Obesity and related diseases are known as a global epidemic. Obesity can lead to many chronic diseases, such as fatty liver, type 2 diabetes, stroke, cardiovascular disease, and even increase the risk of some cancers and depression. The treatment of obesity with energy expenditure (fat), the bioener...
Obesity and related diseases are known as a global epidemic. Obesity can lead to many chronic diseases, such as fatty liver, type 2 diabetes, stroke, cardiovascular disease, and even increase the risk of some cancers and depression. The treatment of obesity with energy expenditure (fat), the bioenergetic pathway, is attractive and may be the most effective route. Artemisinic acid, which is isolated from the well-known anti-malaria herb Artemisia annua (AA) was recently shown to possess anti-adipogenic effects in vitro. In this context, we used C3H10T1/2 cells as a cell model to explore the safety (biological activity and toxicity) of rtemisia annua(AA)in vitro. To investigate the potential anti-obesity molecular mechanisms of Artemisia annua, including its transcription factors, and regulatory pathways in adipocyte differentiation and adipogenesis, and its effects on white fat browning. The effects of Artemisia annua extract on body weight, fat content, volume, blood glucose and insulin resistance were observed in obese rats induced by high-fat diet in vivo.
Obesity and related diseases are known as a global epidemic. Obesity can lead to many chronic diseases, such as fatty liver, type 2 diabetes, stroke, cardiovascular disease, and even increase the risk of some cancers and depression. The treatment of obesity with energy expenditure (fat), the bioenergetic pathway, is attractive and may be the most effective route. Artemisinic acid, which is isolated from the well-known anti-malaria herb Artemisia annua (AA) was recently shown to possess anti-adipogenic effects in vitro. In this context, we used C3H10T1/2 cells as a cell model to explore the safety (biological activity and toxicity) of rtemisia annua(AA)in vitro. To investigate the potential anti-obesity molecular mechanisms of Artemisia annua, including its transcription factors, and regulatory pathways in adipocyte differentiation and adipogenesis, and its effects on white fat browning. The effects of Artemisia annua extract on body weight, fat content, volume, blood glucose and insulin resistance were observed in obese rats induced by high-fat diet in vivo.
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