Recently, as the elderly population grows, the need for prevention and treatment of normal aging increases. The environmental enrichment is well known to be effective in preventing or slowing progression to various neurodegenerative diseases. Also, it is considered that there will have the effect of...
Recently, as the elderly population grows, the need for prevention and treatment of normal aging increases. The environmental enrichment is well known to be effective in preventing or slowing progression to various neurodegenerative diseases. Also, it is considered that there will have the effect of anti-aging in the normal aging process. The purpose of this study is to confirm the effects of environmental enrichment on the normal aging process through the autophagy pathway in aged rat models.
Sprague Dawley(SD) rats were randomly arranged in each of 8-10 rats as Young group(8 weeks), Adult group(12 weeks), Adult+EE group(12 weeks), Aging group(72 weeks), and Aging+EE group(72weeks). Adult+EE group and Aging+EE group were exposed to environmental enrichment for 12 weeks. We identified changes in blood lipid components, muscle strength, cognitive function, and biomarker of aging and autophagy signaling pathway in the hippocampus according to adolescence, adulthood, and old age, and confirmed the effects of environmental enrichment on anti-aging during adulthood and old age.
We found that as we age, the levels of blood lipid and the biomarker of aging, SA-β-gal and IL-6, increased. Muscle strength decreased from adulthood but, cognitive function and the number of neurons reduced from old age. It was found that the changes related to aging occur at different rates in different organs. The environmental enrichment was more effective in the aging group than in the adult group. The Aging+EE group lowered levels of plasma triglyceride, increased grip strength, and improved learning and memory than the Aging group. Also, the Aging+EE group showed decreased expression of SA-β-gal, IL-6, and mTORC and increased expression of Beclin1 and LC3, which are autophagy markers, in the hippocampal CA1 than the Aging group.
Our results suggest that environmental enrichment contributes to anti-aging by increasing the activation of autophagy.
Recently, as the elderly population grows, the need for prevention and treatment of normal aging increases. The environmental enrichment is well known to be effective in preventing or slowing progression to various neurodegenerative diseases. Also, it is considered that there will have the effect of anti-aging in the normal aging process. The purpose of this study is to confirm the effects of environmental enrichment on the normal aging process through the autophagy pathway in aged rat models.
Sprague Dawley(SD) rats were randomly arranged in each of 8-10 rats as Young group(8 weeks), Adult group(12 weeks), Adult+EE group(12 weeks), Aging group(72 weeks), and Aging+EE group(72weeks). Adult+EE group and Aging+EE group were exposed to environmental enrichment for 12 weeks. We identified changes in blood lipid components, muscle strength, cognitive function, and biomarker of aging and autophagy signaling pathway in the hippocampus according to adolescence, adulthood, and old age, and confirmed the effects of environmental enrichment on anti-aging during adulthood and old age.
We found that as we age, the levels of blood lipid and the biomarker of aging, SA-β-gal and IL-6, increased. Muscle strength decreased from adulthood but, cognitive function and the number of neurons reduced from old age. It was found that the changes related to aging occur at different rates in different organs. The environmental enrichment was more effective in the aging group than in the adult group. The Aging+EE group lowered levels of plasma triglyceride, increased grip strength, and improved learning and memory than the Aging group. Also, the Aging+EE group showed decreased expression of SA-β-gal, IL-6, and mTORC and increased expression of Beclin1 and LC3, which are autophagy markers, in the hippocampal CA1 than the Aging group.
Our results suggest that environmental enrichment contributes to anti-aging by increasing the activation of autophagy.
주제어
#Normal aging, Anti-aging, Autophagy, Environmental enrichment
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