$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

내분비계 장애물질의 개요와 검색법의 고찰
Overall Review on endocrine disruptors 원문보기

농약과학회지 = The Korean journal of pesticide science, v.6 no.3, 2002년, pp.135 - 156  

류재천 (한국과학기술연구원 생체대사연구센터 독성연구실)

초록
AI-Helper 아이콘AI-Helper

내분비계 장애물질이 환경호르몬이란 용어로 우리들의 실생활에 사용되는 용기 등을 통해 여러 가지 영향을 미치고 있다. 수많은 화학물질들 중에서 환경호르몬은 어떠한 종류의 화학물질이며, 언제 알려지게 되었고, 어떻게 분류되었으며, 이러한 환경호르몬성을 갖는 물질들의 환경호르몬성은 어떠한 연구기법에 의해 검색되는지와 현재까지의 사용실태와 문제점 및 국내외 관련 동향 등을 고찰하여 보았다.

주제어

참고문헌 (73)

  1. A Study on Hormone-like (Hormone-mimic) Effects of Exogenous substances. (1997) Japan Chemical Industry Association and Japan Chemical Industry Ecology-Toxicology and Information Center 

  2. Andersen H.R., Andersson A.M., Arnold S.F., Autrup H., Barfoed M., Beresford N.A, Bjerregaard P., Christiansen L.B., Gissel B., Hummel R., Jorgensen E.B., Korsgaard B., Le Guevel R., Leffers H , McLachlan J., Moller A, Nielsen J.B., Olea N., Oles-Karasko A, Pakdel F., Pedersen K.L., Perez P., Skakkeboek N.E., Sonnenschein c., Soto Ana M., Sumpter JP., Thorpe S.M., Grandjean P. (1999) Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals. Environ. Health Persp. 107(Suppl 1):89-108 

  3. Appraisal of Test Methods for Sex-Hormone disrupting Chemicals capable of affecting the reproductive process; prepared by the MRC. Institute for Environmental and Health for the UK Department of Environment, Transport and Regions, (1998) 

  4. Arcaro K.F., Yang Y. Vakharia D.D., Gierthy J.F. (2000) Toxaphene is antiestrogenic in a human breast-cancer cell assay. Toxicology & Environ. Health Part A 59(3):197-210 

  5. Arcaro K.F., Yang Y. Vakharia D.D., Gierthy J.F. (2000) Toxaphene is antiestrogenic in a human breast-cancer cell assay. Journal of Toxicology & Environ. Health Part A. 59(3):197-210 

  6. Ashby J., Lefevre P.A, Odum J., Tinwell H, Kennedy S.J., Beresford N.A., Sumpter J.P., (1997) Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents. Regul. Toxicol. Pharmacol. 26(1 Pt 1):96-101 

  7. Barnes S. Kim H Darley-Usmar V. Patel R. Xu J. Boersma B. Luo M. (2000) Beyond ER alpha and ER beta: Estrogen receptor binding is only part of the isoflavone story. Journal of Nutrition. 130(3):6565- 6575 

  8. Beekman J.M., Allan G.F., Tsai S.Y., Tsai M.J., O'Malley B.W. (1993) Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol. Endocrinol. 7:1266 -1274 

  9. Carlos Sonnenschein and Ana M. Soto (1998) An updated review of environmental estrogen and androgen mimics and antagonists. J. Steroid Biochem. Molec. BioI. 65(1):143 -150 

  10. Co-ordination of Endocrine Disrupters Assessment Activities, http://www.oecd.org/ehs/endocrin.htm 

  11. Colom., T. (1995) Environmental estrogens; Health implications for Humans and wildlife, Environ. Health Persp.,103(Suppl 7):135-136 

  12. Davis, D.L. and Bradlow, H.L. (1995) can Environmental Estrogens Cause Breast Cancer, Sci. Amer. pp.166-172 

  13. Endocrine disruptors listed from our stolen future and other references, http://www.nihs.go.jp/hse/environ/sdsubs $_{}$ stancesnew.html 

  14. Endocrine disruptors research Initiative, http://www.epa.gov/ endocrine 

  15. Environmental Estrogens & other hormones, http://www.tmc.tulane.edu/ ecme/ eehome/ 

  16. Environmental Health Information Service, http://ehis.niehs.nih.gov/ 

  17. Environmental Oestrogens: Consequences for human health and wildlife. Assessment AI. MRC Institute for Environment and Health, University of Leicester (1995) 

  18. EPA: EDSTAC (1998) Draft report, June 12 

  19. European Workshop on the Impact of Endocrine Disrupters on Human Health and Wildlife. Report of Proceedings. December 2-4, (1996) Weybridge, UK,P128 

  20. Fox, G.A, Gilman, A.P., Peakall, D.B., Anderka, FW. (1978) Behavioural Abnormalities on Nesting Lake Ontario GulIs. J. Wil이. Manage. 43(3):477-483 

  21. Fry, D.M. (1995) Reproductive effects in birds exposured to pesticides and industrial chemicals, Environ. Health Persp. 103(Suppl. 7):165-171 

  22. Gaido, K. W., Leonard, L. S., Lovell, S., Gould, J. C., Babai, D., Portier, C. J., and Mcdonnell, D. P. (1997) Evaluation of chemicals with endocrine modulating activity in a Yeast-Based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol. 143:205-212 

  23. Garrett S.D., Lee H.A, Morgan M.R.A (1999) A nonisotopic estrogen receptor based assay to detect estrogenic compounds. Nature. Biotechnology (12):1219 -1222 

  24. Gilbertson, M., et al., (1991) Great Lakes embryo mortality, edema, and deformities syndrome in colonial fish-eating birds: similarity to chickedema disease. J. Toxicol. Environ. Health 33:455-520 

  25. Grainger D,J., Metcalfe J.C. (1996) Tamoxifen : teaching an old drug new tricks. Nat. Med. 2:381-385 

  26. Green S, Chambon P. (1991) The estrogen receptor: from perception to mechanism. In : Nuclear hormone receptors : molecular mechanisms, cellular functions, clinical abnormalities(Parker MG, ed). London: Academic Press. pp.15-38 

  27. Guillette, L.J., Gross, T.S., Masson, G.R., Matter, J.M., Percival, H.F., and Woodward, A R. (1994) Developmental abnormalities of the gonad and abnonnal sex homone concentrations in juvenile alligators from contaminated and control lakes in Florida, Environ. Health Persp. 102:680-688 

  28. Harris, C. A, Henttu, P., Parker, M. G., and Sumpter, J. P. (1997) The estrogenic activity of phthalate esters In vitro, Environ. Health. Perspect. 105(8):802- 811 

  29. Hertz, R. (1985) The estrogen problem: retrospect and prospect. In Estrogens in the Environment. II. Influences on Development, ed. J.A Mclachlam. Elsevier Science B.V., Amsterdam. pp.1-11 

  30. Hutz RJ. Wimpee BAB. Dasmahapatra A Weber DN. Heimler I. Chaffin CL. (1999) Differential modulation by aromatic hydrocarbon receptor agonist of circulating estradiol-17 beta and estrogen-receptor DNA-binding capability in female rainbow trout (Oncorhynchus mykiss). Zoological Science. 16(1):161-166 

  31. Introduction to hormone disrupting chemicals, http://website.lineone.net/ -mwarhurst/ 

  32. Jordan V.C. (1994) Molecular mechanisms of antiestrogen action in breast cancer. Breast Cancer Res Treat 31:41-52 

  33. Kartin, P.M., Horwitz, K.B., Ryan, D.S., McGuire, W.L. (1978) Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103:1860 -1867 

  34. Kelley S.T., Thackray V.G. (1999) Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms. J. Mol. Evolution 49(5):609-614 

  35. Korach K.S. and Mclachlan J.A. (1995) Techniques for detection of estrogenicity. Environ. Health Persp. 103(Suppl 7):5-8 

  36. Krishnan, A, et aI. (1991) Bisphenol-A:An estrogenic substance is released from polycarbonate flasks during auto claving., Endocrinology. 132(8):2279-2286 

  37. Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J.A. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 138(3):863-870 

  38. Kuiper G.G., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J.A. (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc . Natl. Acad. Sci USA. 93(12):5925 - 5930 

  39. Landel C.C., Kushner P.J., Greene G. (1995) Estrogen receptor accessory proteins: effects on receptor-DNA interactions. Environ Health Persp. 103(Suppl 7):23-28 

  40. Lee, H-S., et al., (2002) Empolyment of the human estrogen receptor B1igand-binding domain and co-activator SRCl nuclear receptor-binding domain for the contruction of a yeast two-hybrid detection system for endocrine disrupters. J. Biochern. 131:399-405 

  41. Long X.H., Steinmetz R., Ben-Jonathan N. Caperell-Grant A. Young P.C.M., Nephew K.P., Bigsby R.M. (2000) Strain differences in vaginal responses to the xenoestrogen bisphenol A. Environ. Health Persp. 108(3):243-247 

  42. McDonnell, D.P., et aI. (1991) High level expression of biologically active estrogen receptor in saccharomyces cerevisiae. J. Steroid Biochem. Mol. Biol. 39:291-297 

  43. Metzger, D., et al. (1988) The human oestrogen receptor function in yeast. Nature 334:31-36 

  44. NIEHS/NTP Research and Interagency Activities on Endocrine Disrupting Chemicals, NIH, USA 

  45. Odum J., Lefevra PA, Tittensor S., Paton D., Routledge E.J., Beresford NA, Sumpter J.P., Ashby J., The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul. Toxieol. Pharmacol. (1997) 25(2):176-88 

  46. Paech K., Webb P., Kuiper G.G., Nilsson S., Gustafsson J., Kushner P.J., Scanlan T.S. (1997) Differential ligand activation of estrogen receptors ER-alpha and ER-beta at AP 1 sites. Science 277:1508-10 

  47. Palmer, B.D. and Palmer, S.K. (1995) Vitellogenm induction by xenobiotic estrogens in the red-eared turtle and african clawed frog, Environ. Health Persp. 103(Suppl 4):19-25 

  48. Parker M.G., Arbuckle N., Dauvois, Danielian P., White R. (1993) Structure and funtion of the estrogen receptor. Ann NY Acad Sci 684:119-126 

  49. Pedraza V. et al. (1991) The E-screen assay: A comparison of different MCF-7 cell stocks, Environ. Health Persp. p.103, pp.844-850 

  50. Perez P., Pulgar R., Olea-Serrano F., Villalobos M. Rivas A., Metzler M., Pedraza V. and Olea N. (1998) The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups. Environ. Health Persp. 106(3):167-74 

  51. Reel J.R., Lamb I.V.C, Neal B.H. (1996) Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fundam. Appl Toxieol 34(2):288-305 

  52. Rehmann K. Schramm K.W. Kettrup A. Chemosphere (1999) Applicability of a yeast oestrogen screen for the detection of oestrogenlike activities in environmental samples. 38(14):3303-3312 

  53. Routledge, E. J. and J.P. Sumpter (1997) Structural feature of alkylphenolic chemicals associated with estrogenic activity. J. BioI. Chem. 272:3280-3288 

  54. Routledge, E. J., and J.P. Sumpter (1996) Estrogenic activity of surfactant and some of their degradation products assessed using a recombinant yeast screen, Environ. Toxicol. Chem. 15(3):241-248 

  55. Schultz, T. W., Seward, J. R., and Sinks G. D. (2000) Estrogenicity of benzophenes evaluated with a recombinant yeast assay: comparison of experimental and rules-based predicted activity. Environ. Toxicol. Chem. 19(2):301-304 

  56. Smith D.F., Toft D.O. (1993) Steroid receptors and their associated proteins. Mol. Endocrinol 7:4-11 

  57. Smithsonian Institution (1997) International Workshop on endocrine disruptors, Workshop report, Washington D.C. pp.23-24, USA. 

  58. Soto Ana M. and Sonnenschein C. (1984) Mechanism of estrogen action on cellular proliferation: evidence for indirect and negative control on cloned breast tumor cells. Biochem Biophys Res. Commun. 16;122(3):1097-1103 

  59. Soto Ana M. and Sonnenschein C. (1985) The role of estrogens on the proliferation of human breast tumor cells (MCF-7). J Steroid Biochem.23(1):87-94 

  60. Soto Ana M., Fernandez M.F., Luizzi M.F., Oles Karasko A.S. and Sonnenschein C. (1997) Developing a marker of expos따e to xenoestrogen mixtures in human serum. Environ. Health Persp. 105(Suppl 3):647-654 

  61. Soto, Ana M., Justica, H., Wray, J. and Sonnenschein, C. (1991) p-Nonylphenol : A estrogenic xenobiotic released from 'Modified' polystyrene, Environ. Health Persp. 92:167-173 

  62. Soto, Ana. M., Sonnenschein, C., Chung K. L., Fernandez, M. F., Olea, N., and Serrano, F. O. (1995) The E-SCREEN assay as a tool to identify estrogen: An update on estrogenic environmental ppllutants, Environ. Health. Persp. pp.103-122 

  63. Stancel G.M., Boettger-Tong H.L., Chiappetta C, Hyder S.M., Kirkland J.L., Murthy L., Loose-Mitchell D.S. (1995) Toxicity of endogenous and environmental estrogens: what is the role of elemental interactions. Environ. Health Persp. 10(Suppl 7):29-33 

  64. Thomas J.A. and H.D. Colby (1997) Endocrine Toxicology, Ed;2nd Ed., Taylor & Francis 

  65. Tsai M.J. and O’Malley B.W. (1994) Molecular mechanism of action of steroid/thyroid receptor superfamily members. Ann. Rev. Biochem. 63:451-486 

  66. U.S. EPA. (1997) Special report on Environmental Endocrine Disruption: An Effects Assessment and Analysis. Office of Research and Development, EPA/630/R-96/012, Washington D.C. 

  67. Vinggaard A.M., Breinholt V. and Larsen J.C. (1999) Screening, of selected pesticides for oestrogen receptor activation in vitro. Food Additives & Contaminants 16(12):533-542 

  68. Welcome to EPA's Endocrine Disruptor Screening and Testing Advisory Committee Home, http://www.epa.gov/ opptintr/opptendo 

  69. Workshop on the Status of Regulatory and Research Activities on Endocrine Disrupting Chemicals, July 12, Holiday Inn Seoul, Korea, (1999) 

  70. Wright, A P. H., Carlstedt-Duke, J. and Gustafsson, J. A (1990) Ligand-specific transactivation of gene expression by a derivative of the human glucocorticoid receptor expressed in yeast. J. BioI. Chem. 265:14763-14769 

  71. Yadetie F. Arokwe A Goksoyr A Male R.Induction of hepatic estrogen receptor in juvenile Atlantic salmon in vivo by the environmental estrogen, 4-nonylphenol. Science of the Total Environment. 233(1-3):201-210, 1999 

  72. Zava, D. T., and McGurie, W. L. (1978) Androgen activation through estrogen receptor in a human breast cancer cell line. Endocrinology 103:624-631 

  73. 내분비계장애물질 중장기 연구사업계획 (38000-67610-57-9961) 환경부, (1999) 

저자의 다른 논문 :

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로