[논문]링거액 주입시의 부피팽창 효과에 대한 모델링

이은호; 최규택; 여영구

doi:10.5302/j.icros.2006.12.12.1191

Abstract ▼ AI-Helper

In this work the kinetics of volume changes of fluid spaces associated with infusion of Ringer's solution are analyzed using the body fluid space model. During infusion of Ringer's solution, the human body is assumed to be characterized by the fluid space model into which fluid is fed and from which...

In this work the kinetics of volume changes of fluid spaces associated with infusion of Ringer's solution are analyzed using the body fluid space model. During infusion of Ringer's solution, the human body is assumed to be characterized by the fluid space model into which fluid is fed and from which fluid is left. Various infusion types were tested to accommodate different medical situations. Volunteers were given Ringer's solution and the changes in blood hemoglobin were detected. From the comparison with experimental data, the single- and two-fluid space models were found to represent adequately the kinetics of human volume expansion during infusion of Ringer's solution.

주제어

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문제 정의

But, in some critical situations such as emergent surgery, infusion of Ringer's solution can be represented as a step or an impulse function. The purpose of the present study is to develop clear description on volume expansion caused by various types of infusion of Ringer's solution. Inthis study, we have worked with kinetic models that allow various types of infusion and can be applicable during and after volume loading.

제안 방법

Samples (1 ml each) for measurement of blood hemoglobin concentration were obtained from the radial arterial cannula at 0, 5, 10, 15, 20, 25, 30, 45, 60, 80, 100 and 120 minutes after administration. After a blood sample is drawn, 3ml of Ringer's solution isinjected to flush the cannula and one 2-ml sample to be discarded isdrawn before each blood sampling to avoid undue hemodilution caused by this fluid.
[6] proposed an elementary mathematical models to represent the changes in volume of fluid spaces associated with intravenous administration of a crystalloid solution. They employed experimental results to estimated model parameters but failed to show the effectiveness of the proposed models upon which our study is based. Svensen and Hahn[7] analyzed volume kinetics of Ringer's solution, Dextran 70 and Hypertonic saline in male volunteers.

데이터처리

그림 7. 평균값에 근거한부분 희석도 실험값 비교.

이론/모형

Characteristics of volume expansion effect during infusion of Ringer's solution were analyzed using the single- and two-fluid space models. During infusion of Ringer's solution, the human body is assumed to be characterized by the single- and two-fluid space modelsinto which fluid is fed and from which fluid is left.
In order to check first the effectiveness of the model equations developed in the present study, we assume values of model parameters and target volumes as shown in Table 1 to perform numerical simulations. Simulations were performed using the MATLAB computing tool (version 7.0, MathWorks, U.S.A.). Fig.

참고문헌 (10)

F. Sjstrand, 'Volume kinetics of glucose solutions given by intravenous infusion,' British Journal of Anaesthesia 87 (6): 834-43, 2001

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R. G. Hahn and M. D., Ph.D., 'Kinetics of Isotomic and hypertonic plasma volume expanders,' Anesthesiology 96: 1371-80,2002

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L. Stahle, A. Nilsson, and R. G. Hahn, 'Modelling te volume of expandable body fluid spaces during i.v. fluid therapoy,' British Journal of Anaesthesia 78: 138-143, 1997

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K. I. Brauer, M.D., ''Volume kinetic analysis of the distribution of 0.9% saline in conscious versus Isoflurane-anesthetized sheep,' Anesthesiology 96: 442-9, 2002

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C. Svensen, M.D., ''Volume kinetics of ringer solution, dextran 70, and hypertonic saline in male volunteers,' Anesthesiology 87: 204-12,1997

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R. G. Hahn, D. Drobin, and L. Sthle, 'Volume kinetics of Ringer's solution in female volunteers,' British Journal of Anaesthesia 78: 144-148, 1997

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R. G. Hahn and C. Svensn, 'Plasma dilution and the rate of infusion of Ringer's solution,' British Journal of Anaesthesia 79: 64-67, 1997

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R. G. Hahn, M.D., Ph.D., 'Volume kinetics of ringer's solution in hypovolemic volunteers,' Anesthesiology 90: 81-91,1999

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R. G. Hahn, 'Volume kinetics: a new approach fluid therapy,' Intensivmed 37: 674-679, 2000

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K. I. Brauer, M.D., 'Volume kinetic analysis of the distribution of 0.9% saline in conscious versus Isoflurane-anesthetized sheep,' Anesthesiology 96: 442-9, 2002

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연합인증

링거액 주입시의 부피팽창 효과에 대한 모델링
Modeling of Volume Expansion Effects During Infusion of Ringer's Solution 원문보기

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링거액 주입시의 부피팽창 효과에 대한 모델링 Modeling of Volume Expansion Effects During Infusion of Ringer's Solution 원문보기

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저자의 다른 논문 :

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링거액 주입시의 부피팽창 효과에 대한 모델링
Modeling of Volume Expansion Effects During Infusion of Ringer's Solution 원문보기

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