[논문]세균성 요로 감염증 애완견의 세균 분포 및 항생제 감수성

최대영; 최대성; 장형관; 송희종; 조정곤

세균성 요로 감염증 애완견의 세균 분포 및 항생제 감수성
Antimicrobial Susceptibility of Bacterial Isolates from Domestic Dogs with Urinary Tract Infection 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.27 no.1 = no.72, 2010년, pp.6 - 10

최대영 (전북대학교 수의과대학.인수공통전염병연구소) , 최대성 (전북대학교 수의과대학.인수공통전염병연구소) , 장형관 (전북대학교 수의과대학.인수공통전염병연구소) , 송희종 (전북대학교 수의과대학.인수공통전염병연구소) , 조정곤 (전북대학교 수의과대학.인수공통전염병연구소)

초록
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2003년부터 2009년까지 서울 지역 동물병원에 의뢰된 세균성 요로 감염증 개의 병소에서 세균의 분리빈도와 항생제 감수성을 조사한 결과는 다음과 같다. 세균성 요로 감염증 개의 뇨에서 Escherchia coli 27주, Streptoococcus spp. 7주, Staphylococcus spp. 5주, Enterobacter spp. 3주, Proteus spp. 2주, 그리고 기타 세균 3주, 총 47주의 세균이 분리되었다. 이 중 분리 빈도가 높은 E. coli, Streptoococcus spp. 및 Staphylococcus spp.를 대상으로 항생제 감수성을 조사하였다. E. coli의 항생제 감수성은 imimpenem, polymyxin B, amikacin, cephalosporins, aztreonam, amoxicillin clavulate, cephalosporins, tricarcillin, amoxicillin clavulate 순으로 나타난 반면 bacitracin, erythromycin, lincomycin, oxacillin, penicillin, novobiocin 등에 대해서는 높은 내성을 나타내었다. Streptoococcus spp.의 항생제 감수성은 bacitracin, imimpenem, trimethoprime-sulfa 순이었고 amikacin, cefotaxim, cefoxitin, cloxacillin, gentamicin, lincomycin, oxacillin, penicillin, streptomycin, tobramycin에는 매우 높은 내성을 나타내었다. Staphylococcus spp.의 항생제 감수성은 cefoxitin, doxycycline, enrofloxacin, imimpenem, tobramycin에 매우 높았고 aztreonam, tetracycline에 내성을 나타내었다.

Abstract ▼ AI-Helper

Bacterial pathogens were isolated from dogs with urinary tract infection (UTI) in local animal hospitals between August 2003 and December 2009. Bacteria were isolated from urine of 47 dogs. The isolated pathogens were Escherichia coli (n = 27), Streptococcus spp. (n = 7), Staphylococcus spp. (n = 5), Enterobacter spp. (n = 3), Proteus spp. (n = 2), other species were 3 strains, respectively. E. coli were susceptible to imimpenem, polymyxin B, amikacin, cephalosporins, aztreonam, amoxicillin clavulate, cephalosporins, tricarcillin, and amoxicillin clavulate, while were resistant bacitracin, erythromycin, lincomycin, oxacillin, penicillin, and novobiocin. Streptococcus spp. were susceptible to bacitracin, imimpenem, and trimethoprime-sulfa, while were highly resistant amikacin, cefotaxim, cefoxitin, cloxacillin, gentamicin, lincomycin, oxacillin, penicillin, streptomycin, and tobramycin. Staphylococcus spp. were susceptible to cefoxitin, doxycycline, enrofloxacin, imimpenem, and tobramycin, but were resistant aztreonam and tetracycline.

주제어

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문제 정의

This study emphasizes the need for bacterial culture, species identification, and susceptibility testing in order to choose appropriate antimicrobial agents and to improve the clinical therapeutic approach for canine UTIs.

제안 방법

The objectives of this study were to estimate the prevalence of uropathogens in dogs with urinary tract infections, to apply the formula to help select rational antimicrobial therapy, and to identify changes in antimicrobial resistance among canine uropathogens.

이론/모형

Antimicrobial susceptibility was assessed by the Kirby-Bauer disk diffusion method on Muellet-Hinton agar with commercial antibiotic discs (BBL), according to the standards of the Clinical Laboratory Standards Institute (CLSI). The disks of antibiotics used were listed in Table 1.

성능/효과

(n=5) from urine were higher susceptible to antibiotics than two major pathogens of UTI, described above. Antibiotics had the highest susceptibility were FOX, DC, ENR, IPM, and NN (100.0%, respectively), followed by AN, BC, CTX, CIP, CX, OX, PB, and RA (80.0%, respectively). The highest resistance was shown to ATM and TE (100.
For treatment of UTI, generally considered antibiotics were any of the penicillins and cephalosporins, teteracycline, fluoroquinolones, aminoglycosides, and trimethoprim-sulfonamides (4). In this study, the most effective antibiotics to E. coli isolated from urine were IPM followed by PB, and AN. Cepha-losporins, ATM, and AmC were more effective than aminoglycosides, macrolides, penicillin, quinolones, and sulfonamides.
4%). The highest rates of resistance were shown to AN, ATM, CTX, FOX, CX, GM, LM, OX, PIP, SM, and NN (100.0%, respectively), CL, PB, and TE (85.7%, respectively). Staphylococcus spp.
The results of antimicrobial susceptibility of E. coli (n = 27) from urine showed that the highest rates were IPM (100.0%), followed by PB (70.4%), and AN (63.0%). Other drugs were susceptible less than 60.
This study shows a number of organisms isolated from clinical specimens had multiple drug resistance (MDR; 97% of all isolates). One study reported, in UK, percentage MDR in various bacterial pathogens isolated from clinical cases at small animal referral hospital (24).

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