Purpose: The object of this study was find out the immunostimulatory effects of Zingiber Officinale (ZR) and synergic effects of mixed formulas consisted of two individual herbal extracts, ZR, Artemisiae Capillaris(AC) or Hovenia dulcis(HR), as compared with that of β-glucan well-known as immune mod...
Purpose: The object of this study was find out the immunostimulatory effects of Zingiber Officinale (ZR) and synergic effects of mixed formulas consisted of two individual herbal extracts, ZR, Artemisiae Capillaris(AC) or Hovenia dulcis(HR), as compared with that of β-glucan well-known as immune modulator, on the cyclophosphamide(CPA) induced immunosuppress mice. Materials and Methods: To induced immunosuppress, twice of CPA injected intraperitoneally at 3, 1 day before test article administration, respectively. ZR(125, 250 and 500 mg/kg)[Study 1], ZR(500 mg/kg), AC(500 mg/kg), HR(500 mg/kg), ZR:AC(1:1,1:9,9:1), ZR:HR(1:1,1:9,9:1), AC:HR(1:1,1:9,9:1) [study 2] were dosed, 4 times at 12-hr interval starting 24-hr after last CPA treatment.. Results: As results of twice intraperitoneal CPA treatment, the body weight, body gain, WBC count were decreased and sever atrophic changes of spleen and popliteal lymph node were observed histopathological findings. However these CPA induced immunosuppress changes were significantly(p<0.01 or p<0.05) inhibited by treatment of β-glucan, ZR, AC, HR, single formula with 9 types of mixed formulas ac compared with CPA control. Especially, ZR:HR(1:9), AC:HR(1:1,1:9) mixed formulas were significantly(p<0.01 or p<0.05) increased compared with those single formula, ZR, AC or HR, in immunostimulatory effects. And it showed more favorable effects as compared with β-glucan as reference drug. Conclusion: ZR:HR(1:9), AC:HR(1:1,1:9) were significantly (p<0.01 or p<0.05) increase of immunostimulatory effects as compared with those of single formula, ZR, AC or HR on CPA induced immunosuppressive mice. Therefore, appropriated mixed formula consisted of ZR, AC or HR will be favorable synergic immunomodulatory effects on chemtherpy induced immunosuppress.
Purpose: The object of this study was find out the immunostimulatory effects of Zingiber Officinale (ZR) and synergic effects of mixed formulas consisted of two individual herbal extracts, ZR, Artemisiae Capillaris(AC) or Hovenia dulcis(HR), as compared with that of β-glucan well-known as immune modulator, on the cyclophosphamide(CPA) induced immunosuppress mice. Materials and Methods: To induced immunosuppress, twice of CPA injected intraperitoneally at 3, 1 day before test article administration, respectively. ZR(125, 250 and 500 mg/kg)[Study 1], ZR(500 mg/kg), AC(500 mg/kg), HR(500 mg/kg), ZR:AC(1:1,1:9,9:1), ZR:HR(1:1,1:9,9:1), AC:HR(1:1,1:9,9:1) [study 2] were dosed, 4 times at 12-hr interval starting 24-hr after last CPA treatment.. Results: As results of twice intraperitoneal CPA treatment, the body weight, body gain, WBC count were decreased and sever atrophic changes of spleen and popliteal lymph node were observed histopathological findings. However these CPA induced immunosuppress changes were significantly(p<0.01 or p<0.05) inhibited by treatment of β-glucan, ZR, AC, HR, single formula with 9 types of mixed formulas ac compared with CPA control. Especially, ZR:HR(1:9), AC:HR(1:1,1:9) mixed formulas were significantly(p<0.01 or p<0.05) increased compared with those single formula, ZR, AC or HR, in immunostimulatory effects. And it showed more favorable effects as compared with β-glucan as reference drug. Conclusion: ZR:HR(1:9), AC:HR(1:1,1:9) were significantly (p<0.01 or p<0.05) increase of immunostimulatory effects as compared with those of single formula, ZR, AC or HR on CPA induced immunosuppressive mice. Therefore, appropriated mixed formula consisted of ZR, AC or HR will be favorable synergic immunomodulatory effects on chemtherpy induced immunosuppress.
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