[논문]마렉병 바이러스 감염에 대한 면역 반응

장형관; 박영명; 차세연; 박종범

doi:10.5536/kjps.2008.35.3.225

[국내논문] 마렉병 바이러스 감염에 대한 면역 반응
Immune Responses against Marek's Disease Virus Infection 원문보기

한국가금학회지 = Korean journal of poultry science, v.35 no.3, 2008년, pp.225 - 240

장형관 (전북대학교 수의과대학 전염병학.조류질병학연구실) , 박영명 (전북대학교 수의과대학 전염병학.조류질병학연구실) , 차세연 (전북대학교 수의과대학 전염병학.조류질병학연구실) , 박종범 (전북대학교 수의과대학 전염병학.조류질병학연구실)

Abstract ▼ AI-Helper

Marek's disease virus(MDV) is a highly cell-associated, lymphotropic $\alpha$-herpesvirus that causes paralysis and neoplastic disease in chickens. The disease has been controlled by vaccination which was provided the first evidence for a malignant cancer being controlled by an antiviral vaccine. Marek's disease pathogenesis is complex, involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of $CD4^+$ T cells in susceptible chickens. MDV targets a number of different cell types during its life cycle. Lymphocytes play an essential role, although within them virus production is restricted and only virion are produced. Innate and adaptive immune responses develop in response to infection, but infection of lymphocytes results in immunosuppressive effects. Hence in MDV-infected birds, MDV makes its host more vulnerable to tumour development as well as to other pathogens. All chickens are susceptible to MDV infection, and vaccination is essential to protect the susceptible host from developing clinical disease. Nevertheless, MDV infects and replicates in vaccinated chickens, with the challenge virus being shed from the feather-follicle epithelium. The outcome of infection with MDV depends on a complex interplay of factors involving the MDV pathotype and the host genotype. Host factors that influence the course of MD are predominantly the responses of the innate and adaptive immune systems, and these are modulated by: age at infection and maturity of the immune system; vaccination status; the sex of the host; and various physiological factors.

Keyword

질의응답

핵심어	질문	논문에서 추출한 답변
	마렉병 바이러스는 어떻게 전파되는가?	1). MDV는 고도의 세포 의존성 바이러스이기 때문에 바이러스 감염 및 전파가 세포간 접촉을 통해 이루어지고, 바이러스 유전체도 감염세포가 세포분열을 통해 자매 세포를 형성하는 세포분열 과정을 통해 전파된다(Kaleta and Neumann, 1977). 바이러스는 여러 종류의 세포에 감염할 수 있지만 감염에 표적이 되는 주된 세포는 활성화 과정에 있거나 활성화된 림프구이다.
	바이러스 감염에 주된 표적이 되는 세포는 무엇인가?	MDV는 고도의 세포 의존성 바이러스이기 때문에 바이러스 감염 및 전파가 세포간 접촉을 통해 이루어지고, 바이러스 유전체도 감염세포가 세포분열을 통해 자매 세포를 형성하는 세포분열 과정을 통해 전파된다(Kaleta and Neumann, 1977). 바이러스는 여러 종류의 세포에 감염할 수 있지만 감염에 표적이 되는 주된 세포는 활성화 과정에 있거나 활성화된 림프구이다. 따라서 MDV에 감염된 조류에서 일부의 림프구는 감염을 억제하는 방어 면역 형성에 관여하지만, 일부분은 바이러스 전파 과정에 표적 세포로 작용하여 병원성을 유발시키는 원인으로 작용하기도 한다.
	림프구 감염에 의한 바이러스 독성으로 인해 일어날 수 있는 일은 무엇이 있는가?	따라서 MDV에 감염된 조류에서 일부의 림프구는 감염을 억제하는 방어 면역 형성에 관여하지만, 일부분은 바이러스 전파 과정에 표적 세포로 작용하여 병원성을 유발시키는 원인으로 작용하기도 한다. 림프구 감염에 의한 바이러스 독성으로 인해 숙주의 면역 체계가 약화되면 이로 인해 종양 유발뿐만 아니라 다른 병원체 감염에 대한 감수성을 증가시키는 원인으로 작용하게 된다. 바이러스 감염에 대한 감수성은 면역의 성숙 정도에 차이 없이 모든 일령의 닭에서 나타나지만, 백신을 통한 방어 면역 형성이 임상 증상 유발로부터 감수성이 있는 숙주를 방어할 수 있는 효과적인 수단으로 활용되어 바이러스의 폭넓은 감수성에 의한 피해를 감소시키고 있다.

참고문헌 (57)

Balu S, Kaiser P 2003 Avian interleukin-12beta (p40): cloning and characterization of the cDNA and gene. J Interferon Cytokine Res 23:699-707

상세보기
Barrow AD, Burgess SC, Baigent SJ, Howes K, Nair VK 2003 Infection of macrophages by a lymphotropic herpesvirus: a new tropism for Marek's disease virus. J Gen Virol 84: 2635-2645

상세보기
Brunovskis P, Chen X, Velicer LF 1992 Analysis of Marek's disease virus glycoproteins D, I and E. Pages 118-122. In Proceedings of the 19th World's Poultry Congress, vol. 1. 4th International Symposium on Marek's Disease. Ponsen and Looijen, Wageningen
Bumstead JM, Payne LN 1987 Production of an immune suppressor factor by Marek's disease lymphoblastoid cell lines. Vet Immunol Immunopathol 16:47-66

상세보기
Bumstead N 1998 Genetic resistance to avian viruses. Rev Sci Tech. 17:249-255

상세보기
Burgess SC, Davison TF 2002 Identification of the neoplastically transformed cells in Marek's disease herpesvirus-induced lymphomas: recognition by the monoclonal antibody AV37. J Virol 76:7276-7292

상세보기
Burgess SC, Basaran BH, Davison TF 2001 Resistance to Marek's disease herpesvirus-induced lymphoma is multiphasic and dependent on host genotype. Vet Pathol 38:129-142

상세보기
Burgoyne GH, Witter RL 1973 Effect of passively transfered immunoglobulins on Marek's disease. Avian Dis. 17:824-837

상세보기
Buscaglia C, Calnek BW 1988a Maintenance of Marek's disease herpesvirus latency in vitro by a factor found in conditioned medium. J Gen Virol 69:2809-2818

상세보기
Buscaglia C, Calnek BW, Schat KA 1988b Effect of immunocompetence on the establishment and maintenance of latency with Marek's disease herpesvirus. J Gen Virol 69:1067-77

상세보기
Calnek BW 1972 Effects of passive antibody on early pathogenesis of Marek's disease. Infect Immun 6:193-198

상세보기
Calnek BW, Schat KA, Ross LJ, Chen CL 1984 Further characterization of Marek's disease virus-infected lymphocytes. II. In vitro infection. Int J Cancer 33:399-406

상세보기
Cerwenka A, Lanier LL 2001 Natural killer cells, viruses and cancer. Nat Rev Immunol 1:41-49

상세보기
Chubb RC, Churchill AE 1969 Effect of maternal antibody on Marek's disease. Vet Rec 85:303-305

상세보기
Churchill AE, Chubb RC, Baxendale W 1969 The attenuation, with loss of oncogenicity, of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture. J Gen Virol 4:557-564

상세보기
Dandapat S, Pradhan HK, Mohanty GC 1994 Anti-idiotype antibodies to Marek's disease-associated tumour surface antigen in protection against Marek's disease. Vet Immunol Immunopathol. 40:353-366

상세보기
Davison F, Kaiser P 2004 Immunity to Marek's disease. Pages 126-141 In: Marek's disease(an evolving problem). Davison F and Nair V, (Ed.) Elsevier Academic Press, New York
Djeraba A, Musset E, Bernardet N, Le Vern Y, Quere P 2002a Similar pattern of iNOS expression, NO production and cytokine response in genetic and vaccination-acquired resistance to Marek's disease. Vet Immunol Immunopathol 85: 63-75

상세보기
Djeraba A, Musset E, Lowenthal JW, Boyle DB, Chausse AM, Peloille M, Quere P 2002b Protective effect of avian myelomonocytic growth factor in infection with Marek's disease virus. J Virol 76:1062-1070

상세보기
Garcia-Camacho L, Schat KA, Brooks R Jr, Bounous DI 2003 Early cell-mediated immune responses to Marek's disease virus in two chicken lines with defined major histocompatibility complex antigens. Vet Immunol Immunopathol 95:145-153

상세보기
Gupta MK, Chauhan HV, Jha GJ, Singh KK 1989 The role of the reticuloendothelial system in the immunopathology of Marek's disease. Vet Microbiol 20:223-234

상세보기
Haffer K, Sevoian M, Wilder M 1979 The role of the macrophages in Marek's disease: in vitro and in vivo studies. Int J Cancer 23:648-656

상세보기
Heller ED, Schat KA 1987 Enhancement of natural killer cell activity by Marek's disease vaccines. Avian Pathol 16:51-60

상세보기
Higgins DA, Calnek BW 1976 Some effects of silical treatment on Marek's disease. Infect Immun 13:1054-1060
Hong CC, Sevoian M 1971 Interferon production and host resistance to type II avian (Marek's) leukosis virus (JM strain). Appl Microbiol 22:818-820

상세보기
Kaiser P, Underwood G, Davison F 2003 Differential cytokine responses following Marek's disease virus infection of chickens differing in resistance to Marek's disease. J Virol 77: 762-768

상세보기
Kaleta HD, Neumann U 1977 Investigations on the model of transmission of the herpesvirus of turkeys in vitro. Avian Pathol 6:33-39

상세보기
Keller LH, Lillehoj HS, Solonsky JM 1992 JMV-1 stimulation of avian natural killer cell activity. Avian Pathol 21:239-250

상세보기
Kodama H, Mikami T, Inoue M, Izawa H 1979 Inhibitory effects of macrophages against Marek's disease virus plaque formation in chicken kidney cell cultures. J Natl Cancer Inst 63:1267-1271
Lam KM, Linna TJ 1979 Transfer of natural resistance to Marek's disease (JMV) with non-immune spleen cells. I. Studies of cell population transferring resistance. Int J Cancer 24: 662-667

상세보기
Lee LF, Sharma JM, Nazerian K, Witter RL 1978 Suppression and enhancement of mitogen response in chickens infected with Marek's disease virus and the herpesvirus of turkeys. Infect Immun 21:474-479
Lee LF, Witter RL 1991 Humoral immune responses to inactivated oil-emulsified Marek's disease vaccine. Avian Dis 35:452-459

상세보기
Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B 1998 B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187:655-660

상세보기
Liu JL, Lin SF, Xia L, Brunovskis P, Li D, Davidson I, Lee LF, Kung HJ 1999 MEQ and V-IL8: cellular genes in disguise? Acta Virol 43:94-101

상세보기
Loeffler DA, Schat KA, Norcross NL 1986 Use of $^{51}Cr$ release to measure the cytotoxic effects of staphylococcal leukocidin and toxin neutralization on bovine leukocytes. J Clin Microbiol 23:416-420

상세보기
Morimura T, Ohashi K, Sugimoto C, Onuma M 1998 Pathogenesis of Marek's disease (MD) and possible mechanisms of immunity induced by MD vaccine. J Vet Med Sci 60:1-8

상세보기
Omar AR, Schat KA 1996 Syngeneic Marek's disease virus (MDV)-specific cell-mediated immune responses against immediate early, late, and unique MDV proteins. Virology 222: 87-99

상세보기
Payne LN, Frazier JA 1976 Powell PC pathogenesis of Marek's disease. Int Rev Exp Pathol. 16:59-154
Powell PC 1975 Immunity to Marek's disease induced by glutaraldehyde-treated cells of Marek's disease lymphoblastoid cell lines. Nature 257:684-685

상세보기
Powell PC, Hartley KJ, Mustill BM, Rennie M 1983 Studies on the role of macrophages in Marek's disease of the chicken. J Reticuloendothel Soc 34:289-297

상세보기
Powell PC, Davison TF 1986 Induction of Marek's disease in vaccinated chickens by treatment with betamethasone or corticosterone. Israel J Vet Med. 42:73-78
Quere P, Dambrine G 1988 Development of anti-tumoral cell-mediated cytotoxicity during the course of Marek's disease in chickens. Ann Rech Vet 19:193-201
Qureshi MA, Miller L 1991 Comparison of macrophage function in several commercial broiler genetic lines. Poult Sci 70:2094-2101

상세보기
Ross LJ 1977 Antiviral T cell-mediated immunity in Marek's disease. Nature 268:644-646

상세보기
Schat KA, Calnek BW, Weinstock D 1986 Cultivation and characterisation of avian lymphocytes with natural killer cell activity. Avian Pathol 15:539-556

상세보기
Schat KA 1991 Importance of cell-mediated immunity in Marek's disease and other viral tumor diseases. Poult Sci 70: 1165-1175

상세보기
Schat KA, Markowski-Grimsrud CJ 2001 Immune responses to Marek's disease virus infection. Curr Top Microbiol Immunol 255:91-120

상세보기
Schumacher D, Tischer BK, Fuchs W, Osterrieder N 2000 Reconstitution of Marek's disease virus serotype 1 (MDV-1) from DNA cloned as a bacterial artificial chromosome and characterization of a glycoprotein B-negative MDV-1 mutant. J Virol 74:11088-11098

상세보기
Secombes CJ, Kaiser P 2003 The phylogeny of cytokines. Pages 57-84 In : The Cytokine Handbook, 4th ed. Thomson A, Lotze MT (eds) Academic Press, London
Sharma JM, Coulson BD 1979 Presence of natural killer cells in specific-pathogen-free chickens. J Natl Cancer Inst 63: 527-531
Sharma JM, Okazaki W 1981 Natural killer cell activity in chickens: target cell analysis and effect of antithymocyte serum on effector cells. Infect Immun 31:1078-1085

상세보기
Sharma JM, Graham CK 1982 Influence of maternal antibody on efficacy of embryo vaccination with cell-associated and cell-free Marek's disease vaccine. Avian Dis 26:860-870

상세보기
Sharma JM 1983 Presence of adherent cytotoxic cells and non-adherent natural killer cells in progressive and regressive Marek's disease tumors. Vet Immunol Immunopathol 5:125-140

상세보기
Toth TE 2000 Nonspecific cellular defense of the avian respiratory system: a review. Dev Comp Immunol 24:121-139

상세보기
Van Zaane D, Brinkhof JM, Westenbrink F, Gielkens AL 1982 Molecular-biological characterization of Marek's disease virus. I. Identification of virus-specific polypeptides in infected cells. Virology 121:116-132

상세보기
Xing Z, Schat KA 2000a Inhibitory effects of nitric oxide and gamma interferon on in vitro and in vivo replication of Marek's disease virus. J Virol 74:3605-3612

상세보기
Xing Z, Schat KA 2000b Expression of cytokine genes in Marek's disease virus-infected chickens and chicken embryo fibroblast cultures. Immunology 100:70-76

상세보기

저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증