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한약재 포제 가공의 현대적 연구 현황
A Literature Survey of the Modern Techniques Used for the Processing of Herbal Medicines 원문보기

藥劑學會誌 = Journal of Korean pharmaceutical sciences, v.39 no.4, 2009년, pp.275 - 297  

오주희 (경희대학교 약학대학) ,  신재석 (경희대학교 약학대학) ,  안은석 (경희대학교 약학대학) ,  이성준 (경희대학교 약학대학) ,  이종철 (경희대학교 약학대학) ,  임준홍 (경희대학교 약학대학) ,  홍시갑 (경희대학교 약학대학) ,  홍준기 (경희대학교 약학대학) ,  이영주 (경희대학교 동서약학연구소)

Abstract AI-Helper 아이콘AI-Helper

Herbal medicines have been used worldwide, particularly in the Far East countries, for thousands of years. Herbal medicines comprise complex mixtures of different phytochemical substances, and their nature may vary substantially depending on many factors related to the cultivation condition, area an...

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문제 정의

  • 다만 해외 논문에서 “polyporus sclerotium”의 표준화를 위한 marker compound에 대한 연구 보고를 확인하였다.
  • 따라서 본 연구에서는 현재까지 이루어진 한약 포제에 대한 학술 논문을 포괄적으로 취합 정리함으로써 한약 포제의 현대적 연구흐름을 파악하고 한약의 안전성 관리를 위한 기초자료를 마련하고자 하였다.
  • 복령: 절편을 만들기 위해 반복하여 찌는 과정에서 발생한 다당류 함량의 변화에 대한 논문을 찾을 수 있었다.329)
  • 본 연구에서는 약전수재 한약재 109 종과 여기에 포함되지 않은 것들 중 전통 문헌에서 포제품을 사용한다고 보고된 품목 42종을 추가하여 총 151종의 한약의 포제에 대하여 RISS, KISS, DBPIA 등의 국내 문헌 데이터베이스와 PubMed 및 ScienceDirect 등의 국외 학술 문헌 데이터베이스를 이용한 종합적 문헌검색을 통해 각 약재에 대한 전통적인 포제 방법에 따른 성분 변화나 약리 효과 등에 대한 과학적 보고 사례를 체계적으로 검토하였다. 특히 아직까지 중국어로 된 논문에 대한 접근성이 낮은 것에 주목하여 간 자체로 된 한문명과 포제 및 변화를 주제어로 하여 구글 검색엔진을 활용하여 검색 정리하였다.
  • 부자: 예상외로 많은 논문이 검색되지는 않았으나 aconitine, higenamine, coryneine 등의 성분변화를 통해 부작용을 줄이고 강심작용은 유지하여 부자의 효능을 효율적으로 적용하기 위한 연구를 찾을 수 있었다.63-66)
  • 산수유: 산사와 마찬가지로 주로 과핵을 제거하고 사용하는 것으로 알려져 있으며, 과핵에는 소량의 유효 성분만이 함유되어 있음을 밝히는 동시에 과핵을 효과적으로 제거하는 방법에 대하여 연구한 논문을 확인하였다.245) 더불어 포제품과 생품의 loganin, morroniside 및 유기산 등의 함량을 비교한 연구도 있었다.
  • 본 연구는 약전수재 한약재 109 종과 여기에 포함되지 않은 것들 중 전통 문헌에서 포제품을 사용한다고 보고된 품목 42종을 추가하여 총 151종의 한약을 대상으로 실시하였다(Table I). 우선 각 약재에 대한 전통적인 포제방법과 그에 따른 특징에 대하여 검토하고 포제에 대한 현대적 연구논문을 검색한 후 그 연구내용을 비교함으로써 전통적 포제방법과 현대적 포제 연구 사이의 관련성을 도출하고자 하였다.
  • 차전자: 포제가 차전자 중 plantenolic acid 함량에 미치는 영향에 대한 연구를 확인하였다.275)
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질의응답

핵심어 질문 논문에서 추출한 답변
인삼의 포제와 관련된 연구가 많은 이유는? 인삼: 본 연구의 대상 약재 중 가장 활발하게 연구되고 있었으며 포제와 관련된 연구도 다수 찾을 수 있었다. 이는 홍삼, 흑삼, 효삼, 선삼 등 다른 약재에 비하여 다양한 포제품이 있으며 최근 인삼 자체에 대한 수요보다 포제품, 특히 홍삼에 대한 수요가 증가하고 있는 상황을 반영한 결과라고 생각된다. 가공 과정 중의 성분 변화에 대한 연구가 많았는데 전통적인 방법을 비롯하여 현대에 와서 새롭게 개발된 생산 방법도 소개되어 있었으며,108-132) 건조 및 저장 과정에서 발생하는 변화에 대한 보고도 있었다.
한약의 약재는 포제 과정에 의해 어떤 변화가 있는가? 한약은 채취한 후 생품 혹은 단순 건조과정을 거쳐 약재로서 사용하기도 하지만 일반적으로 포제라고 하는 일종의 가공과정을 거친 후 약재로 이용되는데 이러한 포제 과정에 의해 동일한 약재의 효능의 강도가 변하기도 하고 본래와는 다른 작용을 나타내기도 한다는 사실이 경험적으로 잘 알려져 있으며, 전통문헌에 수록된 포제과정은 현대의 한약재의 가공에 있어서도 준수되고 있는 사항이다. 다만 포제과정에서 발생하는 물리화학적 변화에 대하여 과학적으로 입증된 바는 일부 사용 빈도가 높은 수 개의 약재를 제외하고 부족한 실정이며 특히 국내에서는 이에 대한 높은 관심에도 불구하고 아직 문헌적 자료가 부족한 실정이다.
계피의 전통적인 포제법은 무엇인가? 계피: 포제에 대한 연구는 국내에서 1건 찾을 수 있었는데, 외피와 내피의 cinnamic acid 함량을 비교하여 계피의 전통적인 포제법인 “거피(去皮)”의 현대적 의미에 대하여 검토하였으며 이와 함께 최적의 보관 및 전탕법에 대한 조건 설정도 수행하였다.302)
질의응답 정보가 도움이 되었나요?

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