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논문 상세정보

혈청의 지질대사에 미치는 목초액 (Pyroligneous Liquor)의 영향

Effect of Pyroligneous Liquor on Lipid Metabolism in Serum of CD Rats

초록

목초액 투여가 생체 지질대사에 미치는 영향을 평가하기 위하여 조아제약에서 개발하여 특허출원한 목초액에서 조제한 시판 목초액 (원액 35% 상당)을 사용하여 0%, 1.0%, 25.0%, 50.0%, 75.0%가 되도록 조제 (control, PL-1, PL-25, PL-50, PL-75 groups)하여 실험용 조제사료로써 8주 동안 자유 음용시킨 다음, 목초액의 지질대사에 미치는 영향을 평가하였다. 목초액 투여에 의한 체중변화 및 사료 섭취률에는 유의적인 영향을 주지 못했다. 그렇지만, 혈청 중의 중성지질의 영향은 목초액 PL-25 및 PL-50 투여군은 대조군 대비 20.5% 및 19.5%의 매우 유의적인 억제효과가 인정되었고, 목초액 PL-75 투여군도 대조군 대비 12%의 유의적인 감소효과가 인정되었다. 목초액 PL-25 및 PL-50 투여군의 총콜레스테롤은 대조군 대비 79.3% 및 83.7%로서 20.7% 및 16.3%의 매우 유의적인 총콜레스테롤 억제효과가 인정되었다. 또한 목초액 PL-25 및 PL-50 투여군은 20.3% 및 16.9%의 유의적 LDL-콜레스테롤의 억제효과가 인정되었을 뿐만 아니라 36.4% 및 25.5%의 HDL-콜레스테롤의 증가효과가 인정되었다. 목초액 PL-25 및 PL-50 투여군은 대조군 대비 각각 37.0% 및 50.0%로 매우 유의적인 동맥경화지수 (AI)의 억제효과가 나타났다. 따라서 목초액의 장기간 투여는 중선지질, 총콜레스테롤 및 LDL-콜레스테롤을 효과적으로 억제할 뿐만 HDL-콜레스테롤을 효과적으로 증가시켜 동맥경화지수(AI)도 효과적으로 억제할 수 있기 때문에 목초액의 장기투여는 성인병의 예방에 효과적일 것으로 기대된다.

Abstract

This study was designed to investigate the effects of pyroligneous liquor on lipid metaboilsm in serum of SPF/VAF Cri/Bgi CD rats. Male CD rats were fed basic diet prepared in our Lab., and PL-0 (control), PL-1, PL-25, PL-50, PL-75 groups were prepared with pyroligneous liquor (35% of Choa Co. Ltd.) of 0%, 1%, 25%, 50% and 75% in purified water per day for 8 weeks. Body weights and food intakes almost did not change in these five groups, and triglyceride (TG) levels were significantly decreased (20.5% and 19.5%, respectively) in these PL-25 and PL-50 groups compared with control group. Total and LDL-cholesterol levels were markedly decreased (20.7%, 16.3% and 20.3%, 116.9%, respectively) in these PL-25 and PL-50% groups, but HDL-cholesterol levels were significantly increased about 36.4% and 25.5% in serum of PL-25 and PL-50 groups compared with control group. Atherogenic indices were also remarkedly decreased (63.0%, and 50%, respectively) in these PL-25 and PL-50 groups compared with control group. These results suggest that long term administration orally of pyroligneous liquor in 25 to 50% may inhibit chronic degenerative disease through improving of lipid metabolism of lower TG & LDL-cholesterol and higher HDL-cholesterol, and lower AJ.

저자의 다른 논문

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이 논문을 인용한 문헌 (12)

  1. Choi, Jin-Ho ; Cho, Weon-Ki 2007. "Effect of Pyroligneous Liquor on Oxygen Radicals and Their Scavenger Enzymes in Liver of CD Rats" 韓國營養學會誌 = The Korean journal of nutrition., 40(2): 111~117 
  2. Seo, Hee-Young ; Jung, Bok-Mi 2007. "Comparative Study of Food Components and Sensory Properties of Common Porphyra yezoensis and Functional Porphyra yezoensis" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 36(10): 1314~1319 
  3. Kim, Sung-Phil ; Nam, Seok-Hyun 2009. "Evaluation and Comparison of Antioxidant Activities of Nineteen Commercial Carbonated Vinegar Liquors" Journal of applied biological chemistry, 52(4): 174~179 
  4. Lee, Soo-Chun ; Kim, Dong-Ki ; Kim, Jae-Woo ; Seo, Hyo-Bin ; Lee, Yoon-Kyung ; Jeon, Byung-Duk ; Lee, Dong-Woon ; Ryu, Sung-Pil 2009. "Effects of Short-Term Ingestion of Wood Vinegar on Antioxidative Defense System in Trained Rats" 韓國資源植物學會誌 = Korean journal of plant resources, 22(4): 330~336 
  5. Kang, Jong-Suk ; Kim, Sea-Hyun ; Kim, Pan-Gi ; Lee, Dong-Woon ; Ryu, Sung-Pil 2009. "Differences of Wood Vinegar Ingestion and Exercise Training on Blood Lipids, MDA, and SOD Activities in Rats" 생명과학회지 = Journal of life science, 19(9): 1190~1199 
  6. Shim, Kwan-Seob ; Ji, Joong-Ryong ; Na, Chong-Sam ; Park, Jae-Hong 2010. "Effect of Pyroligneous Acid Supplementation on Growth Performance, Blood Parameter, Ammonia Gas Emission and Fatty Acid Composition of Breast Meat in Korean Native Chicken" 한국가금학회지 = Korean journal of poultry science, 37(3): 207~213 
  7. Kim, Ho ; Jung, Hye-Mi ; Kim, Sol-Li ; Seo, Un-Kyo 2010. "Effect of Wood Vinegar Produced from Morus alba on Hypersecretion of Airway Mucus" 대한한방내과학회지 = The journal of internal Korean medicine, 31(3): 650~666 
  8. Nam, Dong-Yoon ; Lee, Si-Rim ; Park, Chul-Hong ; Park, Kyu-Sik ; Nam, Sang-Heon ; Heo, Jin-Chul ; Lee, Sang-Han 2010. "Comparison of Anti-Oxidant Activities of Chaff Vinegar Liquor" 한국식품저장유통학회지 = Korean journal of food preservation, 17(3): 430~434 
  9. Choi, Kyung-Soon ; Shin, Kyung-Ok ; Chung, Keun-Hee ; Kim, Yong-Hwan ; Huh, Seon-Min 2012. "The Effect of Goroshoe (Acer mono Max.) Seed Oil, and Magnolia denudata Seed Oil on the Lipid Profile in Serum in Mice" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(4): 770~778 
  10. Choi, Kyung-Soon ; Shin, Kyung-Ok ; Kim, Yong-Hwan ; Yoo, Il-Su ; Jeong, Hun ; Kim, Kyung-Sun ; Lee, Jeong-Sill 2013. "The Effect of Prunus sargentii R. Seed Oil on the Lipid Profile in Serum in Mice" 한국식품영양학회지 = The Korean journal of food and nutrition, 26(4): 670~677 
  11. Chung, Keun-Hee ; Bang, Nam-Hyu ; Shin, Kyung-Ok ; Jung, Tae-Hwan ; Hwang, Hyo-Jeong ; Choi, Kyung-Soon 2013. "Effects of Pyroligneous Liquor on Olive, Flaxseed and Perilla Oils in Lipid Metabolism of Mice" 한국식품영양학회지 = The Korean journal of food and nutrition, 26(2): 242~248 
  12. Shin, Kyung-Ok ; Kim, Yong-Hwan ; Lee, Ki-Won ; Choi, Kyung-Soon 2015. "Effect of In Vitro Antioxidant Properties and Extract of Corn Husk on Serum Lipids in Mice" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 25(2): 261~269 

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