$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

초록이 없습니다.

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

문제 정의

  • 따라서 천식의 면역기전에서 Th1 면역 반응에 대한 관심이 적었다. 그러나 ‘Hygiene hypothesis’는 너무 단순화되어 있는 학설이라는 점과 천식 면역기전에 Th1 면역 반응이 관여한다는 증거가 나오면서 천식 면역 기전으로 innate immunity에 대한 연구가 많이 진행되고 있기에 소개하고자 한다.
  • 본 종설에서는 기도염증 반응에 관여하는 면역학적 기전(IgE-매개성 기전)과 염증매개물질 및 innate immunity에 대하여 설명한다.
본문요약 정보가 도움이 되었나요?

참고문헌 (64)

  1. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001;344:350-62 

  2. Haley KJ, Sunday ME, Wiggs BR, et al. Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med 1998;158:565-72 

  3. Kraft M, Djukanovic R, Wilson S, Holgate ST, Martin RJ. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 1996;154:1505-10 

  4. Vignola AM, Chanez P, Campbell AM, et al. Airway inflammation in mild intermittent and in persistent asthma. Am J Respir Crit Care Med 1998;157: 403-409 

  5. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989;320:271-277 

  6. Noah TL, Becker S. Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus. Clin Immunol 2000;97:43-49 

  7. Schwartz RS. A new element in the mechanism of asthma. N Engl J Med 2002;346:857-858 

  8. National Asthma Education and Prevention Program. Guidelines for the diagnosis and management of asthma. Bethesda, MD: National Heart, Lung, and Blood Institute, National Institutes of Health; 2004 

  9. Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261 

  10. Bacharier LB, Jabara H, Geha RS. Molecular mechanisms of immunoglobulin E regulation. Int Arch Allergy Immunol 1998;115:257-269 

  11. Siraganian RP. Biochemical events in basophil or mast cell activation and mediator release. In: Middleton E Jr, Reed CE, Ellis EF, Adkinson NF Jr, Yunginger JW, Busse WW, eds. Allergy: principles & practice. 5th ed. Vol. 1. St. Louis: Mosby?Year Book, 1998:204-27 

  12. Galli SJ. Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells. J Exp Med 1997;186:343-347 

  13. Lane SJ, Lee TH. Mast cell effector mechanisms. J Allergy Clin Immunol 1996;98:S67-S72 

  14. Clark JM, Abraham WM, Fishman CE, et al. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am J Respir Crit Care Med 1995;152:2076-2083 

  15. Brandenburg AH, van Beek R, Moll HA, Osterhaus ADME, Claas ECJ. G protein variation in respiratory syncytial virus group A does not correlate with clinical severity. J Clin Microbiol 2000;38:3849-3852. 

  16. Peters SP, Zangrilli JG, Fish JE. Late phase allergic reactions. In: Middleton E Jr, Reed CE, Ellis EF, Adkinson NF Jr, Yunginger JW, Busse WW, eds. Allergy: principles & practice. 5th ed. Vol. 1. St. Louis: Mosby?Year Book, 1998:342-55 

  17. Sanderson CJ. Interleukin-5, eosinophils, and disease. Blood 1992;79:3101-3109 

  18. Rothenberg ME. Eosinophilia. N Engl J Med 1998; 338:1592-1600 

  19. Bochner BS. Cellular adhesion and its antagonism. J Allergy Clin Immunol 1997;100:581-585 

  20. Wardlaw AJ. Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm. J Allergy Clin Immunol 1999;104:917-926 

  21. Nagata M, Sedgwick JB, Bates ME, Kita H, Busse WW. Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. J Immunol 1995;155:2194-2202 

  22. Yamamoto H, Sedgwick JB, Busse WW. Differential regulation of eosinophil adhesion and transmigration by pulmonary microvascular endothelial cells. J Immunol 1998;161:971-977 

  23. Hamid QA, Minshall EM. Molecular pathology of allergic disease. I. Lower airway disease. J Allergy Clin Immunol 2000;105:20-36 

  24. Nakamura Y, Ghaffar O, Olivenstein R, et al. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol 1999;103:215-222 

  25. Robinson DS, Hamid Q, Ying S, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304 

  26. Walker C, Bauer W, Braun RK, et al. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. Am J Respir Crit Care Med 1994; 150:1038-1048 

  27. Aubus P, Cosso B, Godard P, et al. Decreased suppressor cell activity of alveolar macrophages in bronchial asthma. Am Rev Respir Dis 1984;130:875-8 

  28. Spiteri M, Knight RA, Jeremy JY, et al. Alveolar macrophage-induced suppression of T-cell hyperresponsiveness in bronchial asthma is reversed by allergen exposure. Eur Respir J 1994;7:1431-1438 

  29. Chung KF, Barnes PJ. Cytokines in asthma. Thorax 1999;54:825-857 

  30. Brewster CEP, Howarth PH, Djukanovic R, et al. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990;3:507-511 

  31. Hirst SJ, Barnes PJ, Twort CHL. Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor. Am J Respir Cell Mol Biol 1992;7:574-581 

  32. Cerutis DR, Nogami M, Anderson JL, et al. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am J Physiol 1997;273:L10-L15 

  33. Lynch KR, O'Neil GP, Liu Q, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999;399:789-93 

  34. Yokomizo T, Izumi T, Chang K, et al. A G-protein- coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 1997;387:620-4 

  35. Stafforini DM, Satoh K, Atkinson DL, et al. Platelet-activating factor acetylhydrolase deficiency : a missense mutation near the active site of an anti-inflammatory phospholipase. J Clin Invest 1996;97:2784-91 

  36. Stafforini DM, Numao T, Tsodikov A, et al. Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. J Clin Invest 1999; 103:989-97 

  37. Levitt RC, McLane MP, MacDonald D, et al. IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders. J. allergy Clin. Immunol. 1999; 103:s485-91.Holroyd KJ, Martinati LC, Trabetti E et al. Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics. 1998; 52:233-5 

  38. McLane MP, Haczku A, van de Rijn M et al. Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. Am J Respir Cell Mol Biol. 1998;19:713-20 

  39. Humbles AA, Lu B, Nilsson CA et al. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature 2000; 161:998-1001 

  40. Karp CL, Grupe A, Schadt E et al. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat. Immunol. 2000;1:221-6 

  41. Chalmers GW, Thomson L, Macleod KJ et al. Endothelin-1 levels in induced sputum samples from asthmatic and normal subjects. Thorax 1997; 100: 544-52 

  42. Redington AE, Springall DR, Ghatei MA et al. Airway endothelin levels in asthma: influence of endobronchial allergen challenge and maintenance corticosteroid therapy. Eur Respir J. 1997; 10: 1026-32 

  43. Redington AE, Springall DR, Meng QH et al. Immunoreactive endothelin in bronchial biopsy specimens: increased expression in asthma and modulation by corticosteroid therapy. J Allergy Clin Immunol. 1997; 100:544-52 

  44. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun. 1991; 181:852-7 

  45. Kharitonov SA, Yates D, Robbins RA et al. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994; 343:133-5 

  46. Massaro AF, Mehta S, Lilly CM et al. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med. 1996; 153:1510-14 

  47. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax. 1998; 53:91-5 

  48. Saleh D, Ernst P, Lim S, Barnes PJ, Giaid A. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 1998;12: 929-37 

  49. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997; 336:1066-71 

  50. Hart LA, Krishnan VL, Adcock IM, Barnes PJ, Chung KF. Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med. 1998: 158 :1585-92 

  51. Selig W, Tocker J. Effect of interleukin-1 receptor antagonist on antigen-induced pulmonary responses in guinea pigs. Eur J Pharmacol. 1992; 213:331-6 

  52. Naseer T, Minshall EM, Leung DY et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. Am J Respir Crit Care Med. 1997; 155:845-51 

  53. Ho AS, Moore KW. Interleukin-10 and its receptor. Ther Immunol. 1994; 1:173-85 

  54. Wang P, Wu P, Siegel MI, Egan RW, Billah MM. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem. 1995; 270:9558-63 

  55. Borish L, Aarons A, Rumbyrt J et al. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol. 1996; 97:1288-96 

  56. John M, Lim S, Seybold J et al. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte- macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med.1998; 157:256-62 

  57. Spiteri MA, Knight RA, Jeremy JY et al. Alveolar macrophage-induced suppression of peripheral blood mononuclear cell responsiveness is reversed by in vitro allergen exposure in bronchial asthma. Eur Respir J. 1994; 7:1431-8 

  58. Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med 2000; 343:338-344 

  59. Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med 2000; 343:338-344 

  60. Eisenbarth SC, Classel S, Bottomly K. Understanding asthma pathogenesis: linking innate and adaptive immunity. Current opinion in Pediatrics 2004; 16:659-665 

  61. Cembrzynska-Nowak M, Szklarz E, Inglot AD, Teodorczyk-Injeyan JA. Elevate release of tumor necrosis factor- $\alpha$ and interferon- $\gamma$ by bron-choalveolar leukocytes from patients with bronchial asthma. Am Rev Respir Dis 1993; 147:291-295 

  62. Krug N, Madden J, Redington AE, Lackie P, Djukanovic R, Schauer U, Holgate ST, Frew AJ, Howarth PH. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996; 14:319-326 

  63. Redecke V, Hacker H, Datta SK et al.: Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 2004; 172:2739-2743 

  64. Walter MJ, Holtzman MJ. A centennial history of research on asthma pathogenesis. Am J Respir Cell Mol Biol 2005; 32:483-489 

저자의 다른 논문 :

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로