돼지고기 섭취 시 우리 체내에 축적되는 납의 중독을 완화시킬 수 있는가를 살피고자 흰쥐에 7주동안 납의 임상적인 중독현상을 유발시키고 이어서 7주 동안 납을 중단하고 해독과정을 유발시키면서 돼지고기 투여에 의한 납 해독 효과를 비교하는 시험을 실시하였다. 납 중독에 의해 체중저하, 헤모글로빈과 헤마토크릿 저하, 상대적 간과 신장의 무게 증가, 대퇴골, 신장, 간에서의 납 축적 등을 확인하였다. 해독 시에 돼지고기를 섭취시킨 경우 유의적으로 식이 효율이 높아졌다. 또한 돼지고기 섭취가 상대적 간과 신장의 상대적 무게에 영향을 주는 인자인 것으로 나타났다(p<0.05). 간에서의 납 축적에 영향을 미치는 요인으로는 납 중독 여부(p<0.0005), 돼지고기 섭취(p<0.0005), 납과 돼지고기 섭취의 상호작용(p<0.0005)이 모두 작용하는 것으로 나타났다. 간에 있는 DALAD함량은 대조구에 비해서 돼지고기 첨가구에서 납 첨가 수준에 관계없이 유의적으로 높아졌음을 볼 수 있었다. 이 결과로서 돼지고기가 납에 중독된 흰쥐에서 해독과정을 향상시킬 수 있는 것으로 사료되었다.
돼지고기 섭취 시 우리 체내에 축적되는 납의 중독을 완화시킬 수 있는가를 살피고자 흰쥐에 7주동안 납의 임상적인 중독현상을 유발시키고 이어서 7주 동안 납을 중단하고 해독과정을 유발시키면서 돼지고기 투여에 의한 납 해독 효과를 비교하는 시험을 실시하였다. 납 중독에 의해 체중저하, 헤모글로빈과 헤마토크릿 저하, 상대적 간과 신장의 무게 증가, 대퇴골, 신장, 간에서의 납 축적 등을 확인하였다. 해독 시에 돼지고기를 섭취시킨 경우 유의적으로 식이 효율이 높아졌다. 또한 돼지고기 섭취가 상대적 간과 신장의 상대적 무게에 영향을 주는 인자인 것으로 나타났다(p<0.05). 간에서의 납 축적에 영향을 미치는 요인으로는 납 중독 여부(p<0.0005), 돼지고기 섭취(p<0.0005), 납과 돼지고기 섭취의 상호작용(p<0.0005)이 모두 작용하는 것으로 나타났다. 간에 있는 DALAD함량은 대조구에 비해서 돼지고기 첨가구에서 납 첨가 수준에 관계없이 유의적으로 높아졌음을 볼 수 있었다. 이 결과로서 돼지고기가 납에 중독된 흰쥐에서 해독과정을 향상시킬 수 있는 것으로 사료되었다.
To investigate the detoxification effect of pork on the lead toxicity, the comparison tests were performed, in which Sprague Dawley(SD) rats were clinically treated with lead during the first 7 weeks and observed the detoxification effects induced by pork feeding during the second 7 weeks. As result...
To investigate the detoxification effect of pork on the lead toxicity, the comparison tests were performed, in which Sprague Dawley(SD) rats were clinically treated with lead during the first 7 weeks and observed the detoxification effects induced by pork feeding during the second 7 weeks. As results of lead intoxication, decreases of body weight, hemoglobin and hematocrit and the increases of weight and relative organ weight of liver and kidney were observed. Also the accumulation of lead in tibia, kidney and liver was recognized. In case of pork feeding at detoxification stage the feed efficiency was significantly increased in pork feeding group rats than the those of control rats. The pork feeding seemed to be a factor affecting relative organ weight of liver and kidney(p<0.05). It was shown that the factors affecting the accumulation of lead in liver included the lead intoxication(p<0.0005), pork feeding(p<0.0005) and interaction of above two(p<0.0005). It was observed that the content of DALAD in liver increased with significance in pork fed group compared with control group regardless of lead treatment levels. From this result, it was considered that pork feeding improved the detoxification process of SD rats intoxicated with lead.
To investigate the detoxification effect of pork on the lead toxicity, the comparison tests were performed, in which Sprague Dawley(SD) rats were clinically treated with lead during the first 7 weeks and observed the detoxification effects induced by pork feeding during the second 7 weeks. As results of lead intoxication, decreases of body weight, hemoglobin and hematocrit and the increases of weight and relative organ weight of liver and kidney were observed. Also the accumulation of lead in tibia, kidney and liver was recognized. In case of pork feeding at detoxification stage the feed efficiency was significantly increased in pork feeding group rats than the those of control rats. The pork feeding seemed to be a factor affecting relative organ weight of liver and kidney(p<0.05). It was shown that the factors affecting the accumulation of lead in liver included the lead intoxication(p<0.0005), pork feeding(p<0.0005) and interaction of above two(p<0.0005). It was observed that the content of DALAD in liver increased with significance in pork fed group compared with control group regardless of lead treatment levels. From this result, it was considered that pork feeding improved the detoxification process of SD rats intoxicated with lead.
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