Hibiscus syriacus, the national flower of South Korea, has been traditionally used for the treatment of cough and tinea pedis. Anthocyanins, coumarins and naphthalenes are known as the main constituents. It is also reported to have antioxidant, anti-inflammatory, anticancer, and anti-bacterial effec...
Hibiscus syriacus, the national flower of South Korea, has been traditionally used for the treatment of cough and tinea pedis. Anthocyanins, coumarins and naphthalenes are known as the main constituents. It is also reported to have antioxidant, anti-inflammatory, anticancer, and anti-bacterial effects. However, most studies were focused on the flowers and leaves of H. syriacus. Thus, a phytochemical study was conducted to investigate the constituents of H. syriacus roots. Isolation of the n-hexane, CH2Cl2 and EtOAc layers of H. syriacus was performed using a variety of chromatographic techniques and the structures of isolated compounds were determined based on spectral data including 1D, 2D NMR and MS analysis. As a result, fifteen compounds (1-15) were isolated from the roots of H. syriaucus. Among the isolated compounds, three naphthalenes, mukungalenes A-C (1-3), are first reported from nature. Twelve known compounds were identified as five known naphthalenes, syriacusin B (4), syriacusin A (5), parvlfloral A (6), cadalene (7), isohemigossypol-1-methyl ether (8), two alkaloids, trans-N-feruloyltyramine (9), sis-N-feruloyltyramine (10) and five phenolic compounds, 5,6,7,8-tetramethoxycoumarin (11), vanillin (12), benzoic acid (13), veratric acid (14) and vanillic acid (15). Among the isolated compounds, 5 and 6 showed antioxidant activities with an IC50 values of 45.8 μM and 30.4 μM, respectively. This study provides information about the constituents of H. syriacus roots with antioxidant effects.
Hibiscus syriacus, the national flower of South Korea, has been traditionally used for the treatment of cough and tinea pedis. Anthocyanins, coumarins and naphthalenes are known as the main constituents. It is also reported to have antioxidant, anti-inflammatory, anticancer, and anti-bacterial effects. However, most studies were focused on the flowers and leaves of H. syriacus. Thus, a phytochemical study was conducted to investigate the constituents of H. syriacus roots. Isolation of the n-hexane, CH2Cl2 and EtOAc layers of H. syriacus was performed using a variety of chromatographic techniques and the structures of isolated compounds were determined based on spectral data including 1D, 2D NMR and MS analysis. As a result, fifteen compounds (1-15) were isolated from the roots of H. syriaucus. Among the isolated compounds, three naphthalenes, mukungalenes A-C (1-3), are first reported from nature. Twelve known compounds were identified as five known naphthalenes, syriacusin B (4), syriacusin A (5), parvlfloral A (6), cadalene (7), isohemigossypol-1-methyl ether (8), two alkaloids, trans-N-feruloyltyramine (9), sis-N-feruloyltyramine (10) and five phenolic compounds, 5,6,7,8-tetramethoxycoumarin (11), vanillin (12), benzoic acid (13), veratric acid (14) and vanillic acid (15). Among the isolated compounds, 5 and 6 showed antioxidant activities with an IC50 values of 45.8 μM and 30.4 μM, respectively. This study provides information about the constituents of H. syriacus roots with antioxidant effects.
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