Ulmus davidiana var. japonica (Ulmaceae) is widely distributed in Asian countries and its root barks, well-known as yugeunpi, have been used in Korean traditional medicines to treat inflammatory disorders, especially for rhinitis and gastroenteritis. As part of a continuing search for bioactive cons...
Ulmus davidiana var. japonica (Ulmaceae) is widely distributed in Asian countries and its root barks, well-known as yugeunpi, have been used in Korean traditional medicines to treat inflammatory disorders, especially for rhinitis and gastroenteritis. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical investigation of the root barks of U. davidiana var. japonica led to the isolation of one new compound (1) named (2R,3S)-2-ethoxychroman-3,5,7-triol-7-O-β-D-apiofuranoside, along with 22 known compounds: catechin derivatives (2-5), megastigmane glycoside (6), dihydrochalcone glycosides (7 and 8), flavanone glycosides (9 and 10), coumarins (11 and 12), lignan derivatives (13-17), and phenolic compounds (18-23). Compounds 7-14, 16, and 18-23 were isolated from U. davidiana var. japonica for the first time. Among them, 7-14, 16, 18-19, 21, and 23 were first reported in Ulmaceae. The chemical structures of the isolated compounds were unambiguously determined using physical data, spectroscopic evidence, including 1D and 2D NMR spectroscopy experiments, LC/MS analysis and computational method coupled with a statistical procedure (DP4+). The isolated compounds were evaluated for their anti-Helicobacter pylori activity on H. pylori strain 51 and 43504.
Ulmus davidiana var. japonica (Ulmaceae) is widely distributed in Asian countries and its root barks, well-known as yugeunpi, have been used in Korean traditional medicines to treat inflammatory disorders, especially for rhinitis and gastroenteritis. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical investigation of the root barks of U. davidiana var. japonica led to the isolation of one new compound (1) named (2R,3S)-2-ethoxychroman-3,5,7-triol-7-O-β-D-apiofuranoside, along with 22 known compounds: catechin derivatives (2-5), megastigmane glycoside (6), dihydrochalcone glycosides (7 and 8), flavanone glycosides (9 and 10), coumarins (11 and 12), lignan derivatives (13-17), and phenolic compounds (18-23). Compounds 7-14, 16, and 18-23 were isolated from U. davidiana var. japonica for the first time. Among them, 7-14, 16, 18-19, 21, and 23 were first reported in Ulmaceae. The chemical structures of the isolated compounds were unambiguously determined using physical data, spectroscopic evidence, including 1D and 2D NMR spectroscopy experiments, LC/MS analysis and computational method coupled with a statistical procedure (DP4+). The isolated compounds were evaluated for their anti-Helicobacter pylori activity on H. pylori strain 51 and 43504.
주제어
#Ulmus davidiana var. japonica, Ulmaceae, (2R,3S)-2-ethoxychroman-3,5,7-triol-7-O-β-D-apiofuranoside, Helicobacter pylori
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