[논문]안티푸라민-에스® 로션의 레올로지 특성 연구

국화윤; 송기원

doi:10.4333/kps.2009.39.3.185

[국내논문] 안티푸라민-에스® 로션의 레올로지 특성 연구
Rheological Properties of Antiphlamine-S® Lotion 원문보기

藥劑學會誌 = Journal of Korean pharmaceutical sciences, v.39 no.3, 2009년, pp.185 - 199

국화윤 (부산대학교 응용화학공학부 유기소재시스템공학과) , 송기원 (부산대학교 응용화학공학부 유기소재시스템공학과)

Abstract ▼ AI-Helper

Using a strain-controlled rheometer [Advanced Rheometric Expansion System (ARES)], the steady shear flow properties and the dynamic viscoelastic properties of $Antiphlamine-S^{(R)}$ lotion have been measured at $20^{\circ}C$ (storage temperature) and $37^{\circ}C$ (body temperature). In this article, the temperature dependence of the linear viscoelastic behavior was firstly reported from the experimental data obtained from a temperature-sweep test. The steady shear flow behavior was secondly reported and then the effect of shear rate on this behavior was discussed in detail. In addition, several inelastic-viscoplastic flow models including a yield stress parameter were employed to make a quantitative evaluation of the steady shear flow behavior, and then the applicability of these models was examined by calculating the various material parameters. The angular frequency dependence of the linear viscoelastic behavior was nextly explained and quantitatively predicted using a fractional derivative model. Finally, the strain amplitude dependence of the dynamic viscoelastic behavior was discussed in full to elucidate a nonlinear rheological behavior in large amplitude oscillatory shear flow fields. Main findings obtained from this study can be summarized as follows : (1) The linear viscoelastic behavior is almostly independent of temperature over a temperature range of $15{\sim}40^{circ}C$. (2) The steady shear viscosity is sharply decreased as an increase in shear rate, demonstrating a pronounced Non-Newtonian shear-thinning flow behavior. (3) The shear stress tends to approach a limiting constant value as a decrease in shear rate, exhibiting an existence of a yield stress. (4) The Herschel-Bulkley, Mizrahi-Berk and Heinz-Casson models are all applicable and have an equivalent validity to quantitatively describe the steady shear flow behavior of $Antiphlamine-S^{(R)}$ lotion whereas both the Bingham and Casson models do not give a good applicability. (5) In small amplitude oscillatory shear flow fields, the storage modulus is always greater than the loss modulus over an entire range of angular frequencies tested and both moduli show a slight dependence on angular frequency. This means that the linear viscoelastic behavior of $Antiphlamine-S^{(R)}$ lotion is dominated by an elastic nature rather than a viscous feature and that a gel-like structure is present in this system. (6) In large amplitude oscillatory shear flow fields, the storage modulus shows a nonlinear strain-thinning behavior at strain amplitude range larger than 10 % while the loss modulus exhibits a weak strain-overshoot behavior up to a strain amplitude of 50 % beyond which followed by a decrease in loss modulus with an increase in strain amplitude. (7) At sufficiently large strain amplitude range (${\gamma}_0$>100 %), the loss modulus is found to be greater than the storage modulus, indicating that a viscous property becomes superior to an elastic character in large shear deformations.

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질의응답

핵심어	질문	논문에서 추출한 답변
	반고형 제제의 역학적 특징은?	이들 중에서도 특히 의약품에 속하는 물질을 반고형 제제(semi-solid dosage forms)라고 하여 연고제, 크림류, 로션류, 겔류, 안연고제, 좌제 등을 들 수 있으며 그 대부분은 신체의 국소에 적용하거나 전신효과를 얻고자 하는 목적으로 널리 사용되고 있다. 이러한 반고형 제제의 역학적 특징은 낮은 온도와 작은 크기의 외력하에서는 탄성적 특성이 강한 고체적(solid-like) 성질을 나타내는 반면에 높은 온도와 큰 크기의 외력하에서는 점성적 특성이 강한 액체적(liquid-like) 성질을 나타내는 복잡한 레올로지 거동(rheological behavior)[또는 점탄성 거동(viscoelastic behavior)]을 보이고 있는 점에 있다.1,2)
	반고형 물질 중 의약품에 속하는 물질은?	의약품, 화장품, 식품산업을 비롯한 다양한 산업분야에서는 고체적 성질과 액체적 성질을 공유하고 있는 소위 반고형 물질(semi-solid materials)로 분류되는 물질이 광범위하게 취급되고 있다. 이들 중에서도 특히 의약품에 속하는 물질을 반고형 제제(semi-solid dosage forms)라고 하여 연고제, 크림류, 로션류, 겔류, 안연고제, 좌제 등을 들 수 있으며 그 대부분은 신체의 국소에 적용하거나 전신효과를 얻고자 하는 목적으로 널리 사용되고 있다. 이러한 반고형 제제의 역학적 특징은 낮은 온도와 작은 크기의 외력하에서는 탄성적 특성이 강한 고체적(solid-like) 성질을 나타내는 반면에 높은 온도와 큰 크기의 외력하에서는 점성적 특성이 강한 액체적(liquid-like) 성질을 나타내는 복잡한 레올로지 거동(rheological behavior)[또는 점탄성 거동(viscoelastic behavior)]을 보이고 있는 점에 있다.
	고분자 물질의 경우 일반적으로 시간에 따른 탄성적 거동의 변화는 어떻게 구분하나?	고분자 물질의 경우 일반적으로 시간에 따른 탄성적 거동의 변화는 유리상태영역(glassy state region), 전이영역(transition region), 고무상 평탄영역(rubbery plateau region) 및 유동영역(flow region)의 네 단계로 구분된다. 또한 이러한 시간에 따른 특성은 시간-온도 중첩원리(time-temperature superposition principle)에 의해서 온도에 따른 탄성율의 변화로 변환하여 취급될 수 있다.

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