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종양 표적 유전자 치료
Tumor targeted gene therapy 원문보기

핵의학 분자영상 = Nuclear medicine and molecular imaging, v.40 no.5, 2006년, pp.237 - 242  

강주현 (원자력의학원 핵의학연구실)

Abstract AI-Helper 아이콘AI-Helper

Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic material to an organism with the aim of correcting a disease. The application...

주제어

AI 본문요약
AI-Helper 아이콘 AI-Helper

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제안 방법

  • HSVl-tk에 특이한 기질을 적당한 positron emitter로 표지한 약제를 이용하여 HSVl-tk 유전자 치료과정을 PET영상으로 모니터링하는 연구가 진행되고 있다. Jacob이 뇌종양환자에 tk유전자 치료과정을 1-1247]- 표지된 FIAU로 PET 모니터링한 보고가 있으며, PenuelasS 이 간암환자에게 tk유전자를 아데노바이러스를 이용하여 전달한 후의 유전자의 발현 정도와 위치 등을 F-18이 표지된 FHBG로 모니터링하였다.
본문요약 정보가 도움이 되었나요?

참고문헌 (34)

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