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카드뮴이 마우스 뇌에서 아연의 항상성에 관여하는 유전자발현에 미치는 영향
Cadmium Altered Gene Expression Related to Zinc Homeostasis in the Mouse Brain 원문보기

환경독성학회지 = Journal of environmental toxicology, v.19 no.4 = no.47, 2004년, pp.389 - 399  

박종안 (순천향대학교 환경보건학과) ,  여은영 (순천향대학교 환경보건학과) ,  남상훈 (순천향대학교 환경보건학과) ,  장봉기 (순천향대학교 환경보건학과) ,  이종화 (순천향대학교 환경보건학과) ,  김완종 (순천향대학교 생물학과)

Abstract AI-Helper 아이콘AI-Helper

Metallothionein (MT), a small protein molecule which can bind or release metal ions, is involved in the regulation of cellular metal homeostasis. This study was investigated the accumulation of cadmium in blood, tissue (liver, kidney and brain), and the effect of cadmium on several key genes (MT-I, ...

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참고문헌 (59)

  1. 김남송. 전처치 기간에 따른 흰쥐의 조직내 카드뮴 및 metallothionein 생성에 관한 연구. Korean J Toxicol 1997; 13(1-2): 103-110 

  2. 김판기. 카드뮴이 랫드에 미치는 독성학적 변화에 관한 연구. 용인대학교 논문집 1997; 13: 507-510 

  3. 박종안, 오혜정, 이종화. 흑연로 원자흡수분광법에 의한 혈액 중 카드뮴 정량 분석. 한국산업위생학회지 1996; 6(2): 301-312 

  4. 이순재. 급성 카드뮴 중독 흰쥐 간조직에서의 유리기 생성계의 활성화와 조직손상. 대구효성카톨릭대학교 석사학위논문집 1998; 58: 240-242 

  5. 임순혁. Cadmium 투여에 의한 흰쥐의 간, 신장 및 혈액에서의 축적에 관한 연구. 청주대학교 석사학위논문.; 1992. pp. 5-6 

  6. Abuja PM and Albertini R. Methods for monitoring Oxida-tive stress, lipid peroxidation and oxidation resistance of lipoproteins. Clin Chim Acta 2001; 306(1-2): 1-7 

  7. Adams JD Jr. Klaidman LK, Chang ML and Yang J. Brain oxidative stress-analytical chemistry and thermody-namics of glutathione and NADPH. Curr Top Med Chem 2001; 1(6): 473-482 

  8. Angelo A Valois and William S Webster. The choroid plexus as a target site for cadmium toxicity following chronic exposure in the adult mouse. An ultrastructural study. Toxicology 1989; 55(1-2): 193-205 

  9. Arlt S, Kontush A, Muller-Thomsen T and Beisiegel U. Lipid peroxidation as a common pathomechanism in Cor-onary heart disease and Alzheimer's disease. Gerontol Geriatr 2001; 34(6): 461-465 

  10. Arranz MA, Perez MI, Saiz-VadiIlo MC, Basagoiti I, Katarneh SM, Ribas B and Cadorniaa R. Pharmaco-kinetics of cadmium-109 in blood and brain structure of the rat. Rev Esp 1984; 40(3): 365-370 

  11. Arvidson B and Tjalve H. Distribution of 109Cd in the nervous system of rats after intravenous injection. Acta Neuropathol(Berl) 1986; 69(1-2): 111-116 

  12. Atsushi Takeda, Sachiyo Takefuta, Hiromi Ijiro, Shoji Okada and Naoto Oku. 109Cd transport in rat brain. Brain Research Bulletin 1999; 49(6): 453-457 

  13. Berg JW and Burbank F. Correlation between carcinogenic trace metals in water supplies and cancer mortality. Ann N.Y Acad Sci.; 1972. pp. 249-262 

  14. Cantilena LR and Klaassen CD. Comparison of the effecti-veness of several chelators after single administration on the toxicity, distribution and excretion of cadmium. Toxicol Appl Pharmacol 1981; 58: 452-460 

  15. Choudhuri S, McKim JM Jr and Klaassen CD. Differential expression of the metallothionein gene in liver and brain of mice and rats. Toxicol appl Pharmacol 1993; 119: 1-10 

  16. Clausen J and Rastogi SC. Heavy metal pollution among autoworkers, lead. Bri J Ind med 1977; 34: 208-215 

  17. Coyle P, Philcox JC, Carey LC and Rofe AM. Metallothionein: The multipurpose protein. CMLS Cell Mol Life Sci 2002; 59: 627-647 

  18. Cuthbert OS. Metallothionein in human disease. Cellular and Molecular Biology 2000; 46(2): 465-488 

  19. Deaven LL and Campbell EW. Factors affecting the induc-tion of chromosomal aberrations by cadmium in Chinese hamster cells. Cytogenet Cell Genet 1980; 26: 251-260 

  20. Dudley RE, Svovoda DJ and Klaassen CD. Acute exposure to cadmium causes severe liver injury in rats. Toxicol Appl Pharmacol 1982; 65: 302-313 

  21. Evans J and Hastings L. Accumulation of Cd (II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal. Fundam Appl Toxicol Aug 1992; 19(2): 275-278 

  22. Faeder EJ, Chanet SQ and King LC. Biochemical and uItras-tructural changes in livers of cadmium treated rats. Toxi-col Appl Pharmacol 1977; 39: 473-483 

  23. Figueiredo-Pereira ME and Cohen G. The ubiquitin/ Proteasome pathway: friend or foe in zinc-, cadmium-, and $H_2O_2$ -induced neuronal oxidative stress. Mol Biol Rep 1999; 26(1-2): 65-69 

  24. Glabe C. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. Mol Neurosci 2001; 17(2): 137-145 

  25. Goyer RA. Toxic effects of metals. In: Klassen CD, Amdur MO and Doull J (eds.), Casarett and Doull's Toxicology., 5th Ed., Macmillan Publishing Co., New york.; 1996. pp. 699-702 

  26. Grundman M. Vitamin E and Alzheimer disease: The basis for additional clinical trials. Clin Nutr 2000; 71(2): 630-636 

  27. Hammond PB and Foulkes EC. Metal ion toxicity in man and animals, In: Siegel, H.(ed.), Metal Ions in Biological Systems. Marcel Dekker, New York 1994; 20: 177-182 

  28. K $\"a$ gi JHR and Schaffer A. Biochemistry of metallothionein. Biochemistry 1988; 27: 8509-8515 

  29. Kanski J, Varadarajan S, Aksenova M and Butterfield DA. Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide l-42-associated oxidative stress and neurotoxicity. Biochim Biophys Acta 2002; 1586 (2): 190-198 

  30. Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C and Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neuro-chem Res 2001; 26(4): 353-361 

  31. Kazantizis G. Renal tubular disfunction and abnormalities of calcium metabolism in cadmium workers. Environ Health Perspect 1979; 28: 155 

  32. Keen CL and Hurley LS. Zinc and reproduction: Effects of deficiency on fetal and postnatal development, in Zinc and Human Biology. Springer-Verlag London.; 1989. pp. 183-200 

  33. Kolonel L and Winkelstein W Jr. Cadmium and prostatic carcinoma. Lancet 1977; 2: 566-567 

  34. Kumar R, Agarwal A and Seth PK. Oxidative stress-medi-ated neurotoxicity of cadmium. Toxicol Letters 1996; 89: 65-69 

  35. Langmade SJ, Ravindra R, Daniels PJ and Andrews GK The transcription factor MTF-l mediates metal regulation of the mouse ZnTl gene. J Biol Chem 2000; 275: 34803-34809 

  36. Lui E, Fisman M, Woung C and Diaz F. Metals and the liver in Alzheimer's disease. An investigation of hepatic zinc, copper, cadmium, and metallothionein. Am Geriatr Soc 1990; 38(6): 633-639 

  37. Malcolm D. Cadmium as a carcinogen, In: Cadmium toxi-city. MennearJH.; 1979. pp. 173-180 

  38. Math PC and Gordon JL. Zinc metabolism in the brain relevance to human neurodegenerative disorders. Neuro-biology of Disease 1997; 4: 137-169 

  39. McMahon RJ and Cousins RJ. Regulation of the zinc trans-porter ZnT-1 by dietary zinc. Proc Natl Acad Sci 1998; 95: 4841-4846 

  40. O'Riordan ML, Hughes EG and Evans HJ. Chromosome studies on blood lymphocytes of men occupationally exp-osed to cadmium. Mutat Res 1978, 58: 305-311 

  41. Palmitier RD, Findley SD, Whitmore TE and Durnam DM. MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci 1992; 89: 6333-6337 

  42. Panayi Ae, Spyrou NM, Iversen BS, White MA and Part P. Determination of cadmium and zinc in Alzheimer's brain tissue using inductively coupled plasma mass Spectrometry. Neurol Sci 2002; 195(1): 1-10 

  43. Pitchumoni SS, Doraiswamy PM. Current status of antioxi-dant therapy for Alzheimer's Disease. Am Geriatr Soc 1998; 46 (12): 1566-1572 

  44. Risso-de Faverney C, Devaux A, Lafaurie M, Girard JP, Bailly B and Rahmani R. Cadmium induces apotosis and genotoxicity in rainbow trout hepatocyte through generation of reactive oxygen species. Aquat Toxicol 2001; 53(1): 65-76 

  45. Roels HA, Lauwery RR, Buchet JP, Bernard A, Chettle DR, Harrey TC and AI-Haddad IK. In vivo measurement of liver and kidney cadmium in workers exposed to this metal: Its significance with repect to cadmium in blood and urine. Environ Res 1981; 26: 217-240 

  46. Schrauzer GN, White DA and Schneider CJ. Cancer morta-lity correlation studies. IV. Associations with dietary intakes and blood levels of certain trace elements, notal-by Se-antagonists. Bioinorg Chem 1972; 7: 35-36 

  47. Sendelbach LE and Klaassen CD. Kidney synthesizes less metallothionein than liver in response to cadmium Chlo-ride and cadmium metallothionein. Toxicol Appl Phar-macol 1988; 92: 95-102 

  48. Shaikh ZA and Lucis UJ. Cadmium and zinc binding in mammalian liver and kidneys. Arch Environ health 1972; 24: 419-425 

  49. Shukla A, Shukla GS and Srimal RC. Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxi-dant potential in rat. Human & Experimental Toxicology 1996: 15(5): 400-405 

  50. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP and Tipton IH. International Commission on Radio-logical Protection. Report of the task group on reference man. New York. ICRP Publication 23.; 1975 

  51. Szuster-Ciesielska A, Stachura A, Slotwinska M, Kaminska T, Sniezko R, Paduch R, Abramczyk D, Filar J and Kan defer-Szerszen M. The inhibitory effect of zinc on Cadi-mium-induced cell apotosis and reactive oxygen species production in cell cultures. Toxicology 2000; 145 (2-3): 159-171 

  52. Taubeneck MW, Daston GP, Rogers JM and Keen CL. AI-tered maternal zinc metabolism following exposure to diverse developmental toxicants. Repro Toxicol 1994; 8: 25-40 

  53. Taubeneck MW, Daston GP, Rogers JM, Gershwin ME, Ansari A and Keen CL. Tumor necrosis factor-alpha alters maternal and embryonic zinc metabolism and is developmentally toxic in mice. J Nutr 1995; 125: 908-919 

  54. Uchida Y, Takio K, Titani K, Ihara Y and Tomonaga M. The growth inhibitory factor that is deficient in the AIzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 1991; 7: 337-347 

  55. Webster WS. Cadmium induced fetal growth retardation in the mouse. Arch Environ Health 1978; 32: 16-22 

  56. WHO (World Health Organization). Cadmium-environ-mental aspects. Environmental Health Criteria 135.; 1992 

  57. Wong KL and Klaassen CD. Tissue retention of cadmium in rats during postnatal development. Toxicol Appl Phar-macol 1980; 53: 343-353 

  58. Wong KL and Klaassen CD. Neurotoxic effects of cadmium in young rats. Toxicol Appl Pharmacol 1982; 63: 330-33 

  59. Wren CD, Harris S and Haittrup N. Ecotoxicology of mer-cury and cadmium, In: Handbook of ecotoxicology. Hoff-man DS, Rattner BA, Burton GA, Jr and J caims, Jr (Eds.), CRC Press, Boca Raton.; 1995. pp. 392-423 

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