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NTIS 바로가기한국가금학회지 = Korean journal of poultry science, v.35 no.3, 2008년, pp.225 - 240
장형관 (전북대학교 수의과대학 전염병학.조류질병학연구실) , 박영명 (전북대학교 수의과대학 전염병학.조류질병학연구실) , 차세연 (전북대학교 수의과대학 전염병학.조류질병학연구실) , 박종범 (전북대학교 수의과대학 전염병학.조류질병학연구실)
Marek's disease virus(MDV) is a highly cell-associated, lymphotropic
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
마렉병 바이러스는 어떻게 전파되는가? | 1). MDV는 고도의 세포 의존성 바이러스이기 때문에 바이러스 감염 및 전파가 세포간 접촉을 통해 이루어지고, 바이러스 유전체도 감염세포가 세포분열을 통해 자매 세포를 형성하는 세포분열 과정을 통해 전파된다(Kaleta and Neumann, 1977). 바이러스는 여러 종류의 세포에 감염할 수 있지만 감염에 표적이 되는 주된 세포는 활성화 과정에 있거나 활성화된 림프구이다. | |
바이러스 감염에 주된 표적이 되는 세포는 무엇인가? | MDV는 고도의 세포 의존성 바이러스이기 때문에 바이러스 감염 및 전파가 세포간 접촉을 통해 이루어지고, 바이러스 유전체도 감염세포가 세포분열을 통해 자매 세포를 형성하는 세포분열 과정을 통해 전파된다(Kaleta and Neumann, 1977). 바이러스는 여러 종류의 세포에 감염할 수 있지만 감염에 표적이 되는 주된 세포는 활성화 과정에 있거나 활성화된 림프구이다. 따라서 MDV에 감염된 조류에서 일부의 림프구는 감염을 억제하는 방어 면역 형성에 관여하지만, 일부분은 바이러스 전파 과정에 표적 세포로 작용하여 병원성을 유발시키는 원인으로 작용하기도 한다. | |
림프구 감염에 의한 바이러스 독성으로 인해 일어날 수 있는 일은 무엇이 있는가? | 따라서 MDV에 감염된 조류에서 일부의 림프구는 감염을 억제하는 방어 면역 형성에 관여하지만, 일부분은 바이러스 전파 과정에 표적 세포로 작용하여 병원성을 유발시키는 원인으로 작용하기도 한다. 림프구 감염에 의한 바이러스 독성으로 인해 숙주의 면역 체계가 약화되면 이로 인해 종양 유발뿐만 아니라 다른 병원체 감염에 대한 감수성을 증가시키는 원인으로 작용하게 된다. 바이러스 감염에 대한 감수성은 면역의 성숙 정도에 차이 없이 모든 일령의 닭에서 나타나지만, 백신을 통한 방어 면역 형성이 임상 증상 유발로부터 감수성이 있는 숙주를 방어할 수 있는 효과적인 수단으로 활용되어 바이러스의 폭넓은 감수성에 의한 피해를 감소시키고 있다. |
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