Abstract ▼ AI-Helper

Rhodiola dumulosa is a kind of traditional Chinese medicine, with anti-fatigue, anti-oxidation, hepatoprotection, improving blood circulation and other pharmacological properties. As we know, the steroidal and non-steroidal anti-inflammatory drugs are mostly used for treatment purposes. Prolonged us...

Rhodiola dumulosa is a kind of traditional Chinese medicine, with anti-fatigue, anti-oxidation, hepatoprotection, improving blood circulation and other pharmacological properties. As we know, the steroidal and non-steroidal anti-inflammatory drugs are mostly used for treatment purposes. Prolonged use of these conventional anti-inflammatory drugs may produce many side effects, such as leukopenia, gastrointestinal disorders, and humoral disturbances. Therefore, plant extracts with anti-inflammatory and antioxidant potential may greatly contribute to develop new treatment with morless side effects. Despite Rhodiola dumulosa has been used in herbal medicine, there is no extensive study on the anti-inflammatory activity of its extracts. In order to explore its medicinal value with the interaction of further expanding the scope of the application in clinical practice, in this study, anti-inflammatory effect of Rhodiola dumulosa water extracts were investigated.
The inflammatory response model was established by lipopolysaccharide (LPS) stimulated RAW 264.7 mononuclear macrophage. The current study was aimed to investigate the anti-oxidant activity and anti-inflammatory activity of the roots and stems of the herb, and to explore its molecular mechanism of anti-inflammatory action with the aid of inflammatory signal transduction pathway. The results showed that the Rhodiola dumulosa water extracts have significant antioxidant activities as well as they inhibited the expression of IL-6 and IL-1β. In addition, the extracts could inhibit the synthesis of nitric oxide (NO). Moreover the mechanism of LPS induced cytokines and inflammatory mediators were investigated in the signal transduction pathway NF-κB played a key role regulating the results showed that RDW exerts anti-inflammatory effect by down-regulating the expression of iNOS and COX-2 genes through inhibition of MAPK (ERK, JNK and p38) and NF-κB signaling.