled well because of its complications related to cardiovascular diseases. Though, it is difficult for patients to maintain normal blood pressure evenly due to various responses to antihypertensive drugs. In Korea, sasang constitution medicine (SCM) has been developed and well accepted by culture. Sasang constitution medicine as Korean traditional medicine suggests that treatment be differentiated by sasang constitution classification (So-yang, So-eum, Tae-yang, Tae-eum), compared that treatment is applied equally according to its indication in western medicine. Studies regarding two different medicines have been rarely although they have lived together for a long time. Therefore, we evaluated blood pressure among patients taking Angiotensin II Receptor Blockers or Calcium Channel blockers commonly used in Korea to study whether sasang constitutional classification may cause therapeutic differences of antihypertensive agents. Methods: From April 2006 to June 2012, we retrospectively studied hypertensive patients with sasang constitutional classification in Kyunghee university hospital at Gangdong. We collected information regarding sex, age, underlying diseases, antihypertensive drugs (Angiotensin II receptor blocker; ARB, Calcium channel blocker; CCB, ARB+CCB), blood pressure (BP) by reviewing electronic medical record. Patients not having blood pressure (base or follow-up) or changing to other classes of antihypertensive drugs during follow-up were excluded. Statistical analysis was used by SPSS (Ver.12.0) and Microsoft Excel 2007 to analyze cross-tabulation analysis, independence test, one-way ANOVA and two-way ANOVA). P values less than 0.05 were statistically significant. Results: We selected total 573 patients (So-yang (SY): 165, So-eum (SE): 158, Tae-yang (TY): 0, Tae-eum (TE): 250). CCB was the most used, followed by ARB+CCB, ARB in all three types. BP reduction in 1 month after starting medication was SY (ARB: -12.4/-4.7, CCB: -12.3/-5.4, ARB+CCB: -15.6/-6.7), SE (ARB: -12.3/-2.5, CCB: -13.0/-2.3, ARB+CCB: -18.4/-8.1), TE (ARB: -8.6/-1.8, CCB: -10.8/-6.0, ARB+CCB: -20.2/-6.7) (Drug(P ≤0.05 / P >0.05), Type (P >0.05/ P >0.05)). In addition, reduction in blood pressure between female and male was Female (ARB: -12.9/-3.7, CCB: -10.9/-5.0, ARB+CCB: -19.7/-7.3), Male (ARB: -9.5/-1.6, CCB: -13.5/-6.2, ARB+CCB: -16.2/-7.8) (Drug (P ≤0.05/ P ≤0.05), Sex (P >0.05/ P >0.05)). Reduction in blood pressure between under 65 years and over 65 was under 65 years (ARB: -10.5/-5.0, CCB: -10.8/-5.7, ARB+CCB: -12.1/-4.9), over 65 years (ARB: (-10.5/-1.3, CCB: -12.5/-4.3, ARB+CCB: -23.3/-8.9) (Drug (P ≤0.05/ P >0.05), Age (P >0.05/ P >0.05)). Conclusion: According to our study results, differences of reduction in blood pressure were caused by not Sasang constitution, age, gender but drugs. Therefore, current antihypertensive pharmacotherapy regardless of Sasang constitution was appropriate for hypertensive patients. However, further larger scale or prospective studies are required in order to confirm these results.
Background: Hypertension should be treated and controlled well because of its complications related to cardiovascular diseases. Though, it is difficult for patients to maintain normal blood pressure evenly due to various responses to antihypertensive drugs. In Korea, sasang constitution medicine (SCM) has been developed and well accepted by culture. Sasang constitution medicine as Korean traditional medicine suggests that treatment be differentiated by sasang constitution classification (So-yang, So-eum, Tae-yang, Tae-eum), compared that treatment is applied equally according to its indication in western medicine. Studies regarding two different medicines have been rarely although they have lived together for a long time. Therefore, we evaluated blood pressure among patients taking Angiotensin II Receptor Blockers or Calcium Channel blockers commonly used in Korea to study whether sasang constitutional classification may cause therapeutic differences of antihypertensive agents. Methods: From April 2006 to June 2012, we retrospectively studied hypertensive patients with sasang constitutional classification in Kyunghee university hospital at Gangdong. We collected information regarding sex, age, underlying diseases, antihypertensive drugs (Angiotensin II receptor blocker; ARB, Calcium channel blocker; CCB, ARB+CCB), blood pressure (BP) by reviewing electronic medical record. Patients not having blood pressure (base or follow-up) or changing to other classes of antihypertensive drugs during follow-up were excluded. Statistical analysis was used by SPSS (Ver.12.0) and Microsoft Excel 2007 to analyze cross-tabulation analysis, independence test, one-way ANOVA and two-way ANOVA). P values less than 0.05 were statistically significant. Results: We selected total 573 patients (So-yang (SY): 165, So-eum (SE): 158, Tae-yang (TY): 0, Tae-eum (TE): 250). CCB was the most used, followed by ARB+CCB, ARB in all three types. BP reduction in 1 month after starting medication was SY (ARB: -12.4/-4.7, CCB: -12.3/-5.4, ARB+CCB: -15.6/-6.7), SE (ARB: -12.3/-2.5, CCB: -13.0/-2.3, ARB+CCB: -18.4/-8.1), TE (ARB: -8.6/-1.8, CCB: -10.8/-6.0, ARB+CCB: -20.2/-6.7) (Drug(P ≤0.05 / P >0.05), Type (P >0.05/ P >0.05)). In addition, reduction in blood pressure between female and male was Female (ARB: -12.9/-3.7, CCB: -10.9/-5.0, ARB+CCB: -19.7/-7.3), Male (ARB: -9.5/-1.6, CCB: -13.5/-6.2, ARB+CCB: -16.2/-7.8) (Drug (P ≤0.05/ P ≤0.05), Sex (P >0.05/ P >0.05)). Reduction in blood pressure between under 65 years and over 65 was under 65 years (ARB: -10.5/-5.0, CCB: -10.8/-5.7, ARB+CCB: -12.1/-4.9), over 65 years (ARB: (-10.5/-1.3, CCB: -12.5/-4.3, ARB+CCB: -23.3/-8.9) (Drug (P ≤0.05/ P >0.05), Age (P >0.05/ P >0.05)). Conclusion: According to our study results, differences of reduction in blood pressure were caused by not Sasang constitution, age, gender but drugs. Therefore, current antihypertensive pharmacotherapy regardless of Sasang constitution was appropriate for hypertensive patients. However, further larger scale or prospective studies are required in order to confirm these results.
주제어
#Hypertension Sasang Constitution Electronic medical record Antihypertensive drugs Angiotension II receptor blockers Calcium channel blockers
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