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NTIS 바로가기대한생식의학회지= The Korean journal of reproductive medicine, v.37 no.1, 2010년, pp.1 - 12
김선영 (연세대학교 의과대학 산부인과학교실 강남세브란스 병원) , 이병석 (연세대학교 의과대학 산부인과학교실 강남세브란스 병원)
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핵심어 | 질문 | 논문에서 추출한 답변 |
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CA-125란 무엇인가? | 우리가 흔히 알고 있는 CA-125는 진행된 자궁내막증에서 진단 및 치료 후 재발의 주된 표지자(marker)로서 임상적 유용성이 우수한 편이나 초기 자궁내막증 진단에 있어 민감도, 특이도가 낮아 이를 대체할 수 있는 여러 가지 혈청, 복막액 및 각종 조직 표지자에 대한 연구들이 진행되었다. 초기 자궁내막증에 있어 체액 표지자를 찾아내기 위해 혈청, 복막액 (peritoneal fluid, PF), 분비 단백질 (secretory proteins), 세포간 결합분자 (cell adhesion molecules), 사이토카인 (cytokines), 종양 괴사인자 (tumor necrosis factor), 혈관내피성장인자 (vascular endothelial growth factor), 케모카인(chemokine), 항내막항체 (antiendometrial antibody), 아로마테이스 P450 발현 (aromatase P450 expression) 호르몬 수용체 등에 대한 연구가 포함되었으며 이러한 연구내용을 바탕으로 본 저자는 자궁내막증의 진단에 있어 비수술적 방법을 통한 여러 물질들의 진단적 정확성 및 임상적 유용성을 소개 및 비교하고자 한다. | |
사람의 조직에서 OPN은 어디에서 생산되는가? | Osteopontin (OPN)은 70-kDa secreted phosphorylated glycoprotein으로 뼈기질 (bone matrix)에서 기원된다.76 사람의 조직에서 osteopontin은 소화기계, 비뇨생식계, 담낭, 이자, 수유중인 유방, 침샘 등에서 생산되는 것으로 알려져 있다. 또한 Osteopontin은 활성화된 대식세포, 림프구 그리고 활성화된 T-림프구 등에 의해 분비되며 염증 반응의 장소로 알려진 세포외액과 미네랄화된 세포외 기질 (extracellular matrix)에도 존재한다. | |
자궁내막증이란 무엇인가? | 만성 골반통증이나 불임을 유발하는 가장 흔한 부인과적 질환 중 하나인 자궁내막증은 자궁내막 조직이 정상 자궁 위치를 벗어나 자궁강 밖에 존재 하는 질환으로 정의할 수 있다. 자궁내막증은 흔히 난소나 골반 복막에서 발견되나 장, 방광, 요관은 물론이고 골반 밖 장기인 폐에서도 진단되며 전형 적으로 복강경을 통한 수술적 방법으로 확진을 하게 되나 증상이 없는 사람에서도 자궁내막증이 있을 수 있다. |
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