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NTIS 바로가기Development & reproduction = 발생과 생식, v.14 no.4, 2010년, pp.297 - 306
송연화 (서울여자대학교 자연과학대학 생명환경공학과) , 정지은 (서울여자대학교 자연과학대학 생명환경공학과) , 이현아 (서울여자대학교 자연과학대학 생명환경공학과) , 홍지희 (서울여자대학교 자연과학대학 생명환경공학과) , 양현원 (서울여자대학교 자연과학대학 생명환경공학과)
Tributyltin (TBT), an endocrine disrupting chemical, has been reported to decrease testicular function by causing apoptosis in the testis, but this mechanism is not fully understood. Thus, in this study we examined whether TBT induces adipogenesis of the Leydig cells to find out the correlation betw...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
내분비 교란물질이란? | 내분비 교란물질이란 체내 항상성 유지를 담당하는 호르몬의 생산 혹은 작용을 교란하는 체외 물질로 대부분의 환경오염 물질들이 여기에 포함된다. 현재까지 알려진 환경성 내분비교란물질만도 100종이 넘고 있으며, 대표적으로 Dioxin, Polychlorinated biphenyl(PCB), bisphenol A, Dichlorodiphenyltrichloroethane(DDT) 및 Tributyltin(TBT) 화합물 등이 알려져 있다. | |
TBT 화합물의 수중 생태계에 어떤 악영향을 미치는가? | 유기그룹이 하나 혹은 둘일 때보다 세 개일 때 독성이 크며, 그 중에서도 TBT가 가장 독성이 강한 것으로 알려져 있다(Craig, 1986). 이러한 TBT 화합물은 해양오염의 주범으로 복족류, 연체동물, 어류 등 수중 생물의 생식기관 발달에 이상을 초래하면서 수중 생태계에 심각한 문제를 일으키는 것으로 보고하고 있다(Blaber, 1970; Gibbs & Bryan, 1986). 또한 TBT가 포유류에 노출될 경우 어패류에서와 마찬가지로 생식기능에 문제를 야기시킬 수 있으며, 더욱이 간, 신경 및 면역 기관 등에 심한 독성을 나타내는 것으로 보고하고 있다(Ogata et al. | |
신생아시기에 TBT에 노출되면 TBT와 PPARγ와의 상호작용으로 인해 태아와 세포에 어떤 영향을 주나요? | , 2009). 또한 태아 또는 신생아시기 때 TBT에 노출되면 세포 내 PPARγ가 활성화되면서 지방세포로의 분화가 촉진되고, 아울러 세포 내 지질이 축적되면서 비만이 유도되는 것으로 보고하고 있다(Kirchner et al., 2010). |
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