[논문]Hypocholesterolemic Property of Yucca schidigera and Quillaja saponaria Extracts in Human Body

Kim, Sang-Woo; Park, Sang-Kyu; Kang, Sung-Il; Kang, Han-Chul; Oh, Han-Jin; Bae, Chul-Young; Bae, Dong-Ho

doi:10.1007/bf02994756

Hypocholesterolemic Property of Yucca schidigera and Quillaja saponaria Extracts in Human Body 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.26 no.12, 2003년, pp.1042 - 1046

Kim, Sang-Woo (Division of Endocrinology & Metabolism, Department of Medicine, Miz Medi Hospital) , Park, Sang-Kyu (Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology) , Kang, Sung-Il (Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology) , Kang, Han-Chul (Research Center of Celltechs Co.) , Oh, Han-Jin (Department of Family Medicine, Samsung Cheil General Hospital, Sungkyunkwan University of Medicine) , Bae, Chul-Young (Department of Family Medicine, Bundang Cha General Hospital, Phochon Jungmoon University of Medicine) , Bae, Dong-Ho (Department of Applied Biology & Chemistry, Konkuk University)

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This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous qullaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholestrolemic patients with enhancement in gastrointestinal symptoms of patients.

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Therefore, this study was undertaken to observe the effects of Yucca schidigera and Quil/aja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to produce a nutraceutical ingredient economically as a preliminary study for the farther purpose of development of a new cholesterol-lowering drug without severe side effects.

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mostly triterpenoidal saponins. A Waters model 501 chromatograph equipped with a Waters model 441 detector and a column (WATO 27324, 3.9x300 mm) was used. The sample loop was 20 μL.
Eighty-six patients were included in the 시inical tests at Miz Me예 Hospital in Seoul, Korea. These were divided into two groups.
Eighty-six patients, having more than 220 mg/dL triglyceride level in blood, were given either the YQ2 or placebo in a random selection double-blind study at Miz Medi Hospital in SeouI, Korea. Before the test, the patients who had diseases or medications affecting to lipid metabolism or gastrointestinal function within recent 3 months, were excluded in this study.
Yucca schidigera and Quillaja saponaria used in this study were harvested in Mexico and Chile, respectively, and processed to produce the extracts by Celltechs Corporation in Korea. The trunk of the yucca were mechanically ground, squeezed in a press to produce yt/cca juice, and then, partially concentrated by evaporation to produce yt/cca extracts.

이론/모형

design. Data were analyzed using the general linear model procedures of SAS (1992) to determine differences between treatment means. Pair-wise comparison of all treatment means was performed using the Least Significant Difference (LSD) procedure with significance defined at P<0.

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Hypocholesterolemic Property of Yucca schidigera and Quillaja saponaria Extracts in Human Body 원문보기

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Hypocholesterolemic Property of Yucca schidigera and Quillaja saponaria Extracts in Human Body 원문보기

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