[논문]Obesity, obesity-related diseases and application of animal model in obesity research An overview

Park, Byung-Sung; Singh, N.K.; Reza, A.M.M.T.

doi:10.12925/jkocs.2013.30.4.622

Obesity, obesity-related diseases and application of animal model in obesity research An overview 원문보기

한국유화학회지 = Journal of oil & applied science, v.30 no.4, 2013년, pp.622 - 634

Park, Byung-Sung (Department of Animal Biotechnology, College of Animal Life Sciences, Kangwon National University) , Singh, N.K. (Department of Animal Biotechnology, College of Animal Life Sciences, Kangwon National University) , Reza, A.M.M.T. (Department of Animal Biotechnology, College of Animal Life Sciences, Kangwon National University)

Abstract ▼ AI-Helper

The multi-origin of obesity and its associated diseases made it's a complex area of biomedical science research and severe health disorder. From the 1970s to onwards this health problem turned to an epidemic without having any report of declining yet and it created a red alert to the health sector. Meanwhile, many animal models have been developed to study the lethal effect of obesity. In consequence, many drugs, therapies and strategies have already been adopted based on the findings of those animal models. However, many complicated things based on molecular and generic mechanism has not been clarified to the date. Thus, it is important to develop a need based animal model for the better understanding and strategic planning to eliminate/avoid the obesity disorder. Therefore, the present review would unveil the pros and cons of presently established animal models for obesity research. In addition, it would indicate the required turning direction for further obesity and obesity based disease research.

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성능/효과

The dog model of human obesity research could be able to unveil the genetic contribution to the problem [76]. In conclusion, the successful application of animal model in obesity research revealed many unknown question and directed towards the solution of human obesity and it related diseases. It opened the door of discovering many treatments, therapies, cures to get relief of obesity disorders.

후속연구

Thus, for the understanding of obesity and its interactions with aging, the small animal models might not give accurate observations. For the proper understanding of the mechanism of obesity and associated diseases in the later stages of life, for having accurate measure to avoid obesity in the old ages, the future research effort should be given to establish an animal model which had comparatively larger life span like human being. In continuation, instead of doing short-term study, it could be recommended to conduct long-term investigation to have a concrete understanding and checklist of safety measures to be taken at different stages of age to avoid the lethal effect of obesity.
For the proper understanding of the mechanism of obesity and associated diseases in the later stages of life, for having accurate measure to avoid obesity in the old ages, the future research effort should be given to establish an animal model which had comparatively larger life span like human being. In continuation, instead of doing short-term study, it could be recommended to conduct long-term investigation to have a concrete understanding and checklist of safety measures to be taken at different stages of age to avoid the lethal effect of obesity. Moreover, the role of other genes in terms of obesity should be taken under consideration that might unveil a path to overcome the genetic effect of obesity (obesity derived from different genes inherited from ancestors).

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