[논문]Medetomidine과 Tramadol이 개에서 Isoflurane의 최소 폐포 농도에 미치는 영향

김경미; 정종태; 박현정

Medetomidine과 Tramadol이 개에서 Isoflurane의 최소 폐포 농도에 미치는 영향
Effects of Medetomidine and Tramadol Administration on the Minimum Alveolar Concentration of Isoflurane in Dogs 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.27 no.6 = no.77, 2010년, pp.668 - 673

김경미 (제주대학교 수의과대학.수의과학연구소) , 정종태 (제주대학교 수의과대학.수의과학연구소) , 박현정 (제주대학교 수의과대학.수의과학연구소)

초록
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본 연구는 tramadol과 medetomidine이 개에서 isoflurane의 최소폐포농도에 미치는 영향에 대해 알아보고자 하였다. Isoflurane의 최소폐포농도는 1 ml의 생리식염수(control), $2{\mu}g$/kg의 medetomidine (M2), 4 mg/kg의 tramadol (T4), $2{\mu}g$/kg medetomidine과 4 mg/kg tramadol (M2T4)의 투여 네 가지 경우에 따라 측정되었다. 실험 중 심박수, 혈압, 호흡수, 호기말 이산화탄소분압, 혈중산소포화도, 체온을 측정하였다. M2, T4, M2T4 투여 후 isoflurane의 최소 폐포농도는 각각 $0.81{\pm}0.17%$, $0.81{\pm}0.14%$, $0.62{\pm}0.13%$로 대조군$1.13{\pm}0.19%$ 에 비해서 낮았다. 심박수는 M2, T4, M2T4 투여 시 낮았고 혈압은 M2T4투여 시에만 유의적으로 높았다. Tramadol 과 medetomidine의 투여 및 두 약물의 혼합투여는 isoflurane의 최소폐포농도를 유의적으로 낮추었다. 특히 tramadol과 medetomidine의 혼합투여는 마취제의 절감효과와 심혈관계에 있어 변화가 적기 때문에 전마취제로서 유용하게 사용될 수 있을 것이다.

Abstract ▼ AI-Helper

This study was to evaluate the effects of tramadol and medetomidine administration on minimum alveolar concentration (MAC) of isoflurane in dogs. MAC of isoflurane was determined in four occasions; 1 ml saline (Control), $2{\mu}g$/kg medetomidine (M2), 4 mg/kg tramadol (T4), $2{\mu}g$/kg medetomidine-4 mg/kg tramadol combination (M2T4). Heart rate, blood pressure, respiratory rate, end-tidal carbon dioxide concentration, saturation of hemoglobin with oxygen and body temperature were recorded. After administration of M2 ($0.81{\times}0.18%$), T4 ($0.81{\times}0.14%$) and M2T4 ($0.62{\times}0.12%$), less isoflurane was required than the control value ($1.13{\times}0.19%$). Significantly lower heart rate than the control value was detected after treatment of M2, T4, and M2T4. When only M2T4 was administered, blood pressure was significantly higher than the control value. In conclusion, administrations of tramadol, medetomidine and medetomidine-tramadol combination decreased the MAC of isoflurane in dogs. Especially, medetomidine-tramadol combinations could be useful as a premedication because of the anesthetic sparing effect and moderate changes in cardiovascular system.

주제어

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문제 정의

The purpose of this study was to evaluate the effects of medetomidine, tramadol and their combination on the MAC of isoflurane, cardiovascular and respiratory system in dogs.

제안 방법

The variation of MACs is the result of inconsistency in stimulus methods, anatomical sites, the subjectivity of researchers and individual differences (31). In order to minimize variation during this experiment, we restricted the observer to one person throughout the research period and stimuli were applied to the same anatomical site using one instrument.
5% end-tidal isoflurane for at least 20 minutes. The modified tail clamp method was used to measure MAC of the isoflurane (7,16,25). The two single stimulus, clamping the tail with a Backhaus towel clamp for 20 seconds, were delivered in 10 second intervals.

대상 데이터

Eight mixed-breed dogs aged 1~3 years were used in this study. The mean standard body weight was 10.

데이터처리

MAC value and cardio respiratory data were analyzed using ANOVA for repeated measures followed by a Tukey post test. The percentage change in MAC was calculated as [(MACtreatment− MACcontrol)/MACcontrol] × 100.

성능/효과

In conclusion, administrations of medetomidine, tramadol and medetomidine-tramadol combinations decrease the requirement of isoflurane in dogs. Even though effects of medetomidine-tramadol combinations on heart rate and blood pressure are statistically significant, medetomidine-tramadol combinations could be useful as a premedication because of the anesthetic sparing effect and moderate changes in cardiovascular system.
But in other study, it was not evident that an additional reduction in MAC when tramadol was administered with butorphanol and hydromorphone in cats (11). The results of this study indicate that medetomidine enhanced the inhalant sparing effect without an alteration in effect of tramadol. Inhalant sparing effect of M2T4 was proved as 44.

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