Streptozotocin에 의해 유도된 당뇨모델에서 구절초(Chrysanthemum zawadskii)의 항당뇨 효과 Anti-diabetic Effects of Chrysanthemum zawadskii on Streptozotocin Induced Diabetes Model원문보기
구절초(Chrysanthemum zawadskii var. latilobum)는 국화과의 다년생 초본으로 선모초(仙母草) 및 야국(野菊) 등으로 불리며, 동아시아 산지와 고원지에서 자생하는 식물로 전통의약에서는 부인병에 활용되어왔으며, 항산화, 항염 등의 생리활성 또한 보고되고 있는 소재임. 따라서 본 연구에서는 오랜 기간 식, 약용 섭취를 통해 안전성 및 효능이 검증된 구절초를 활용하여 혈당 개선을 통한 항당뇨 효능 검증을 위해 다양한 추출 조건별 생리활성 물질(polyphenolic, ...
구절초(Chrysanthemum zawadskii var. latilobum)는 국화과의 다년생 초본으로 선모초(仙母草) 및 야국(野菊) 등으로 불리며, 동아시아 산지와 고원지에서 자생하는 식물로 전통의약에서는 부인병에 활용되어왔으며, 항산화, 항염 등의 생리활성 또한 보고되고 있는 소재임. 따라서 본 연구에서는 오랜 기간 식, 약용 섭취를 통해 안전성 및 효능이 검증된 구절초를 활용하여 혈당 개선을 통한 항당뇨 효능 검증을 위해 다양한 추출 조건별 생리활성 물질(polyphenolic, flavonoid, linarin) 함량을 분석하고 항산화 활성 및 당대사에 미치는 효소 활성 검증을 통해 최적의 추출 조건을 확립하였으며, Streptozotocin (STZ)로 유도된 당뇨 생쥐 모델을 통해 구절초의 혈당 조절 개선 효과 및 췌장 랑게르한스섬의 보호 효과를 확인함. 이는 구절초를 이용한 제품 개발 및 활용범위 확대 등 후속연구의 기반자료로 활용될 수 있을 것으로 사료됨.
구절초(Chrysanthemum zawadskii var. latilobum)는 국화과의 다년생 초본으로 선모초(仙母草) 및 야국(野菊) 등으로 불리며, 동아시아 산지와 고원지에서 자생하는 식물로 전통의약에서는 부인병에 활용되어왔으며, 항산화, 항염 등의 생리활성 또한 보고되고 있는 소재임. 따라서 본 연구에서는 오랜 기간 식, 약용 섭취를 통해 안전성 및 효능이 검증된 구절초를 활용하여 혈당 개선을 통한 항당뇨 효능 검증을 위해 다양한 추출 조건별 생리활성 물질(polyphenolic, flavonoid, linarin) 함량을 분석하고 항산화 활성 및 당대사에 미치는 효소 활성 검증을 통해 최적의 추출 조건을 확립하였으며, Streptozotocin (STZ)로 유도된 당뇨 생쥐 모델을 통해 구절초의 혈당 조절 개선 효과 및 췌장 랑게르한스섬의 보호 효과를 확인함. 이는 구절초를 이용한 제품 개발 및 활용범위 확대 등 후속연구의 기반자료로 활용될 수 있을 것으로 사료됨.
In modern society, metabolic diseases such as diabetes have a high prevalence and act as an underlying disease for various diseases, causing social problems related to public health and are known to be the main cause of adversely affecting the quality of life. Accordingly, research a...
In modern society, metabolic diseases such as diabetes have a high prevalence and act as an underlying disease for various diseases, causing social problems related to public health and are known to be the main cause of adversely affecting the quality of life. Accordingly, research and products for the improvement of diabetes have been mainly developed and used by most of pharmaceutical companies, but consumers are interested in and demand for functional food products using physiologically active ingredients derived from natural materials due to the fear of side effects and rejection of drugs is an increasing trend. As a plant that grows wild in the mountainous and highlands of East Asia, Chrysanthemum zawadskii var. latilobum has been used in traditional medicine for gynecological diseases and it is a perennial herb in the Asteraceae family, called Seonmocho and Wild flowers. Also it is a material that has also been reported to have physiological activities such as anti-oxidation and anti-inflammatory. Therefore, in this study, the content of physiologically active substances (polyphenolic, flavonoid, linarin) by various extraction conditions was analyzed to verify the anti-diabetic efficacy by improving blood glucose by using Chrysanthemum zawadskii var. latilobum, which has been proven for safety and efficacy through food and medicinal intake for a long period of time. The optimal extraction conditions were established through verification of anti-oxidant activity and enzyme activity on glucose metabolism, and the effect of improving blood glucose control of Chrysanthemum zawadskii var. latilobum and protecting the pancreatic islets of Langerhans was confirmed through a streptozotocin (STZ)-induced diabetic mouse model. It is thought that this can be used as a basis for expanding the range of use of Chrysanthemum zawadskii var. latilobum and developing products using it or for follow-up research.
In modern society, metabolic diseases such as diabetes have a high prevalence and act as an underlying disease for various diseases, causing social problems related to public health and are known to be the main cause of adversely affecting the quality of life. Accordingly, research and products for the improvement of diabetes have been mainly developed and used by most of pharmaceutical companies, but consumers are interested in and demand for functional food products using physiologically active ingredients derived from natural materials due to the fear of side effects and rejection of drugs is an increasing trend. As a plant that grows wild in the mountainous and highlands of East Asia, Chrysanthemum zawadskii var. latilobum has been used in traditional medicine for gynecological diseases and it is a perennial herb in the Asteraceae family, called Seonmocho and Wild flowers. Also it is a material that has also been reported to have physiological activities such as anti-oxidation and anti-inflammatory. Therefore, in this study, the content of physiologically active substances (polyphenolic, flavonoid, linarin) by various extraction conditions was analyzed to verify the anti-diabetic efficacy by improving blood glucose by using Chrysanthemum zawadskii var. latilobum, which has been proven for safety and efficacy through food and medicinal intake for a long period of time. The optimal extraction conditions were established through verification of anti-oxidant activity and enzyme activity on glucose metabolism, and the effect of improving blood glucose control of Chrysanthemum zawadskii var. latilobum and protecting the pancreatic islets of Langerhans was confirmed through a streptozotocin (STZ)-induced diabetic mouse model. It is thought that this can be used as a basis for expanding the range of use of Chrysanthemum zawadskii var. latilobum and developing products using it or for follow-up research.
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