[논문]Carrageenan으로 유발한 관절염 쥐에서의 우슬추출물 효과

김영옥; 이상원; 이승은

Carrageenan으로 유발한 관절염 쥐에서의 우슬추출물 효과
Effects of Achyrantes japonica on Carrageenan-Induced Arthritis Rat Model 원문보기

韓國藥用作物學會誌 = Korean journal of medicinal crop science, v.17 no.6, 2009년, pp.470 - 474

김영옥 (국립원예특작과학원 인삼특작부) , 이상원 (국립원예특작과학원 인삼특작부) , 이승은 (국립원예특작과학원 인삼특작부)

Abstract ▼ AI-Helper

Achyrantes japonica (AJ) has been used to treat edema and arthritis in the traditional Korean medicine. To elucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AJ, the carrageenan-induced paw edema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used as a control drug. Treatment with AJ (200mg/kg p.o.) significantly reduced paw edema, compared to the carrageenan - treated rats. In the plantar test, the thermal withdrawal latency in AJ - treated group was significantly increased than the carrageenan - treated group. The results indicate that AJ could have be the anti-inflammatory and anti-nociceptive properties.

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제안 방법

However, if the mortality was not observed then the same dose was repeated again to confirm the toxic effect. If mortality was not observed, the procedure was then repeated with higher doses such as 100, 300, 1000 and 2000 mg/kg.
In this study, anti-nociceptive effect against thermally induced nociceptive pain stimuli was evaluated. As shown in Fig.

데이터처리

All results were expressed as mean ± S.E. Data were analyzed using one-way ANOVA followed by Duncan t-test.

이론/모형

The oral toxicity studies were performed. SD (n = 10) of either sex selected by random sampling technique were employed in this study. The animals were fasted for 4 h with free access to water only.
Thermal hypersensitivity was tested according to the Hargreave’s procedure (Hargreaves et al., 1988) using the plantar test (Ugo Basile, Comerio, Italy).

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