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논문 상세정보

화상 및 창상 치료용 외용제제 개발에 대한 기초 연구

Studies on the Wound Healing by the PVA-soft hydrogel

약학회지 = Yakhak hoeji v.48 no.1 , 2004년, pp.55 - 59  
Abstract

A PVA-soft hydrogel, which is a semi-solid form in container, whereas after applying on the skin, it formed a thin layer within a few minutes. In this study, we prepared a novel type PVA-soft hydrogel containing 6-methyluracil as active drug, and the therapeutic value was characterized. To evaluate the therapeutic value of the PVA-soft hydrogel containing drug, various animal models, thermal burn model, incision & excision wound rat model were used. We also measured the wound size and breaking strength to calculate the wound healing extent after single or multiple administration. The wound size of soft hydrogel treated group decreased rapidly than that of control group after multiple dosing in excision wound model. And, the breaking strength of the soft hydrogel treated group was greater than that of control group in incision wound model.

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이 논문을 인용한 문헌 (3)

  1. Min, Dong-Hoon ; Kim, Dae-Keun ; Lim, Jong-Pil ; Yang, Jae-Heon 2005. "Transdermal Drug Delivery & Therapeutic Effect of the Preparations of Lithospermi Radix and Gardeniae Fructus Extracts on the Burn & Wound Healing" 藥劑學會誌 = Journal of Korean pharmaceutical sciences, 35(4): 255~263 
  2. Oh, Seung-Seok ; Kim, Chul-Jun ; Kim, Hee-Sook ; Shin, Young-Hee 2009. "Efficacy of Hydrogel Patch in Wound Rat Model" 藥劑學會誌 = Journal of Korean pharmaceutical sciences, 39(1): 55~58 
  3. Song, Beom-Yong ; Lee, Chang-Hyun 2009. "Effects of the Acupuncture or Pharmacopunture Treatment for the Histologic and Morphologic Recovery on the Mouse with the Burn Skin" 大韓鍼灸學會誌= The journal of Korean Acupuncture & Moxibustion Society, 26(3): 81~92 

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