$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

뇌 신경물질 운반체 영상용 방사성의약품
Radiopharmaceuticals for Neurotransmitter Imaging 원문보기

핵의학 분자영상 = Nuclear medicine and molecular imaging, v.41 no.2, 2007년, pp.118 - 131  

오승준 (울산대학교 의과대학 서울아산병원 핵의학과)

Abstract AI-Helper 아이콘AI-Helper

Neurotransmitter imaging with radiopharmaceuticals plays major role for understanding of neurological and psychiatric disorders such as Parkinson's disease and depression. Radiopharmaceuticals for neurotransmitter imaging can be divided to dopamine transporter imaging radiopharmaceuticals and seroto...

주제어

참고문헌 (50)

  1. Piccini PP. Dopamine transporter: basic aspects and neuroimaging. Mov Disord 2003;18(Suppl 7):S3-8 

  2. Au WL, Adams JR, Troiano AR, Stoessl AJ. Parkinson's disease: in vivo assessment of disease progression using positron emission tomography. Brain Res Mol Brain Res 2005;134:24-33 

  3. Neumeyer JL, Wang S, Gao Y, Milius RA, Kula NS, Campbell A, et al. N- $\omega$ Fluoroalkyl analogs of (1R)-2 $\beta$ -carbomethoxy-3 $\beta$ -(4-iodophenyl)-tropane ( $\beta$ -CIT): Radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporter. J Med Chem 1994;37:1558-61 

  4. Kung HF, Kung MP, Choi SR. Radiopharmaceuticals for single-photon emission computed tomography brain imaging. Semin Nucl Med 2003;33:2-13 

  5. Laruelle M, Baldwin RM, Malison RT, Zea-Ponce Y, Zoghbi SS, al-Tikriti MS, et al. SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse 1993;13:295-309 

  6. Frost JJ, Rosier AJ, Reich SG, Smith JS, Ehlers MD, Snyder SH, et al. Positron emission tomographic imaging of the dopamine transporter with $^{11}C$ -WIN 35,428 revelas marked declines in mild Parkinson's disease. Ann Neurol 1993;34:423-31 

  7. Lundkvist C, Halldin C, Swahn CG, Hall H, Karlsson P, Nakashima Y, et al. [O-methyl- $^{11}C$ ]beta-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: preparation, autoradiography, metabolite studies, and positron emission tomography examinations. Nucl Med Biol 1995;22:905-13 

  8. Huang WS, Lee MS, Lin JC, Chen CY, Yang YW, Lin SZ, et al. Usefulness of brain $^{99m}Tc$ -TRODAT-1 SPET for the evaluation of Parkinson's disease. Eur J Nucl Med Mol Imaging 2004;31:155-61 

  9. Vanbilloen HP, Kieffer DM, Cleynhens BJ, Bormans GM, Mortelmans L, Verbruggen AM. Evaluation of $^{99m}Tc$ -labeled tropanes with alkyl substituents on the 3beta-phenyl ring as potential dopamine transporter tracers. Nucl Med Biol 2006;33: 413-8 

  10. Okada T, Fujita M, Shimada S, Sato K, Schloss P, Watanabe Y, Itoh Y, Tohyama M, Nishimura T. Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines. Nucl Med Biol 1998;25:53-8 

  11. Lundkvist C, Halldin C, Ginovart N, Swahn CG, Farde L. [ $^{18}F $ ] beta-CIT-FP is superior to [ $^{11}C $ ] beta-CIT-FP for quantitation of the dopamine transporter. Nucl Med Biol 1997;24:621-7 

  12. Goodman MM, Kilts CD, Keil R, Shi B, Martarello L, Xing D, et al. $^{18}F$ -labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nucl Med Biol 2000;27:1-12 

  13. Zoghbi SS, Shetty HU, Ichise M, Fujita M, Imaizumi M, Liow JS, et al. PET imaging of the dopamine transporter with $^{18}F $ -FECNT : apolar radiometabolite confounds brain radioligand measurements. J Nucl Med 2006;47:520-7 

  14. Prunier C, Payoux P, Guilloteau D, Chalon S, Giraudeau B, Majorel C, et al. Quantification of dopamine transporter by $^{123}I $ -PE2I SPECT and the noninvasive Logan graphical method in Parkinson's disease. J Nucl Med 2003;44:663-70 

  15. Kim HJ, Im JH, Yang SO, Moon DH, Ryu JS, Bong JK, et al. Imaging and quantitation of dopamine transporters with iodine- 123-IPT in normal and Parkinson's disease subjects. J Nucl Med 1997;38:1703-11 

  16. Dolle F, Emond P, Mavel S, Demphel S, Hinnen F, Mincheva Z, et al. Synthesis, radiosynthesis and in vivo preliminary evaluation of [ $^{11}C $ ]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET. Bioorg Med Chem 2006;14: 1115-25 

  17. Chalon S, Hall H, Saba W, Garreau L, Dolle F, Halldin C, et al. Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2betacarbomethoxy- 3beta-( $4^+$ -tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter. J Pharmacol Exp Ther 2006;317:147-52 

  18. Saba W, Valette H, Schollhorn-Peyronneau MA, Coulon C, Ottaviani M, Chalon S, et al. [ ${11}C$ ]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET. Synapse 2007;61:17-23 

  19. Dolle F, Hinnen F, Emond P, Mavel P, Mincheva Z, Saba W, et al. Radiosynthesis of [ ${18}F$ ]LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET. J Label Compd Radiopharm 2006;49:687-98 

  20. Chaly T, Dhawan V, Kazumata K, Antonini A, Margouleff C, Dahl JR, et al. Radiosynthesis of [ $^{18}F$ ] N-3-fluoropropyl-2-betacarbomethoxy- -beta-(4-iodophenyl) nortropane and the first human study with positron emission tomography. Nucl Med Biol 1996; 23:999-1004 

  21. Robeson W, Dhawan V, Belakhlef A, Ma Y, Pillai V, Chaly T, et al. Dosimetry of the dopamine transporter radioligand 18F-FPCIT in human subjects. J Nucl Med 2003;44:961-6 

  22. Kim DW, Ahn DS, Oh YH, Lee S, Kil HS, Oh SJ, et al. A new class of ${SN}_2$ reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules. J Am Chem Soc 2006;128:16394-7 

  23. Aquilonius SM, Bergstrom K, Eckernas SA, Hartvig P, Leenders KL, Lundkvist H, et al. In vivo evaluation of striatal dopamine reuptake sites using $^{11}C$ -Nomifesin and positron emission tomography. Acta Neurol Scand 1987;76:283-87 

  24. Booji J, Hemelaar J, Speelman JD, Bruin K, Janssen A, Royen EA. One-day protocol for imaging of the nigrostriatal dopaminergic pathway in Parkinson's disease by [ $^{123}I$ ]FP-CIT SPECT. J Nucl Med 1999;40:753-61 

  25. Kazumata K, Dhawan V, Chaly T, Antonini A, Margouleff C, Belakhlef A, et al. Dopamine transporter imaging with fluorine- 18-FPCIT and PET. J Nucl Med 1998;39:1521-30 

  26. Lee SJ, Oh SJ, Kim JS, Chi DY, Lim KC, Lim SJ, et al. Preclinical studies of [F-18]Fluoropropyl-arbomethoxyIodonortropane (FP-CIT). 2006 World J Nucl Med 2006;5:S38 

  27. Huang Y, Hwang DR, Narendran R, Sudo Y, Chatterjee R, Bae SA, et al. Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [ $^{11}C$ ]McN 5652, [ $^{11}C$ ]ADAM, [ $^{11}C$ ]DASB, [ $^{11}C$ ]DAPA, and [ $^{11}C$ ]AFM. J Cereb Blood Flow Metab 2002;22:1377-98 

  28. Hashimoto K, Inoue O, Suzuki K, Yamasaki T, Kojima M. Synthesis and evaluation of [ $^{11}C$ ]cyanoimipramine. Int J Rad ApplInstrum [B] 1987;14:587-92 

  29. Lasne MC, Pike VW, Turton DR. The radiosynthesis of [N-methyl- $^{11}C$ ]-sertraline. Int J Rad Appl Instrum [A] 1989;40: 147-51 

  30. Livni E, Satterlee W, Robey RL, Alt CA, Van Meter EE, Babich JW, et al. Synthesis of [ $^{11}C$ ]dapoxetine.HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey. Nucl Med Biol 1994;21:669-75 

  31. Scheffel U, Dannals RF, Suehiro M, Ricaurte GA, Carroll FI, Kuhar MJ, et al. Development of PET/SPECT ligands for the serotonin transporter. NIDA Res Monogr 1994;138:111-30 

  32. Dannals RF, Ravert HT, Wilson AA, Wagner HN Jr. Synthesis of a selective serotonin uptake inhibitor: [ $^{11}C$ ]citalopram. Int J Rad Appl Instrum [A] 1990;41:541-43 

  33. Suehiro M, Scheffel U, Dannals RF, Wilson AA, Ravert HT, Wagner HN Jr. Synthesis and biodistribution of a new radiotracer for in vivo labeling of serotonin uptake sites by PET, cis-N,N-[ $^{11}C$ ]dimethyl-3-(2',4'-dichlorophenyl)-indanamine (cis-[ $^{11}C$ ]DDPI). Int J Rad Appl Instrum B. 1992;19:549-53 

  34. Zea-Ponce Y, Baldwin RM, Stratton MD, Al-Tikriti M, Souffer R, Schauss JM, et al. Radiosynthesis and PET imaging of [N-methyl- $^{11}C$ ]LY257327 as a tracer for 5-HT transporters. Nucl Med Biol 1997;24:251-54 

  35. Smith DF, Jensen PN, Gee AD, Hansen SB, Danielsen E, Andersen F, et al. PET neuroimaging with [ $^{11}C$ ]venlafaxine:serotonin uptake inhibition, biodistribution and binding in living pig brain. Eur Neuropsychopharmacol 1997;7:195-200 

  36. Bergstrom KA, Halldin C, Hall H, Lundkvist C, Ginovart N, Swahn CG, et al. In vitro and in vivo characterisation of norbeta-CIT: a potential radioligand for visualisation of the serotonin transporter in the brain. Eur J Nucl Med 1997;24:596-601 

  37. Jagust WJ, Eberling JL, Biegon A, Taylor SE, VanBrocklin HF, Jordan S, et al. Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter. J Nucl Med 1996;37:1207-1214 

  38. Lundkvist C, Loc'h C, Halldin C, Bottlaender M, Ottaviani M, Coulon C, et al. Characterization of bromine-76-labeled 5-bromo- 6-nitroquipazine for PET studies of the serotonin transporter. Nucl Med Biol 1999;26:501-507 

  39. Suehiro M, Scheffel U, Ravert HT, Dannals RF, Wagner HN Jr. [ $^{11}C$ ](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET. Life Sci 1993;53:883-92 

  40. Suehiro M, Wilson AA, Scheffel U, Dannals RF, Ravert HT, Wagner HN Jr. Radiosynthesis and evaluation of N-(3- [ $^{18}F$ ]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET. Int J Rad Appl Instrum B 1991;18:791-6 

  41. Oya S, Kung MP, Acton PD, Mu M, Hou C, Kung HF. A new single-photon emission computed tomography imaging agent for serotonin transporters: [ $^{123}I$ ]IDAM, 5-iodo-2-((2-((dimethylamino) methyl)phenyl)thio)benzyl alcohol. J Med Chem 1999;42:333-5 

  42. Oya S, Choi SR, Kung MP, Kung HF. 5-Chloro-2-(2'- ((dimethylamino) methyl)-4'-iodophenylthio) benzenamine: a new serotonin transporter ligand. Nucl Med Biol 2007;34:129-39 

  43. Huang Y, Hwang DR, Zhu Z, Bae SA, Guo N, Sudo Y, et al. Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [ $^{11}C$ ]5-bromo-2-[2-(dimethyl aminomethylphenylsulfanyl)] phenylamine ([ $^{11}C$ ]DAPA). Nucl Med Biol 2002;29:741-51 

  44. Wilson AA, Ginovart N, Hussey D, Meyer J, Houle S. In vitro and in vivo characterisation of [ $^{11}C$ ]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography. Nucl Med Biol 2002;29:509-15 

  45. Zhu Z, Guo N, Narendran R, Erritzoe D, Ekelund J, Hwang DR, et al. The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. Nucl Med Biol 2004;31:983-94 

  46. Huang Y, Hwang DR, Bae SA, Sudo Y, Guo N, Zhu Z, et al. Anew positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [ $^{11}C$ ]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylam ine ([ $^{11}C$ ]AFM). Nucl Med Biol 2004;31:543-56 

  47. Huang Y, Narendran R, Bae SA, Erritzoe D, Guo N, Zhu Z, et al. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [ $^{11}C$ ]2-[2-dimethylaminomethyl phenylthio)]-5-fluorophenylamine ([ $^{11}C$ ]AFA). Nucl Med Biol 2004;31:727-38 

  48. Vercouillie J, Mavel S, Galineau L, Ragusa T, Innis R, Kassiou M, et al. Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. Bioorg Med Chem Lett 2006;16:1297-300 

  49. Jarkas N, McConathy J, Voll RJ, Goodman MM. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'- substituted-phenylthio) benzylamines: potential candidates as selective serotonin transporter radioligands. J Med Chem 2005; 48:4254-65 

  50. Huang Y, Bae SA, Zhu Z, Guo N, Roth BL, Laruelle M. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. J Med Chem 2005;48:2559-70 

LOADING...

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로