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Inhibitory Effects of YP 12, A Newly Synthesized Obovatol Derivative on Rat Aortic Vascular Smooth Muscle Cell Proliferation 원문보기

한국식품위생안전성학회지 = Journal of food hygiene and safety, v.26 no.3, 2011년, pp.187 - 191  

Lim, Yong (Department of Clinical Laboratory Science, Dong-eui Univerisity) ,  Lee, Mi-Yea (Department of Social Welfare, World Cyber College) ,  Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University) ,  Pyo, Myoung-Yun (College of Pharmacy, Sookmyung Women's University) ,  Yun, Yeo-Pyo (College of Pharmacy, Chungbuk National University)

Abstract ▼ AI-Helper 아이콘AI-Helper

Platelet derived growth factor (PDGF)-BB is one of the most potent vascular smooth muscle cell(VSMC) proliferative factors, and abnormal VSMC proliferation by PDGF-BB plays an important role in the development and progression of atherosclerosis. The aim of this study was to assess the effect of YP 1...

주제어

#Atherosclerosis   #proliferation   #vascular smooth muscle cell   #PDGF-BB  

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  • Cells were then washed twice with icecold PBS and incubated with RNase and propidium iodide (PI), a DNA-intercalating dye. Cell cycle phase analysis was performed using the FACSCalibur (Becton-Dickinson Co., San Jose, USA) and the proportion of cells within the G0/G1, S and G2/M phases was determined by analysis with ModFit LT V2.0 (Verity Software House, Topsham, USA).
  • PDGF is one of the most potent mitogenic and chemotactic agents for VSMCs released by platelets, endothelial cells and VSMCs themselves, and is a major component of fetal bovine serum (Stroobant & Waterfield, 1984). The purposes of the present study were to find out whether YP 12, a newly synthesized obovatol derivate (Fig. 1), possesses an anti-proliferative effect on PDGF-BB-stimulated rat aortic VSMCs. In the present study, we demonstrated that YP 12 potently inhibited rat aortic VSMC proliferation (Fig.

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  • The experimental results were expressed as mean± S.E.M. A one-way analysis of variance (ANOVA) was used for multiple comparison followed by Dunnett. Differences with P < 0.
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참고문헌 (19)

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  7. Fang, F., & Newport, J. W. (1991). Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell, 66(4), 731-742. 

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    원문보기 상세보기

  10. Lee, S. K., Kim, H. N., Kang, Y. R., Lee, C. W., Kim, H. M., Han, D. C., et al. (2008). Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis. Bioorg Med Chem, 16(18), 8397-8402. 

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  11. Lim, Y., Kwon, J. S., Kim, D. W., Lee, S. H., Park, R. K., Lee, J. J., et al. (2010). Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1. Atherosclerosis, 210(2), 372-380. 

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  12. Majesky, M. W., Reidy, M. A., Bowen-Pope, D. F., Hart, C. E., Wilcox, J. N., & Schwartz, S. M. (1990). PDGF ligand and receptor gene expression during repair of arterial injury. J Cell Biol, 111(5 Pt 1), 2149-2158. 

  13. Mulvany, M. J. (1990). Structure and function of small arteries in hypertension. J Hypertens Suppl, 8(7), S225-232. 

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  17. Ross, R. (1999). Atherosclerosis--an inflammatory disease. N Engl J Med, 340(2), 115-126. 

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  18. Sachinidis, A., Locher, R., Vetter, W., Tatje, D., & Hoppe, J. (1990). Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells. J Biol Chem, 265(18), 10238-10243. 

  19. Stroobant, P., & Waterfield, M. D. (1984). Purification and properties of porcine platelet-derived growth factor. EMBO J, 3(12), 2963-2967. 

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