[논문]Comparing the Performance of One-column Process and Four-zone Simulated Moving Bed by Computer Simulation

Kim Young Sik; Lee Chong Ho; Wankat Phillip C.; Koon Yoon Mo

doi:10.1007/bf02933058

Comparing the Performance of One-column Process and Four-zone Simulated Moving Bed by Computer Simulation 원문보기

Biotechnology and bioprocess engineering : Bbe, v.9 no.5, 2004년, pp.362 - 368

Kim Young Sik (Department of Biological Engineering, ERC for Advanced Bioseparation Technology, Inha University) , Lee Chong Ho (Department of Biological Engineering, ERC for Advanced Bioseparation Technology, Inha University) , Wankat Phillip C. (School of Chemical Engineering, Purdue University) , Koon Yoon Mo (Department of Biological Engineering, ERC for Advanced Bioseparation Technology, Inha University)

Abstract ▼ AI-Helper

A new one-column chromatography process, analogous to a four-zone simulated moving bed (SMB), was presented. The basic principle of the process was identical to that of a four-zone SMB. The process consisted of one chromatographic column and four tanks, instead of the four columns in the four-zone SMB (1-1-1-1), and has been used for the separation of two amino acids, phenylalanine and tryptophan, using an ion exchange resin. The operating parameters for the one-column process and four-zone SMB were obtained from equilibrium theory. Computer simulations were used to compare the performances of the new one column process to that of the general four-zone SMB, using Aspen $Chromatography^{TM}$ v 11.1. The differences between the one-column and SMB processes in terms of the purities and yields of phenylalanine and tryptophan were less than 4 and about $6\%$, respectively. The lower purities of the one-column process were due to the loss of the developed concentration profiles in the column when the liquid was stored in tanks. The one-column process gave great flexibility, and would be useful for reconstructing an existing conventional chromatography process to one of a SMB.

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가설 설정

A four-zone TMB system is presented in Fig. 1. The feed is continuously supplied to the center of the column, with the mobile phase flowing upward, and the solid phase flowing downward. The lower affinity solute (B) moves in the direction of the mobile phase, while the higher affinity solute (A) moves in the counter direction; A is withdrawn at the extract port and B at the raffinate port, as illustrated in Fig.

제안 방법

The main drawback is the expensive fixed costs and complex process operation. These disadvantages are overcome by studying different classical four-zone SMB schemes, applying modified operation and optimization strategies for the SMB process, and developing computer simulations. Many different classical four-zone SMB schemes and modified operation strategies have been studied.

대상 데이터

4. The system consists of two solenoid valves and two time controllers for flow path control, and four tanks for effluent storage. In the process, a complete cycle consists of four switching periods.

이론/모형

All of the columns in a SMB process should be identically packed, otherwise this can cause errors. The operating conditions were obtained using equilibrium theory, as suming a negligible mass transfer resistance. The flow rate ratio selection was achieved using the “triangle theory” developed by Morbidelli et al.
The triangle theory, developed by Morbidelli's group [16], was used, which suggests operating conditions that lead to a complete separation of the products, based on the relative flow rates of the fluid and solid phases, The designs of the operating conditions of the SMB units have been developed under ideal conditions, where the mass transfer resistance and axial dispersion are neglected. The optimum operating conditions for the SMB and one-column processes in this study were obtained using the triangle theory. The separation performance was controlled by the flow rate ratios between each zone of the SMB unit.

참고문헌 (19)

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상세보기
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원문보기 상세보기
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상세보기
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상세보기
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원문 URL 링크

DOI : 10.1007/BF02933058 [무료]
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