14년령의 잡종 암컷 고양이가 다식증, 과잉행동 및 체중감소를 주증으로 내원 하였다. 신체검사에서 빈맥과 고혈압이 확인되었으며, 실험실 검사를 통하여 요소 질소 증 및 갑상선 호르몬 (TT4, fT4)의 상승이 확인 되었다. 환자는 확진을 위하여 T3 억압 시험이 시행 되었으며, 검사 결과 외부에서 T3가 공급된 전후의 갑상선 호르몬 수치에 변화가 없는 것이 확인 되었다. 따라서, 환축은 만성 신부전에 병발한 갑상선 기능 항진증으로 진단되었으며, 메티마졸을 이용한 약물 관리가 실시 되었다. 결론적으로 본 증례의 경우 고양이에서 발생한 만성 신부전에 병발한 갑상선 기능 항진증의 임상증상과 진단, 그리고 치료 반응에 대한 국내 첫 증례보고이다.
14년령의 잡종 암컷 고양이가 다식증, 과잉행동 및 체중감소를 주증으로 내원 하였다. 신체검사에서 빈맥과 고혈압이 확인되었으며, 실험실 검사를 통하여 요소 질소 증 및 갑상선 호르몬 (TT4, fT4)의 상승이 확인 되었다. 환자는 확진을 위하여 T3 억압 시험이 시행 되었으며, 검사 결과 외부에서 T3가 공급된 전후의 갑상선 호르몬 수치에 변화가 없는 것이 확인 되었다. 따라서, 환축은 만성 신부전에 병발한 갑상선 기능 항진증으로 진단되었으며, 메티마졸을 이용한 약물 관리가 실시 되었다. 결론적으로 본 증례의 경우 고양이에서 발생한 만성 신부전에 병발한 갑상선 기능 항진증의 임상증상과 진단, 그리고 치료 반응에 대한 국내 첫 증례보고이다.
A 14-year-old spayed, mixed breed, female cat was admitted for evaluation of a polyphagia, hyperactivity and chronic weight loss. Physical examination revealed a tachycardia and mild elevated systemic blood pressure. This cat had azotemia and mild increased total thyroxin (TT4) and free thyroxin con...
A 14-year-old spayed, mixed breed, female cat was admitted for evaluation of a polyphagia, hyperactivity and chronic weight loss. Physical examination revealed a tachycardia and mild elevated systemic blood pressure. This cat had azotemia and mild increased total thyroxin (TT4) and free thyroxin concentration. However triiodothyronine (T3) level was normal, the T3 suppression test for definite diagnosis were made. No changes of TT4 serum concentration before and after the exogenous T3 administration in this cat showed hyperthyroidism. This cat was diagnosed as mild hyperthyroidism concurrent with chronic kidney disease (CKD) and antithyroid drug, methimazole, was used for medical management. This is first case report describing clinical and laboratory characteristic features of feline hyperthyroidism complicated with CKD and its clinical outcome using medical management in our country.
A 14-year-old spayed, mixed breed, female cat was admitted for evaluation of a polyphagia, hyperactivity and chronic weight loss. Physical examination revealed a tachycardia and mild elevated systemic blood pressure. This cat had azotemia and mild increased total thyroxin (TT4) and free thyroxin concentration. However triiodothyronine (T3) level was normal, the T3 suppression test for definite diagnosis were made. No changes of TT4 serum concentration before and after the exogenous T3 administration in this cat showed hyperthyroidism. This cat was diagnosed as mild hyperthyroidism concurrent with chronic kidney disease (CKD) and antithyroid drug, methimazole, was used for medical management. This is first case report describing clinical and laboratory characteristic features of feline hyperthyroidism complicated with CKD and its clinical outcome using medical management in our country.
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제안 방법
Exogenous T3 (liothyronine; Dalim biotech, Seoul, Korea) was administerd (25 µg/cat, PO, q 8 h) for 2 days (6 doses) and on the morning of the 3rd day, final dose of T3 was administered.
The cat was initially diagnosed as chronic kidney disease (CKD), stage 2. To rule out hyperthyroidism and cardiac disease, further tests, such as thyroid hormone profiles and echocardiography were evaluated. Echocardiography identified no ventricular thickening.
성능/효과
A 14-year-old spayed, mixed breed, female cat was admitted for evaluation of a chronic weight loss, hyperactivity and intermittent vomiting over last six-month period. Physical examination revealed a tachycardia (over 240 beats per minute), poor body condition, excessive shed and poor hair coat.
After administration of exogenous T3, serum TT4 concentrations were not changed in this cat, which usually significantly decreased in normal thyroid functional cat. The final diagnosis of this cat was mild hyperthyroidism concurrent with CKD.
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