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논문 상세정보

초록

50가지 식물자원을 대상으로 혈압상승을 주도하는 효소인 angiotensin converting enzyme의 저해활성을 검색하였다. 그결과 추출물농도 1mg/ml에서 50%이상의 높은 저해활성을 보인 식물은 산뽕나무, 머위, 산부추, 돌나물, 꿀풀, 쇠비름, 마가목, 복분자, 속새, 감초, 창포 등 11종으로 나타났다. 또한 1mg/ml농도에서 목단, 곰취, 도인, 길경, 만형자, 참취, 익모초, 산조인, 가래나무, 석곡, 오갈피, 목향 등 12종은 $40{\sim}49%$의 비교적 높은 ACE 억제활성을 보였다. 1mg/ml에서 $30{\sim}39%$의 억제율을 보인 식물은 백부자, 백출, 세신, 당귀, 인삼, 천궁, 치자 등이었으며 현호색, 행인, 단삼, 백작약, 두충 강활 박하, 진피, 방기, 고본, 구기자, 홍화, 포황, 음양곽, 원지등은 $10{\sim}29%$의 낮은 저해활성을 보였다. 앞으로 ACE 억제활성이 높은 식물자원의 유효성분에 대한 물질확인과 동물모델을 이용한 효능검증에 대하여 더 많은 연구가 있어야 할 것으로 사료된다.

Abstract

Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of medicinal plant extracts on ACE. Fifty medicinal plants were selected and the extracts were prepared by refluxing with 70% methanol. Among the extracts, eleven medicinal plant extracts such as Sedum sarmentosum Bunge, Petasites japonicus(s.et z.) Max, Rubus coreanus, Morus bombycis Koidz, Acorus calamus var. angustatus, Glycyrhiza glabra, Equisetum hyemale, Portulaca oleracea L., Prunella vulgaris var. lilacina Nakai, Sorbus commixta Hedl, Allium thunbergii showed more than 50% inhibitory activities, and Paeonia suffruticosa Andr., lnula helenium, Acanthopanax senticosus Harms, Dendrobium moniliforme, Juglans mandshurica, Zizyphus jujuba, Leonurus artemisia, Aster scaber Thunb, Vitex rotundifolia, Platycodon grandiflorum, Prunus persica, Ligularia fischeri showed $40{\sim}49%$ inhibitory activities. Therefore these extracts which contain high ACE inhibitory activities may be useful as antihypertension agents and to the treatment of hypertension.

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  2. Lee, Yun-Mi ; Kang, Dae-Gill ; Kim, Myung-Gyu ; Jang, Ji-Yeon ; Lee, Ho-Sub 2005. "Isolation of Angiotensin Converting Enzyme Inhibitory Component from the Seeds of Xanthium strumarium" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 19(1): 119~123 
  3. Shon, Mi-Yae ; Nam, Sang-Hae 2007. "Inhibitory Effects of Eucommia ulmoides Extract on Angiotensin Converting Enzyme" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 36(12): 1511~1516 
  4. Shon, Mi-Yae ; Nam, Sang-Hae 2007. "Effect of Eucommia ulmoides Extracts on Allergic Contact Dermatitis and Oxidative Damage Induced by Repeat Elicitation of DNCB" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 36(12): 1517~1522 
  5. Jeong, Hyun-Jin ; Kim, Sun-A ; Kwon, Joong-Ho ; Kim, Hyun-Ku 2008. "Physiological Activities of Gardeniae Fructus Extracts by Microwave-Assisted Extraction as Affected by Solvents" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 37(3): 282~287 
  6. Lee, Hye-Won ; Choi, Ji-Hyun ; Park, So-Young ; Choo, Byung-Kil ; Chun, Jin-Mi ; Lee, A-Yeong ; Kim, Ho-Kyoung 2008. "Constituents Comparison of Components in Native and Cultivated Species of Angelica tenuissima Nakai" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 16(3): 168~172 
  7. Chang, Sang-Keun ; Kim, Jun-Ho ; Oh, Hae-Sook 2008. "The Development of Functional Cold Buckwheat Noodles Using Biological Activities of Hot Water Extracts of Ligularia fischeri and Angelica gigas Nakai" 韓國食生活文化學會誌 = Journal of the Korean Society of Food Culture, 23(4): 479~488 
  8. Lee, Yang-Suk ; Choi, Bok-Dong ; Joo, Eun-Young ; Shin, Seung-Ryeul ; Kim, Nam-Woo 2009. "Antioxidative Activities and Tyrosinase Inhibition Ability in Various Extracts of the Vitex rotundifolia Seeds" 한국식품저장유통학회지 = Korean journal of food preservation, 16(1): 101~108 
  9. Ban, Chang-Kye ; Lee, Min-Ja ; Lee, Hye-Sook ; Jung, Hyun-Jung ; Kim, Hyuck ; Kim, Jai-Eun ; Park, Sun-Dong ; Park, Won-Hwan 2009. "Screening of Antioxidative, Anti-thrombotic and Anti-atherosclerotic Effects of Moutan Root Bark Extracts" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 23(1): 135~143 
  10. Surh, Jeong-Hee ; Kim, Jong-Ok ; Kim, Mi-Hyun ; Lee, Jae-Choel ; Yang, Hee-Wan ; Lee, Byung-Yong ; Kim, Mi-Young ; Yun, Sun-Ju ; Jeong, Hye-Ryeon 2009. "Nutritional Properties, as Food Resources for Menu Development, of Cubed Snailfish, Shaggy Sea Raven, and Two Kinds of Wild Vegetables that are Staple Products in Samcheok" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 25(6): 690~702 
  11. 2009. "" Journal of food science and nutrition, 14(2): 168~171 
  12. Joo, Ok-Soo ; Nam, Sang-Hae 2009. "ACE Inhibitory Lignan Glycosides Isolated from Eucommia ulmoides Oliver" 생명과학회지 = Journal of life science, 19(6): 698~704 
  13. Park, Dong-Sik ; Park, Mi-Young ; Chon, Sang-Min ; Lee, Jin-Young ; Lee, Young-Min ; Jang, Hwan-Hee ; Hwang, Kyung-A ; Kim, Jae-Hyun 2011. "Antioxidant Activity of Different Solvent Fractions from Prunella vulgaris var. lilacina" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(6): 484~490 
  14. Jo, Bun-Sung ; Cho, Young-Je 2012. "Biological Activity of Extracts from Acanthopanax sessiliflorum Fruit" 한국식품저장유통학회지 = Korean journal of food preservation, 19(4): 586~593 
  15. Lee, Chan-Jung ; Cheong, Jong-Chun ; Jhune, Chang-Sung ; Moon, Ji-Won ; Kong, Won-Sik ; Suh, Jang-Sun ; Park, Gi-Chun ; Shin, Yu-Su ; Lee, Jeong-Hoon 2013. "Yields of oyster mushroom(Pleurotus ostreatus) on addition rate of Juglans mandshurica sawdust" 한국버섯학회지 = Journal of mushroom science and production, 11(4): 219~225 
  16. Seo, Ji-Hyung ; Jeong, Yong-Jin 2013. "Physiological properties of Leonurus sibiricus water extracts with different extraction condition" 한국식품저장유통학회지 = Korean journal of food preservation, 20(4): 592~596 
  17. Lee, Soo-Yeon ; Kim, Jeung-Hoan ; Park, Jung-Mi ; Lee, In-Chul ; Lee, Jin-Young 2014. "Antioxidant activity and inhibition activity against α-amylase and α-glucosidase of Smilax China L." 한국식품저장유통학회지 = Korean journal of food preservation, 21(2): 254~263 
  18. Jung, Ho Kyung ; Jang, Ji Hun ; Ko, Jae Hyung ; Kang, Byoung Man ; Yeo, Jun Hwan ; Cho, Jung Hee ; Cho, Hyun Woo ; Bean, Chul Gu ; Kim, Seong Cheol ; Jung, Won Seok 2014. "Whitening and Anti-wrinkle Effects of Korean Native Dendrobium moniliforme Methanol Extract" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 22(5): 331~338 
  19. Kim, Tae-Yeon ; Bak, Jong-Phil 2015. "Antioxidant and Protective Effects of Palmul-tang on Ultraviolet B (UVB)-induced Damage in Human Keratinocytes" 대한예방한의학회지 = Journal of Society of Preventive Korean Medicine, 19(3): 141~154 

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