Tribulus terrestris has been used in traditional medicine for dizzy, headache, high blood pressure, coated tongue, menstrual irregularity, and pruritus. Previous phytochemical studies on this plant have been reported that it contained phenolic compounds, fatty acids, terpenoids, saponins and lignans...
Tribulus terrestris has been used in traditional medicine for dizzy, headache, high blood pressure, coated tongue, menstrual irregularity, and pruritus. Previous phytochemical studies on this plant have been reported that it contained phenolic compounds, fatty acids, terpenoids, saponins and lignans. As a part of continuing search for the discovery of new bioactive constituents from medicinal plants, the dried fruits of T. terrestris were extracted with MeOH, and partitioned with n-hexane, CH2Cl2, EtOAc, and water, successively. The CH2Cl2 and EtOAc soluble fractions ware purified by several column chromatography including MPLC and preparative HPLC. A new phenolic compound along with 21 known compounds was isolated from the CH2Cl2 and EtOAc soluble fraction of the fruits of T. terrestris. Their structures were elucidated on the basis of spectroscopic methods such as 1D-NMR, 2D-NMR, and HRESI-MS. Additionally, all of isolates were evaluated for their inhibitory effects on LPS-induced NO production in RAW 264.7 cells. Among them, compounds 5, 6, 7, 8, 14, 20 and 22 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values raging from 12.6μM to 46.6μM while aminoguanidine, a positive control, showed an IC50 value of 20.6μM. Accordingly, T. terrestris is worthy of further investigation for its potential as an anti-inflammatory agent.
Tribulus terrestris has been used in traditional medicine for dizzy, headache, high blood pressure, coated tongue, menstrual irregularity, and pruritus. Previous phytochemical studies on this plant have been reported that it contained phenolic compounds, fatty acids, terpenoids, saponins and lignans. As a part of continuing search for the discovery of new bioactive constituents from medicinal plants, the dried fruits of T. terrestris were extracted with MeOH, and partitioned with n-hexane, CH2Cl2, EtOAc, and water, successively. The CH2Cl2 and EtOAc soluble fractions ware purified by several column chromatography including MPLC and preparative HPLC. A new phenolic compound along with 21 known compounds was isolated from the CH2Cl2 and EtOAc soluble fraction of the fruits of T. terrestris. Their structures were elucidated on the basis of spectroscopic methods such as 1D-NMR, 2D-NMR, and HRESI-MS. Additionally, all of isolates were evaluated for their inhibitory effects on LPS-induced NO production in RAW 264.7 cells. Among them, compounds 5, 6, 7, 8, 14, 20 and 22 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values raging from 12.6μM to 46.6μM while aminoguanidine, a positive control, showed an IC50 value of 20.6μM. Accordingly, T. terrestris is worthy of further investigation for its potential as an anti-inflammatory agent.
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#질려자 Tribulus terrestris 질려자의 성분 질려자 구성성분 질려자의 항염증작용
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