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NTIS 바로가기Journal of plant biotechnology = 식물생명공학회지, v.37 no.1, 2010년, pp.57 - 66
Programmed cell death systems are important for an active type of cell deaths. Among them, a type of programmed cell death, autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Thus, in the area of cance...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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Autophagy는 어떤 것이며, 어떤 것과 차별화되나요? | Autophagy는 programmed cell death의 하나의 작용 메커니즘으로 apoptosis와 유사하지만 apoptosis와는 세포의 형태 및 작용기전 면에서 차별화되고 있다. 특히, autophagy의 작용기전으로 Mtor pathway, p53에 의한 조절, class III PI3K 등의 경로를 통하여 조절되고 있으며, 여기에 관여하는 inhibitor로서의 oncogene 및 activator로서의 oncosuppressor들이 다양하게 밝혀지고 있다. | |
천연물의약품은 무엇인가요? | 천연물의약품은 식물, 동물, 미생물 및 세포내용물과 광물 등 자연계에 존재하는 물질을 의약품으로 사용하는 것을 말하며, 광범위하게 정의되는 첨단 바이오기술을 포함하는 바이오의약품의 일부로 정의될 수 있다. 이러한 천연물 중 특히 식물에는 다양한 성분들이 서로 상호 작용하면서 혼합되어 있는 형태로 다양한 질환에 대한 조합치료 (combination therapy)에 이용될 수 있으며, 생체 내에서 다중 타겟에 영향을 미치므로 천연물에 함유되어 있는 다양한 성분이 함유되어 있는 조추출물 (crude extract), 용매분획물 (solvent fraction)을 의약품으로 이용하거나, 이로부터 분리된 단일성분 화합물 또는 이에 대한 유도체를 합성하여 새로운 의약품에 대한 개발이 시도되고 있다. | |
세포의 malignant transformation과의 연관성에 대한 연구로 정상 세포에 비해 암세포에서는 어떤 변화가 있나요? | 1970년대에서 1980년대까지 autophagy 활성과 세포의 malignant transformation과의 연관성에 대한 연구가 진행되었다. 특히 정상세포에 비하여 암세포에서는 autophagy의 활성이 매우 약하게 발현되고 있는 것으로 보고되고 있으며, 암세포의 성장환경 중 세포가 매우 밀집되거나 serum 및 아미노산이 결핍되었을 경우 autophagy의 활성이 증가되어 세포사를 유도할 수 있을 것으로 보고된 바있다. 즉 transformed cell의 경우 nutrient 및 serum의 결핍 상태에서 autophagy가 활성화되어 protein이 degradation되어 세포사가 나타나는 것으로 많은 연구자에 의하여 관찰되었다 (Gunn et al. |
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