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논문 상세정보

산수유 씨의 최종당화산물 생성저해활성 성분

Constituents of the seeds of Cornus officinalis with Inhibitory Activity on the Formation of Advanced Glycation End Products (AGEs)

초록

과육을 제거한 산수유 씨의 MeOH 추출물의 EtOAc 분획물로부터 이용하여 10종의 화합물을 분리하였다. 이들 중에서 (+)- pinoresinol, (-)-balanophonin, vanillin, 4-hydroxybenzaldehyde, coniferaldehyde, betulinic acid는 이 식물에서 처음으로 분리된 물질들이다. 본 연구에서 분리된 10종의 화합물에 대한 in vitro 최종당화산물(AGEs) 생성억제효능 실험결과, (-)-balanophonin (화합물 2)과 gallicin(화합물 3)이 각각 $IC_{50}$ 값 27.81과 18.04${\mu}M$로 비교양성대조군인 aminoguanidine(974.59 ${\mu}M$)보다 훨씬 우수한 효능을 나타내었다.

Abstract

Ten compounds, (+)-pinoresinol (1), (-)-balanophonin (2), gallicin (3), vanillin (4), 4-hydroxybenzaldehyde (5), coniferaldehyde (6), betulinic acid (7), ursolic acid (8), 5-hydroxymethyl furfural (9), and malic acid (10), were isolated from a EtOAc-soluble fraction of the seeds of Cornus officinalis. The structures of these compounds were elucidated by spectroscopic methods as well as by comparison with reported values. Compounds 1, 2, and 4-7 were isolated from this species for the first time. All the isolates (1-10) were subjected to an in vitro bioassay to evaluate their inhibitory activity against advanced glycation end products (AGEs) formation. Among these, compounds 2 and 3 showed the significant inhibitory activity on AGEs formation with $IC_{50}$ values of 27.81 and 18.04${\mu}M$, respectively.

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이 논문을 인용한 문헌 (4)

  1. Kim, Young-Sook ; Choi, Sung-Hoon ; Kim, Joo-Hwan ; Kim, Jin-Sook 2011. "Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (V)" 생약학회지, 42(1): 46~53 
  2. Choi, So-Jin ; Kim, Young Sook ; Song, Yoo Jin ; Lee, Yun Mi ; Kim, Joo Hwan ; Kim, Jin Sook 2012. "Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (VII)" 생약학회지, 43(4): 345~351 
  3. Kim, Min-A ; Duan, Yishan ; Seong, Jong-Hwan ; Chung, Hun-Sik ; Kim, Han-Soo 2014. "Antioxidative Activity of Feral Haw (Crataegus pinnatifida BUNGE) Seed Extracts Using Various Solvents" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 30(1): 33~40 
  4. Duan, Yishan ; Kim, Min-A ; Kim, Han-Soo ; Seong, Jong-Hwan ; Lee, Young-Guen ; Kim, Dong-Seob ; Chung, Hun-Sik 2014. "Effects of Feral Haw (Crataegus pinnatifida BUNGE) Seed Extracts on the Antioxidant Activities" 생명과학회지 = Journal of life science, 24(4): 386~392 

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