We studied a comparison of the concentration of biochemical markers in sera of patients hospitalized with high fever (n=296) in Jeonbuk province during the last 2 years (2008 to 2009). The patients were divided into three patient groups of viral hemorrhagic fever (VHF) patient group tested positive ...
We studied a comparison of the concentration of biochemical markers in sera of patients hospitalized with high fever (n=296) in Jeonbuk province during the last 2 years (2008 to 2009). The patients were divided into three patient groups of viral hemorrhagic fever (VHF) patient group tested positive for Hantavirus (n=53), leptospirosis (LEP) patient group tested positive for Leptospira interrogans (n=137) and scrub typhus (TSU) patient group tested positive for Orientia tsutsugamushi (n=106). We analyzed the concentration of ALP, AST, ALT, blood urea nitrogen, creatinine and glucose and compared the mean levels of them to normal range, the first sample and last sample. The frequencies of abnormal patient elevated above the upper limit of normal for ALP, AST and ALT were 18~43.4%, 78~97% and 62.3~92.7% in patient groups, and 24.5~47.4% (total protein) and 13.2~50.0% (albumin) of patients in patient groups had decreased below the lower limit of normal. The patients showed higher abnormal levels of glucose in patient groups were 58.5% (viral hemorrhagic fever patient group), 66.4% (leptospirosis patient group), 71.7% (scrub typhus patient group) and 66.9% (total patient group). There were significant difference between the first sample and the last sample in the mean levels of AST (decreased 22.2% in viral hemorrhagic fever patient group, 30.2% in leptospirosis patient group, 20.4% in scrub typhus patient group and 24.1% in total patient group), BUN (43.0% in viral hemorrhagic fever patient group, 41.6% in leptospirosis patient group, 47.4% in scrub typhus patient group and 43.0% in total patient group) and glucose (20.2% viral hemorrhagic fever patient group, 17.9% in leptospirosis patient group, 18.6% in scrub typhus patient group and 18.9% in total patient group) in the first sample and the last sample. According to these results, those diseases may cause liver damage and have high concentration of ALP, AST, ALT and glucose in blood even though the patients get out of the hospital.
We studied a comparison of the concentration of biochemical markers in sera of patients hospitalized with high fever (n=296) in Jeonbuk province during the last 2 years (2008 to 2009). The patients were divided into three patient groups of viral hemorrhagic fever (VHF) patient group tested positive for Hantavirus (n=53), leptospirosis (LEP) patient group tested positive for Leptospira interrogans (n=137) and scrub typhus (TSU) patient group tested positive for Orientia tsutsugamushi (n=106). We analyzed the concentration of ALP, AST, ALT, blood urea nitrogen, creatinine and glucose and compared the mean levels of them to normal range, the first sample and last sample. The frequencies of abnormal patient elevated above the upper limit of normal for ALP, AST and ALT were 18~43.4%, 78~97% and 62.3~92.7% in patient groups, and 24.5~47.4% (total protein) and 13.2~50.0% (albumin) of patients in patient groups had decreased below the lower limit of normal. The patients showed higher abnormal levels of glucose in patient groups were 58.5% (viral hemorrhagic fever patient group), 66.4% (leptospirosis patient group), 71.7% (scrub typhus patient group) and 66.9% (total patient group). There were significant difference between the first sample and the last sample in the mean levels of AST (decreased 22.2% in viral hemorrhagic fever patient group, 30.2% in leptospirosis patient group, 20.4% in scrub typhus patient group and 24.1% in total patient group), BUN (43.0% in viral hemorrhagic fever patient group, 41.6% in leptospirosis patient group, 47.4% in scrub typhus patient group and 43.0% in total patient group) and glucose (20.2% viral hemorrhagic fever patient group, 17.9% in leptospirosis patient group, 18.6% in scrub typhus patient group and 18.9% in total patient group) in the first sample and the last sample. According to these results, those diseases may cause liver damage and have high concentration of ALP, AST, ALT and glucose in blood even though the patients get out of the hospital.
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제안 방법
It is necessary to determine the predictors that identify markers of severe febrile disease in order to reduce the mortality due to the high incidence of severe manifestations or complications and the delay in treatment. In this study, to identify biochemical markers in laboratory findings, we measured the concentration of the markers in serum of patients who were hospitalized from the VHF, lq)tospirosis and scrub typhus.
2 years (2(X)8 to 2009). The patients were divided into three patient groups of VHF patient group tested positie for Hantavirus (n-53), LEP patient gmup tested positive for Leptospira interrogans (n= 137) and TSU patient grip tested positive for Orientia tsWsugenushi (n=106) by serological immunoassay method as described previously (Griner et al., 1981; Linderholm and Elgh, 2001; Chappel et al., 2004). We collected blood two times from each fasting hospitalized patient.
The average concentration of biochemical marker in the first samples in each patient group were compared with those in the last samples, and then we calculated the relative decrease rate (%) of the average concentration of ALP, AST, ALT, total protein, albumin, blood urea nitogen, creatinine and glucose in the last sample groups to tiiose in the first sample groups (Fig. 2). The average concentration of total protein, albumin, blood urea nitrogen, creatinine and glucose ine last samples of patients with viral hemorrhagic fever were significantly lower than those in ttie first samples of patients by 4.
Also, we can suggest that it is possible to have high concentration of tiiose chemicals in blood of patients before the development of those diseases in patient. In conclusion, our study was performed to investigate the variation of concentation of biochemical markers in blocxi of patients with vial hemorrhagic fever, leptospirosis and scrub typhus. We analyzed the concentration of ALP, AST, ALT, blood urea nitrogen, creatinine and glucose and compared the mean level잤 of them to normal range, the first sample and last sample.
In conclusion, our study was performed to investigate the variation of concentation of biochemical markers in blocxi of patients with vial hemorrhagic fever, leptospirosis and scrub typhus. We analyzed the concentration of ALP, AST, ALT, blood urea nitrogen, creatinine and glucose and compared the mean level잤 of them to normal range, the first sample and last sample. Our data suggest that viral hemorrfiagic fever (VHF), leptospirosis and scrub typhus disease may cause Iger damage and that many of patients have high concentration of ALR AST, ALT and glucose in blood even though e patients don't have any symptoms of iltaess when they get out of the hospital.
성능/효과
2). The average concentration of total protein, albumin, blood urea nitrogen, creatinine and glucose ine last samples of patients with viral hemorrhagic fever were significantly lower than those in ttie first samples of patients by 4.5% (P<0.003), 7.9% (P< 0.001), 41.6% (P<0.001), 12.5% (P<0.007) and 20.2% (P< 0.003), respectively. In the patient group with leptospirosis, the average concentrations of AST, BUN and glucose in the second samples of patients were significantly decreased by 30.
003), respectively. The average concentrations of BUN, creatinine and glucose in sera of patients with scrub typhus were significantly decreased by 47.4% (P<0.(M)l), 22.2% (P<0.001) and 18.6% (P<0.001)5 respectively In total patient group, AST, BUN, creatinine and glucose were significantly decreased by 24.1% (P<0.00I), 43.0% (P< 0.001), 15.9%(P<0.(X)l) mid 18.9%(P<0.001), respectively.
7~L3 m잉/dL), BUN (6-20 mg/dL) and glucose (74~106 mg/dL). The frequencies of abnormal patient elevated above the upper limit of normal for ALP, AST and ALT were 18-43.4%, 78~97% and 62, 3~92.7% in patient groups, and 24.5-47.4% (total protein) and 13.2 ~50.0% (albumin) of patiente in patient groups decreased below the lower limit of normal. These data suggest that viral hemorrhagic fever (VHF), leptospirosis 효nd scrub typhus disease may cause liver damae.
? 2002). In this study, the patients showed abnormal high glucose levels in patient groups were 58.5% (viral hemorrhagic fever patient group), 66.4% (leptospirosis patient group), 71.7% (scrub typhus patient group) and 66.9% (total patient group). These data suggest that the mechanism of inflammation of these diseases may be involved in the concentration of glucose in blood.
These data suggest that the mechanism of inflammation of these diseases may be involved in the concentration of glucose in blood. In our studies, there were significant difference between the first sample and the last sample in the mean levels of AST (decreased 22.2% in virai hemorrhagic fever patient group, 30.2% in leptospirosis patient grop, 20.4% in scrub typhus patient group and 24.1% in tot히 patient group), BUN (43.0% in viral hemonhagic fever patient group, 41.6% in leptospirosis patient group, 47.4% in scrub typhus patient gro and 43.0% in total patient group) and glucose (20.2% viral hemorrhagic fever patient group, 17.9% in leptospirosis patient group, 18.6% in scrub typhus patient group and 18.9% in total patient group) in the first sample and the last sample. But our data show that the concentration of ALP, AST, ALT and glucose are not reduced to normal levels of those concentrations.
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